{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:22:49Z","timestamp":1747200169727,"version":"3.40.5"},"reference-count":17,"publisher":"Media Sphere Publishing House","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Burdenko's Journal of Neurosurgery"],"published-print":{"date-parts":[[2023,8,31]]},"abstract":"<jats:p>The concept of post-traumatic skull defect closure is based on restoration of anatomical relationships for the maximum possible recovery of brain function, i.e. it is considered as a stage of surgical rehabilitation. The choice of implants in pediatric patients is limited. In this regard, the \u00abgold standard\u00bb is still autologous bone implant. Material and methods. We propose a method for storage and sterilization of autologous bone implant. The last one implies keeping at a temperature of \u201380 \u02daC with sterilization in a vacuum chamber filled with hydrogen peroxide vapors of biocidal plasma medium. Sterilization is provided by 45-minute cycle immediately before surgery. We report skull defect closure using autologous bone implants in 79 patients. Evaluation of effectiveness of storage and sterilization of autologous bone implant included analysis of mechanical properties of bone after sterilization, intra-operative microbiological monitoring, incidence of infections in early postoperative period, follow-up with assessment of resorption. Results. Early infectious complications occurred in 2 patients (2.5%). Complete resorption with redo surgery occurred in 6 (10.1%) cases. Sterilization in low-temperature plasma of hydrogen peroxide changes mechanical properties of the bone, increases durability under compressive stresses and decreases durability under tensile conditions. This does not affect functional tasks of autologous bone. The proposed method of storage and sterilization is accompanied by low risk of infections and resorption. Storage of autologous bone implant at a temperature of \u201380 \u02daC with subsequent sterilization in low-temperature plasma of hydrogen peroxide can be considered as a safe and effective method for skull defect closure in children after decompressive surgery.<\/jats:p>","DOI":"10.17116\/neiro20238704158","type":"journal-article","created":{"date-parts":[[2023,8,31]],"date-time":"2023-08-31T09:09:30Z","timestamp":1693472970000},"page":"58","source":"Crossref","is-referenced-by-count":0,"title":["Autologous bone implant for recunstructive surgery after decompressive craniectomy in children"],"prefix":"10.17116","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2018-050X","authenticated-orcid":false,"given":"Zh.B.","family":"Semenova","sequence":"first","affiliation":[{"name":"Research Institute of Emergency Pediatric Surgery and Traumatology","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9048-8083","authenticated-orcid":false,"given":"A.I.","family":"Salimon","sequence":"additional","affiliation":[{"name":"Skoltech","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3558-5198","authenticated-orcid":false,"given":"A.M.","family":"Korsunsky","sequence":"additional","affiliation":[{"name":"Skoltech","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.V.","family":"Melnikov","sequence":"additional","affiliation":[{"name":"Research Institute of Emergency Pediatric Surgery and Traumatology","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu.A.","family":"Sadykova","sequence":"additional","affiliation":[{"name":"Skoltech","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"A.V.","family":"Marshintsev","sequence":"additional","affiliation":[{"name":"Research Institute of Emergency Pediatric Surgery and Traumatology","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E.S.","family":"Statnik","sequence":"additional","affiliation":[{"name":"Skoltech","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"V.I.","family":"Lukyanov","sequence":"additional","affiliation":[{"name":"Research Institute of Emergency Pediatric Surgery and Traumatology","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/neiro20238704158-1","unstructured":"Semenova ZhB. The concept of restorative treatment \u00abstep-by-step\u00bb at the stage of early neurorehabilitation in children with PMT. The view of a pediatric neurosurgeon. Russian Neurosurgical Journal named after A.L. Polenov. 2019;11(1):72-79. (In Russ.)"},{"key":"key-10.17116\/neiro20238704158-2","doi-asserted-by":"publisher","DOI":"10.3171\/2018.3.PEDS17234"},{"key":"key-10.17116\/neiro20238704158-3","doi-asserted-by":"publisher","DOI":"10.3171\/2012.6.PEDS1268"},{"key":"key-10.17116\/neiro20238704158-4","unstructured":"Ivanov OV, Semichev EV, Shnyakin PG, Sobakar EG. Plastic skull defects: from auto-resistance to modern biomaterials (literature review). Medical science and education of the Urals. 2018;19(3):143-149. (In Russ.)"},{"key":"key-10.17116\/neiro20238704158-5","doi-asserted-by":"crossref","unstructured":"Konovalov AN, Pilipenko YuV, Eliava ShSh. 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