{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,6,23]],"date-time":"2025-06-23T15:27:00Z","timestamp":1750692420652,"version":"3.40.5"},"reference-count":18,"publisher":"Media Sphere Publishing House","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Burdenko's Journal of Neurosurgery"],"published-print":{"date-parts":[[2024,4,23]]},"abstract":"<jats:p>Background. Craniosynostosis (CS) is a group of skull malformations manifested by congenital absence or premature closure of cranial sutures. Reconstructive surgery in the second half of life is traditional approach for CS. The issues of surgical stress response after reconstructive surgery for CS in children are still unclear. Objective. To evaluate clinical and laboratory parameters in children undergoing traumatic reconstructive surgery for CS. Material and methods. Inclusion criteria were CS, reconstructive surgery, age &lt;24 months, no comorbidities and available laboratory diagnostic protocol including complete blood count, biochemical blood test with analysis of C-reactive protein, procalcitonin, ferritin and presepsin. The study included 32 patients (24 (75%) boys and 8 (25%) girls) aged 10.29\u00b14.99 months after surgery between October 2021 and June 2022. Non-syndromic and syndromic forms of CS were observed in 25 (78.1%) and 7 (21.9%) cases, respectively. Results. There were no infectious complications. We analyzed postoperative clinical data, fever, clinical and biochemical markers of inflammation. Conclusion. Early postoperative period after reconstructive surgery for CS in children is accompanied by significant increase of inflammatory markers (C-reactive protein, procalcitonin, ferritin). However, these findings do not indicate infectious complications. This is a manifestation of nonspecific systemic reaction. Severity of systemic inflammatory response syndrome with increase in acute phase proteins indicates highly traumatic reconstructive surgery for CS in children. Analysis of serum presepsin allows for differential diagnosis between infectious complication and uncomplicated course of early postoperative period.<\/jats:p>","DOI":"10.17116\/neiro20248801170","type":"journal-article","created":{"date-parts":[[2024,2,9]],"date-time":"2024-02-09T15:50:11Z","timestamp":1707493811000},"page":"70","source":"Crossref","is-referenced-by-count":3,"title":["Prospective analysis of inflammatory markers and perioperative clinical data in children with craniosynostosis undergoing reconstructive surgery"],"prefix":"10.17116","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5559-2678","authenticated-orcid":false,"given":"B.A.","family":"Bashiryan","sequence":"first","affiliation":[{"name":"Burdenko Neurosurgical Center","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9850-050X","authenticated-orcid":false,"given":"O.A.","family":"Gadzhieva","sequence":"additional","affiliation":[{"name":"Burdenko Neurosurgical Center","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2051-1855","authenticated-orcid":false,"given":"L.A.","family":"Satanin","sequence":"additional","affiliation":[{"name":"Burdenko Neurosurgical Center","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-8477-9564","authenticated-orcid":false,"given":"E.A.","family":"Lavrenyuk","sequence":"additional","affiliation":[{"name":"Burdenko Neurosurgical Center","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4247-8953","authenticated-orcid":false,"given":"V.A.","family":"Tere","sequence":"additional","affiliation":[{"name":"Burdenko Neurosurgical Center","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0428-0498","authenticated-orcid":false,"given":"N.A.","family":"Mazerkina","sequence":"additional","affiliation":[{"name":"Burdenko Neurosurgical Center","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5119-6814","authenticated-orcid":false,"given":"A.V.","family":"Sakharov","sequence":"additional","affiliation":[{"name":"Burdenko Neurosurgical Center","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8970-5303","authenticated-orcid":false,"given":"I.V.","family":"Getmanova","sequence":"additional","affiliation":[{"name":"Burdenko Neurosurgical Center","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0549-855X","authenticated-orcid":false,"given":"V.V.","family":"Roginsky","sequence":"additional","affiliation":[{"name":"Central Research Institute of Dental and Maxillofacial Surgery","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/neiro20248801170-1","unstructured":"Roginsky VV, Khachatryan VA, Satanin LA, Kim AV, Ivanov VP, Samochernykh KA, Solonichenko VG, Glagolev NV, Zemlyanikin VV, Ivanov AL, Kabanyan AB, Letyagin GV, Pak OI, Semenova ZhB, Timershin AG, Shamkhalov HSh, Sakharov AV, Iova AS. 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