{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,3]],"date-time":"2026-05-03T02:08:14Z","timestamp":1777774094389,"version":"3.51.4"},"reference-count":30,"publisher":"Media Sphere Publishing House","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["S.S. Korsakov J. Neuro. Psych."],"published-print":{"date-parts":[[2026,4,29]]},"abstract":"<jats:p>Neurodegenerative diseases are often presented with myoclonus, sudden, short-term, involuntary muscle contractions (\u00abflinching\u00bb). According to the literature, myoclonus in Alzheimer\u2019s disease (AD) can occur up to 40\u201450% in cases of disease with early onset and in atypical forms. Importantly, epileptic myoclonus may indicate a risk of seizures with loss of consciousness, convulsions, and epileptiform activity, which may lead to more rapid progression of cognitive deficits. Diagnosis of myoclonus is essential for timely treatment and improving the quality of life of AD patients. The paper describes the main features of myoclonus in AD, the possibility of using additional examination methods, in particular video-electroencephalographic (video-EEG) monitoring for differential diagnosis and etiology clarification, and also presents a clinical case of a patient with AD and epileptic and non-epileptic myoclonus.<\/jats:p>","DOI":"10.17116\/jnevro202612604263","type":"journal-article","created":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:36:14Z","timestamp":1777484174000},"page":"63","source":"Crossref","is-referenced-by-count":0,"special_numbering":"Vyp. 2","title":["Myoclonus in Alzheimer\u2019s disease"],"prefix":"10.17116","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6327-3546","authenticated-orcid":false,"given":"A.N.","family":"Bogolepova","sequence":"first","affiliation":[{"name":"Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia","place":["Moscow, Russia"]},{"name":"Pirogov Russian National Research Medical University","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0804-7076","authenticated-orcid":false,"given":"S.G.","family":"Burd","sequence":"additional","affiliation":[{"name":"Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia","place":["Moscow, Russia"]},{"name":"Pirogov Russian National Research Medical University","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8712-4775","authenticated-orcid":false,"given":"A.V.","family":"Lebedeva","sequence":"additional","affiliation":[{"name":"Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia","place":["Moscow, Russia"]},{"name":"Pirogov Russian National Research Medical University","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3746-1797","authenticated-orcid":false,"given":"Yu.V.","family":"Rubleva","sequence":"additional","affiliation":[{"name":"Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0828-9868","authenticated-orcid":false,"given":"E.A.","family":"Kovalenko","sequence":"additional","affiliation":[{"name":"Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia","place":["Moscow, Russia"]},{"name":"Pirogov Russian National Research Medical University","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8606-5715","authenticated-orcid":false,"given":"E.V.","family":"Machnovich","sequence":"additional","affiliation":[{"name":"Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia","place":["Moscow, Russia"]},{"name":"Pirogov Russian National Research Medical University","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2313-571X","authenticated-orcid":false,"given":"N.A.","family":"Osinovskaya","sequence":"additional","affiliation":[{"name":"Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2730-7662","authenticated-orcid":false,"given":"N.V.","family":"Pantina","sequence":"additional","affiliation":[{"name":"Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8496-7475","authenticated-orcid":false,"given":"I.I.","family":"Kovaleva","sequence":"additional","affiliation":[{"name":"Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4753-1170","authenticated-orcid":false,"given":"T.A.","family":"Bokitko","sequence":"additional","affiliation":[{"name":"Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3015-1881","authenticated-orcid":false,"given":"G.A.","family":"Alexeeva","sequence":"additional","affiliation":[{"name":"Federal