{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:22:51Z","timestamp":1747200171652,"version":"3.40.5"},"reference-count":15,"publisher":"Media Sphere Publishing House","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Burdenko's Journal of Neurosurgery"],"published-print":{"date-parts":[[2023,12,6]]},"abstract":"<jats:p>Background. Treatment of acromegaly is still an unresolved problem. Overall postoperative remission rate ranges from 34 to 85%. These values are better for microadenomas (75\u201490%) and worse for macroadenomas (45\u201470%). Identification of predictors of acromegaly remission after surgical treatment is an urgent objective to improve the quality of medical care for these patients. Objective. To analyze postoperative freedom from acromegaly and predictors of remission. Material and methods. A retrospective single-center study included 227 patients with acromegaly who underwent resection of pituitary adenoma between August 2018 and August 2021. Results. Remission (normalization of serum IGF-1) was achieved in 65 (55%) patients. Growth hormone and IGF-1 index decreased after surgery in all patients. Mean preoperative serum growth hormone was 12.45 [6.88, 29.85] ng\/ml, early postoperative concentration \u2014 1.54 [0.80, 3.38] ng\/ml, in delayed period \u2014 1.15 [0.57, 3.80] ng\/ml. Mean IGF-1 index was 2.18 [1.69, 2.71], 1.47 [0.99, 1.90] and 0.99 [0.74, 1.43], respectively. Conclusion. Significant predictors of acromegaly remission after neurosurgical treatment were age, preoperative level of growth hormone, tumor size and location, growth hormone and IGF-1 index in early postoperative period and residual tumor after surgery. Multivariate analysis revealed a significant association of acromegaly remission with small tumor size, low postoperative level of growth hormone and no residual tumor within 3\u20146 month after surgery.<\/jats:p>","DOI":"10.17116\/neiro20238706176","type":"journal-article","created":{"date-parts":[[2023,12,6]],"date-time":"2023-12-06T09:14:21Z","timestamp":1701854061000},"page":"76","source":"Crossref","is-referenced-by-count":0,"title":["Predictors of postoperative remission of acromegaly. 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