{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T17:30:36Z","timestamp":1790962236288,"version":"4.1.0"},"reference-count":23,"publisher":"Media Sphere Publishing House","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Burdenko's Journal of Neurosurgery"],"published-print":{"date-parts":[[2023,10,13]]},"abstract":"<jats:p>Background. Pathogenesis of peritumoral cerebral edema is unclear and potentially associated with glymphatic system dysfunction. Diffusion tensor MRI (DT-MRI) with analysis of ALPS (Analysis along the Perivascular Space) index may be valuable for assessment of edema. This approach visualizes fluid flow along perivascular spaces of deep cerebral veins. Objective. To assess glymphatic system function in supratentorial tumors and healthy volunteers using DT-MRI. Material and methods. There were 52 patients (59% men) aged 43 (28\u201464) years with supratentorial tumors (meningioma \u2014 20, grade 3\u20144 glioma \u2014 15, metastases \u2014 9, lymphoma \u2014 8). Tumors and perifocal edema did not involve deep cerebral veins. The control group included 6 healthy volunteers aged 34-66 years. MRI protocol (Signa HDxt, 3 T) contained standard T1, T2, T2FLAIR, DWI and post-contrast T1 (3D BRAVO). DT-MRI had the following parameters: TR=10 000 ms, TEmin=102 ms, FOV=240 mm, isotropic voxel size 3\u00d73\u00d73 mm3, 60 directions of diffusion gradients. Measurements were carried out at b-factor 0 and 1000 s\/mm2. Analysis was carried out in the ReadyView software. Results. Right- and left-sided ALPS indices were similar in the control group (p=0.917). Perifocal edema (regardless of histological type of tumor) in the ipsilateral hemisphere was accompanied by significantly lower ALPS index (p&lt;0.005), while these values in contralateral (intact) hemisphere were similar in both groups (p=0.7). Conclusion. We found significantly lower ALPS index in deep parts of the affected hemisphere in patients with perifocal edema. These data can indicate the role of glymphatic system dysfunction in pathogenesis of this pathology.<\/jats:p>","DOI":"10.17116\/neiro20238705145","type":"journal-article","created":{"date-parts":[[2023,10,13]],"date-time":"2023-10-13T11:32:42Z","timestamp":1697196762000},"page":"45","source":"Crossref","is-referenced-by-count":3,"title":["Perifocal edema and glymphatic system dysfunction: quantitative assessment based on diffusion tensor magnetic resonance imaging"],"prefix":"10.17116","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9010-3059","authenticated-orcid":false,"given":"A.M.","family":"Turkin","sequence":"first","affiliation":[{"name":"Burdenko Neurosurgical Center","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6760-9505","authenticated-orcid":false,"given":"T.V.","family":"Melnikova-Pitskhelauri","sequence":"additional","affiliation":[{"name":"Burdenko Neurosurgical 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