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The range of target innovative agents in refractory MG includes monoclonal antibodies, which act directly on individual components of the complement system. Based on the results of randomized controlled trials, data on the effectiveness and safety of eculizumab, which inhibits the C5 component of the complement system, is presented. We present our own clinical experience of using eculizumab in a young woman with refractory generalized AChR-positive MG with a rapid decrease in the severity of symptoms to a minimum level and restoration of ability to work, and the absence of adverse events during therapy.<\/jats:p>","DOI":"10.17116\/jnevro202412407285","type":"journal-article","created":{"date-parts":[[2024,8,23]],"date-time":"2024-08-23T06:44:38Z","timestamp":1724395478000},"page":"85","source":"Crossref","is-referenced-by-count":0,"special_numbering":"Vyp. 2","title":["Experience of using eculizumab in refractory myasthenia gravis"],"prefix":"10.17116","volume":"124","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3484-6165","authenticated-orcid":false,"given":"S.B.","family":"Stepanova","sequence":"first","affiliation":[{"name":"South Ural State Medical University","place":["Chelyabinsk, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5848-7235","authenticated-orcid":false,"given":"M.I.","family":"Karpova","sequence":"additional","affiliation":[{"name":"South Ural State Medical University","place":["Chelyabinsk, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5799-7233","authenticated-orcid":false,"given":"A.F.","family":"Vasilenko","sequence":"additional","affiliation":[{"name":"South Ural State Medical University","place":["Chelyabinsk, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0000-3630-6130","authenticated-orcid":false,"given":"M.A.","family":"Domashenko","sequence":"additional","affiliation":[{"name":"Central Clinical Medical and Sanitary Unit","place":["Magnitogorsk, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/jnevro202412407285-1","doi-asserted-by":"publisher","DOI":"10.1038\/s41572-019-0079-y"},{"key":"key-10.17116\/jnevro202412407285-2","doi-asserted-by":"crossref","unstructured":"Hoffmann S, Harms L, Schuelke M, et al. 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