{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T07:37:09Z","timestamp":1771486629402,"version":"3.50.1"},"reference-count":17,"publisher":"Media Sphere Publishing House","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Burdenko's Journal of Neurosurgery"],"published-print":{"date-parts":[[2023,2,13]]},"abstract":"<jats:p>Introduction. Stereotactic radiosurgery is one of the main treatments for vestibular schwannomas (VS). Their feature is frequent post-radiation pseudoprogression. This may be due to hormonal status of patients. Objective. To analyze expression of progesterone and estrogen receptors in women and men with VS. Material and methods. Immunohistochemical analysis of expression of progesterone (PR) and estrogen receptors (ER) after biopsy was performed in 240 patients with VS between 2018 and 2021. ER\/PR expression was assessed in men (n=120) and women (n=120) in 3 age subgroups: young age (18\u201444 years), middle age (45\u201459 years) and old age (60\u201479 years). Each subgroup included 40 patients. Statistical analysis was performed using the Mann\u2014Whitney test and MedCalc software. Results. ER expression is not typical for VS (men \u2014 1 (0.01%), women \u2014 3 (2.5%)). At the same time, PR expression was found in 29 (24.2%) men and 21 (17.5%) women. We found no significant difference in expression of ER and PR between men and women. However, variability in PR expression was revealed, i.e. predominance of this indicator in young women (p=0.0463) and middle-aged men (p=0.0110). Expression of PR was similar in elderly patients (p=0.2382). Conclusion. The established incidence of PR expression may be one of the probable causes affecting development and duration of VS pseudoprogression after radiosurgery without clear relationship between sex and age. Further prospective research is needed to predict the risks of pseudoprogression.<\/jats:p>","DOI":"10.17116\/neiro20238701144","type":"journal-article","created":{"date-parts":[[2023,2,10]],"date-time":"2023-02-10T18:23:23Z","timestamp":1676053403000},"page":"44","source":"Crossref","is-referenced-by-count":2,"title":["Expression of estrogen and progesterone receptors in vestibular schwannomas"],"prefix":"10.17116","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1572-5798","authenticated-orcid":false,"given":"S.R.","family":"Ilyalov","sequence":"first","affiliation":[{"name":"Gamma Clinic center of high precision radiology (Gamma Medtechnology LLC)","place":["Obninsk, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7206-6365","authenticated-orcid":false,"given":"M.V.","family":"Ryzhova","sequence":"additional","affiliation":[{"name":"Burdenko Neurosurgical Center","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1436-0010","authenticated-orcid":false,"given":"M.V.","family":"Galkin","sequence":"additional","affiliation":[{"name":"Burdenko Neurosurgical Center","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6510-7883","authenticated-orcid":false,"given":"S.M.","family":"Banov","sequence":"additional","affiliation":[{"name":"Burdenko Neurosurgical Center","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0976-4547","authenticated-orcid":false,"given":"A.V.","family":"Golanov","sequence":"additional","affiliation":[{"name":"Burdenko Neurosurgical Center","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9811-9442","authenticated-orcid":false,"given":"D.Yu.","family":"Usachev","sequence":"additional","affiliation":[{"name":"Burdenko Neurosurgical Center","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/neiro20238701144-1","doi-asserted-by":"publisher","DOI":"10.17116\/neiro20228602155"},{"key":"key-10.17116\/neiro20238701144-2","doi-asserted-by":"publisher","DOI":"10.1093\/neuros\/nyy019"},{"key":"key-10.17116\/neiro20238701144-3","doi-asserted-by":"publisher","DOI":"10.1177\/0194599819893106"},{"key":"key-10.17116\/neiro20238701144-4","doi-asserted-by":"publisher","DOI":"10.1016\/0090-3019(83)90201-x"},{"key":"key-10.17116\/neiro20238701144-5","unstructured":"Whittle IR, Hawkins RA, Miller JD. Sex hormone receptors in intracranial tumours and normal brain. European Journal of Surgical Oncology. 1987;13(4):303-307"},{"key":"key-10.17116\/neiro20238701144-6","unstructured":"De Campos Guti\u00e9rrez JM, Ramos Duce F, G\u00f3mez Lopez PA, Kusak Lambea ME, Boixad\u00f3s Servat JR. Receptores especificos de hormonas sexuales en tumores del sistema nervioso central. Revista espanola de oncologia. 1984;31(2):289-297"},{"key":"key-10.17116\/neiro20238701144-7","doi-asserted-by":"publisher","DOI":"10.1097\/pai.0000000000000318"},{"key":"key-10.17116\/neiro20238701144-8","doi-asserted-by":"publisher","DOI":"10.1007\/s10552-011-9742-7"},{"key":"key-10.17116\/neiro20238701144-9","doi-asserted-by":"publisher","DOI":"10.1288\/00005537-199507000-00005"},{"key":"key-10.17116\/neiro20238701144-10","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6700475"},{"key":"key-10.17116\/neiro20238701144-11","doi-asserted-by":"publisher","DOI":"10.1186\/s12893-020-00903-8"},{"key":"key-10.17116\/neiro20238701144-12","doi-asserted-by":"publisher","DOI":"10.1080\/01676830.2020.1747498"},{"key":"key-10.17116\/neiro20238701144-13","unstructured":"Siglock TJ, Rosenblatt SS, Finck F, House WF, Hitselberger WE. Sex hormone receptors in acoustic neuromas. The American Journal of Otology. 1990;11(4):237-239"},{"key":"key-10.17116\/neiro20238701144-14","doi-asserted-by":"publisher","DOI":"10.1038\/pcan.2013.45"},{"key":"key-10.17116\/neiro20238701144-15","doi-asserted-by":"publisher","DOI":"10.1097\/mao.0b013e3181feb92a"},{"key":"key-10.17116\/neiro20238701144-16","doi-asserted-by":"publisher","DOI":"10.1097\/mlg.0b013e318177e20b"},{"key":"key-10.17116\/neiro20238701144-17","doi-asserted-by":"publisher","DOI":"10.1186\/1477-5751-8-9"}],"container-title":["Burdenko's Journal of Neurosurgery"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T09:01:55Z","timestamp":1745485315000},"score":1,"resource":{"primary":{"URL":"https:\/\/mediasphera.ru\/issues\/zhurnal-voprosy-nejrokhirurgii-imeni-n-n-burdenko\/2023\/1\/1004288172023011044"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2,13]]},"references-count":17,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2023,2,13]]}},"alternative-id":["10.17116\/neiro20238701144"],"URL":"https:\/\/doi.org\/10.17116\/neiro20238701144","relation":{},"ISSN":["0042-8817"],"issn-type":[{"value":"0042-8817","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2,13]]}}}