Center for Brain and Neurotechnologies of the Federal Medical Biological Agency of Russia","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/jnevro202612604263-1","doi-asserted-by":"publisher","DOI":"10.1016\/s1353-8020(02)00054-8"},{"key":"key-10.17116\/jnevro202612604263-2","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.5.1197"},{"key":"key-10.17116\/jnevro202612604263-3","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870130126"},{"key":"key-10.17116\/jnevro202612604263-4","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/117.4.835"},{"key":"key-10.17116\/jnevro202612604263-5","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120203"},{"key":"key-10.17116\/jnevro202612604263-6","doi-asserted-by":"publisher","DOI":"10.1002\/1531-8257(200001)15:1<77::aid-mds1013>3.0.co;2-n"},{"key":"key-10.17116\/jnevro202612604263-7","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870120633"},{"key":"key-10.17116\/jnevro202612604263-8","doi-asserted-by":"publisher","DOI":"10.1002\/mds.870090609"},{"key":"key-10.17116\/jnevro202612604263-9","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.60.3.523"},{"key":"key-10.17116\/jnevro202612604263-10","unstructured":"Bobylova MIu, Dunaevskaia GN. Myoclonus in children. S.S. Korsakov Journal of Neurology and Psychiatry. 2012;112(9):77-81. (In Russ.)"},{"key":"key-10.17116\/jnevro202612604263-11","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30044-3"},{"key":"key-10.17116\/jnevro202612604263-12","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-170031"},{"key":"key-10.17116\/jnevro202612604263-13","doi-asserted-by":"publisher","DOI":"10.1007\/BF00718016"},{"key":"key-10.17116\/jnevro202612604263-14","doi-asserted-by":"publisher","DOI":"10.1159\/000117218"},{"key":"key-10.17116\/jnevro202612604263-15","doi-asserted-by":"publisher","DOI":"10.1007\/s11910-020-01090-y"},{"key":"key-10.17116\/jnevro202612604263-16","doi-asserted-by":"publisher","DOI":"10.1016\/j.yebeh.2011.03.022"},{"key":"key-10.17116\/jnevro202612604263-17","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awm213"},{"key":"key-10.17116\/jnevro202612604263-18","doi-asserted-by":"publisher","DOI":"10.3233\/JAD-2012-111613"},{"key":"key-10.17116\/jnevro202612604263-19","doi-asserted-by":"publisher","DOI":"10.1016\/j.nrl.2014.12.008"},{"key":"key-10.17116\/jnevro202612604263-20","doi-asserted-by":"publisher","DOI":"10.1001\/archneur.1991.00530230049020"},{"key":"key-10.17116\/jnevro202612604263-21","doi-asserted-by":"publisher","DOI":"10.1177\/1533317518813551"},{"key":"key-10.17116\/jnevro202612604263-22","doi-asserted-by":"publisher","DOI":"10.1016\/j.seizure.2022.03.005"},{"key":"key-10.17116\/jnevro202612604263-23","doi-asserted-by":"publisher","DOI":"10.1136\/jnnp.48.6.506"},{"key":"key-10.17116\/jnevro202612604263-24","doi-asserted-by":"publisher","DOI":"10.1097\/00002093-199040400-00003"},{"key":"key-10.17116\/jnevro202612604263-25","doi-asserted-by":"publisher","DOI":"10.1177\/1060028014550334"},{"key":"key-10.17116\/jnevro202612604263-26","doi-asserted-by":"publisher","DOI":"10.1097\/01.jcp.0000264995.31771.05"},{"key":"key-10.17116\/jnevro202612604263-27","doi-asserted-by":"publisher","DOI":"10.1212\/wnl.34.7.898"},{"key":"key-10.17116\/jnevro202612604263-28","doi-asserted-by":"publisher","DOI":"10.1007\/s13311-013-0216-3"},{"key":"key-10.17116\/jnevro202612604263-29","doi-asserted-by":"publisher","DOI":"10.1016\/S1353-8020(08)70033-6"},{"key":"key-10.17116\/jnevro202612604263-30","doi-asserted-by":"publisher","DOI":"10.1016\/B978-0-444-64142-7.00046-1"}],"container-title":["S.S. Korsakov Journal of Neurology and Psychiatry"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T17:36:38Z","timestamp":1777484198000},"score":1,"resource":{"primary":{"URL":"https:\/\/mediasphera.ru\/issues\/zhurnal-nevrologii-i-psikhiatrii-im-s-s-korsakova-2\/2026\/4-2\/1199772982026042063"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,29]]},"references-count":30,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2026,4,29]]}},"alternative-id":["10.17116\/jnevro202612604263"],"URL":"https:\/\/doi.org\/10.17116\/jnevro202612604263","relation":{},"ISSN":["1997-7298"],"issn-type":[{"value":"1997-7298","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4,29]]}}}