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The importance of mitochondrial dysfunction was separately determined as a significant factor in increasing the risk of developing Alzheimer\u2019s disease (AD) in patients after traumatic brain injury (TBI). In TBI, there is a decrease in the expression of tight junction (TC) proteins of endothelial cells, such as occludin, claudin, JP, which leads to increased permeability of the blood-brain barrier. TBI, provoking endothelial dysfunction, contributes to the development of metabolic disorders of \u03b2-amyloid and tau protein, which in turn leads to worsening vascular damage, resulting in a vicious circle that can ultimately lead to the development of AD and dementia. Age-related changes in cerebral arteries, which impair perivascular transport of interstitial fluid, are currently considered as an important part of the \u00abamyloid cascade\u00bb, especially against the background of genetically mediated disorders of glial membranes associated with defective aquaporin-4 (encoded by the APOE4). Studies in animal models of TBI have revealed an increase in tau protein immunoreactivity and its phosphorylation, which correlates with the severity of injury. A comprehensive analysis of research results shows that the cascade of reactions triggered by TBI includes all the main elements of the pathogenesis of AD: disorders of energy metabolism, microcirculation and clearance of cerebral metabolic products. This leads to a disruption in the metabolism of amyloid protein and its accumulation in brain tissue with the subsequent development of tauopathy. Cerebrolysin, by modulating the permeability of the blood-brain barrier, blocks the development of neuroinflammation, reduces the accumulation of pathological forms of proteins and may be slow down the progression of neurodegeneration.<\/jats:p>","DOI":"10.17116\/jnevro202412401145","type":"journal-article","created":{"date-parts":[[2024,1,23]],"date-time":"2024-01-23T11:12:03Z","timestamp":1706008323000},"page":"45","source":"Crossref","is-referenced-by-count":4,"title":["Traumatic brain injury as risk factor of Alzheimer\u2019s disease and possibilities of pathogenetic therapy"],"prefix":"10.17116","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8988-3011","authenticated-orcid":false,"given":"I.V.","family":"Litvinenko","sequence":"first","affiliation":[{"name":"Kirov Military Medical Academy","place":["St. Petersburg, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7039-2423","authenticated-orcid":false,"given":"K.M.","family":"Naumov","sequence":"additional","affiliation":[{"name":"Kirov Military Medical Academy","place":["St. Petersburg, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3109-8795","authenticated-orcid":false,"given":"V.Yu.","family":"Lobzin","sequence":"additional","affiliation":[{"name":"Kirov Military Medical Academy","place":["St. Petersburg, Russia"]},{"name":"Mechnikov North-Western State Medical University","place":["St. Petersburg, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4723-802X","authenticated-orcid":false,"given":"A.Yu.","family":"Emelin","sequence":"additional","affiliation":[{"name":"Kirov Military Medical Academy","place":["St. Petersburg, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5006-8394","authenticated-orcid":false,"given":"P.S.","family":"Dynin","sequence":"additional","affiliation":[{"name":"Kirov Military Medical Academy","place":["St. Petersburg, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8657-1901","authenticated-orcid":false,"given":"K.A.","family":"Kolmakova","sequence":"additional","affiliation":[{"name":"Kirov Military Medical Academy","place":["St. Petersburg, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-1239-9796","authenticated-orcid":false,"given":"V.O.","family":"Nikishin","sequence":"additional","affiliation":[{"name":"Kirov Military Medical Academy","place":["St. Petersburg, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6743","reference":[{"key":"key-10.17116\/jnevro202412401145-1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jalz.2011.10.007"},{"key":"key-10.17116\/jnevro202412401145-2","unstructured":"Lobo A, Launer LJ, Fratiglioni L, et al. 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