{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,11]],"date-time":"2026-06-11T07:29:26Z","timestamp":1781162966240,"version":"3.54.1"},"reference-count":9,"publisher":"Media Sphere Publishing House","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Burdenko's Journal of Neurosurgery"],"published-print":{"date-parts":[[2023,10,13]]},"abstract":"<jats:p>Currently, there is no effective method of treating complete spinal cord intersection. One of the promising experimental approaches is substances promoting repair and fusion of axonal membranes. Objective. To study clinical and functional recovery in experimental animals with transected spinal cord after management with photo-cross-linked chitosan in a homogeneous mixture with polyethylene glycol. Material and methods. We studied 20 rabbits with a model of complete spinal cord transection at the level of Th9. There were control and experimental groups (n=10; n=10). In the experimental group, we intraoperatively injected photo-cross-linked chitosan in a homogeneous mixture with polyethylene glycol. Neurological status was assessed using the modified Basso Beattie Bresnahan scale. Histological examination was performed after removing the animals from the experiment. Results. In the experimental group, significant regression of neurological disorders was accompanied by partial recovery of movements, sensitivity and control of pelvic functions by the 30th day of the experiment. There was no mortality in the experimental group. Paraplegia and anesthesia persisted in the control group while mortality was 40% (n=4). Histological analysis in the main group revealed axonal \u00abbridges\u00bb in the area of injury and spread of DiI dye through this area. Conclusion. These phenomena confirm the positive effect of chitosan and polyethylene glycol on functional recovery after experimental spinal cord injury. These data are consistent with histological findings.<\/jats:p>","DOI":"10.17116\/neiro20238705136","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T11:32:42Z","timestamp":1697196762000},"page":"36","source":"Crossref","is-referenced-by-count":6,"title":["Recovery of spinal cord functions after experimental complete crossection under the effect of chitosan polymeric compounds"],"prefix":"10.17116","volume":"87","author":[{"given":"M.V.","family":"Lebenstein-Gumovski","sequence":"first","affiliation":[{"name":"Stavropol State Medical University","place":["Stavropol, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4374-6593","authenticated-orcid":false,"given":"R.M.","family":"Bashakhanov","sequence":"additional","affiliation":[{"name":"Stavropol State Medical University","place":["Stavropol, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9366-5647","authenticated-orcid":false,"given":"D.A.","family":"Kovalev","sequence":"additional","affiliation":[{"name":"Stavropol Research Institute for Plague Control","place":["Stavropol, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7698-7361","authenticated-orcid":false,"given":"A.M.","family":"Zhirov","sequence":"additional","affiliation":[{"name":"Stavropol Research Institute for Plague Control","place":["Stavropol, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.A.","family":"Shatohkin","sequence":"additional","affiliation":[{"name":"Stavropol State Medical University","place":["Stavropol, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-7993-0900","authenticated-orcid":false,"given":"V.S.","family":"Botasheva","sequence":"additional","affiliation":[{"name":"Stavropol State Medical University","place":["Stavropol, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3515-8329","authenticated-orcid":false,"given":"A.A.","family":"Grin","sequence":"additional","affiliation":[{"name":"Sklifosovsky Research Institute for Emergency Care","place":["Moscow, Russia"]},{"name":"Pirogov Russian National Research Medical University","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6743","reference":[{"key":"key-10.17116\/neiro20238705136-1","doi-asserted-by":"publisher","DOI":"10.1093\/burnst\/tkab035"},{"key":"key-10.17116\/neiro20238705136-2","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18020466"},{"key":"key-10.17116\/neiro20238705136-3","doi-asserted-by":"crossref","unstructured":"Canavero S. HEAVEN: The head anastomosis venture Project outline for the first human head transplantation with spinal linkage (GEMINI). Surgical Neurology International. 2013;4:335-342","DOI":"10.4103\/2152-7806.113444"},{"key":"key-10.17116\/neiro20238705136-4","doi-asserted-by":"publisher","DOI":"10.1179\/1743132812Y.0000000133"},{"key":"key-10.17116\/neiro20238705136-5","doi-asserted-by":"publisher","DOI":"10.4103\/1673-5374.235301"},{"key":"key-10.17116\/neiro20238705136-6","doi-asserted-by":"publisher","DOI":"10.1126\/science.1175737"},{"key":"key-10.17116\/neiro20238705136-7","unstructured":"European Convention for the Protection of Vertebrate Animals used for Experimental and Other Scientific Purposes (EST No. 123). Strasbourg; 1986"},{"key":"key-10.17116\/neiro20238705136-8","doi-asserted-by":"crossref","unstructured":"Basso DM, Beattie MS, Bresnahan JC. A sensitive and reliable locomotor rating scale for open field testing in rats. Journal of Neurotrauma. 1995;12(1):21","DOI":"10.1089\/neu.1995.12.1"},{"key":"key-10.17116\/neiro20238705136-9","unstructured":"Lebenstein-Gumovski MV, Botasheva VS, Kovalev DA, Shatokhin AA. Characterization of morphological and functional changes in the spinal cord after its intersection, under the influence of a hydrogel based on the modification of chitosan. Volgogradskii nauchno-medicinkii zhurnal. 2021;3(1):37-42. (In Russ.)"}],"container-title":["Burdenko's Journal of Neurosurgery"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T09:02:20Z","timestamp":1745485340000},"score":1,"resource":{"primary":{"URL":"https:\/\/mediasphera.ru\/issues\/zhurnal-voprosy-nejrokhirurgii-imeni-n-n-burdenko\/2023\/5\/1004288172023051036"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,10,13]]},"references-count":9,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2023,10,13]]}},"alternative-id":["10.17116\/neiro20238705136"],"URL":"https:\/\/doi.org\/10.17116\/neiro20238705136","relation":{},"ISSN":["0042-8817"],"issn-type":[{"value":"0042-8817","type":"print"}],"subject":[],"published":{"date-parts":[[2023,10,13]]}}}