{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,30]],"date-time":"2025-05-30T11:24:47Z","timestamp":1748604287554,"version":"3.40.5"},"reference-count":27,"publisher":"Media Sphere Publishing House","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Burdenko's Journal of Neurosurgery"],"published-print":{"date-parts":[[2024,4,23]]},"abstract":"<jats:p>Cerebral aneurysms are diagnosed in 1-5% of people and cause 80-85% of subarachnoid hemorrhages (SAH). Aneurysmal hemorrhages are more common in people aged 30-50 years causing high socio-economic significance of this disease. Therefore, the outcomes of microsurgical clipping are an urgent problem in these patients. Objective. To evaluate the immediate and long-term results after microsurgical treatment of cerebral aneurysms in acute period of hemorrhage; to analyze functional results and long-term outcomes, including higher mental functions and return to previous work. Material and methods. The study included 517 patients in acute period of subarachnoid hemorrhage between 2019 and 2022. Severity of hemorrhage was assessed using the Hunt-Hess scale while the Fisher scale was valuable to estimate dimensions of hemorrhage and predictions for vasospasm. All patients underwent microsurgical clipping of aneurysms. We assessed clinical status and outcomes immediately after microsurgical clipping, within 2 weeks, 1, 3, 6 and 12 months after surgery. The Modified Glasgow Outcome Scale, Modified Rankin Scale (mRS), EQ-5D-3L Quality of Life Questionnaire, Mini-Mental State Examination MMSE and Hamilton Anxiety Rating Scale were used. Results. After 1 month, mRS score 0 was observed in 22% of patients, score 1 \u2014 17%, score 2 \u2014 19.4%, score 3 \u2014 6.2%, score 4 \u2014 2.6%, score 5 \u2014 1% of patients. Mortality rate was 6.4%. After 12 months, mRS score 0, 1, 2, 3 and 4 was observed in 67%, 15%, 8%, 3% and 0.4% of patients, respectively. After 12 months, 39 (8.3%) patients did not return to previous work. Among 427 (91.7%) patients who returned to previous work, 20% returned to work after 3 months, 65% after 6 months and 15% after 9 months. Conclusion. Short-term and long-term functional outcomes vary significantly. There were significantly better mRS scores in long-term period compared to early period. Analysis of immediate and long-term results after hemorrhage will allow us to determine the most important predictors of adverse functional outcomes, assess the prevalence, characteristics, modifiable risk factors and consequences of hemorrhage.<\/jats:p>","DOI":"10.17116\/neiro20248805130","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T15:00:41Z","timestamp":1729263641000},"page":"30","source":"Crossref","is-referenced-by-count":1,"title":["Immediate and long-term results after microsurgical clipping of ruptured aneurysms in acute period of hemorrhage"],"prefix":"10.17116","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0009-0002-3618-1029","authenticated-orcid":false,"given":"M.I.","family":"Derkach","sequence":"first","affiliation":[{"name":"Vladimirsky Moscow Regional Research Clinical Institute","place":["Moscow, Russia"]},{"name":"Russian Medical Academy for Continuous Professional Education","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3283-9524","authenticated-orcid":false,"given":"R.S.","family":"Dzhindzhikhadze","sequence":"additional","affiliation":[{"name":"Vladimirsky Moscow Regional Research Clinical Institute","place":["Moscow, Russia"]},{"name":"Russian Medical Academy for Continuous Professional Education","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7413-1968","authenticated-orcid":false,"given":"A.V.","family":"Polyakov","sequence":"additional","affiliation":[{"name":"Vladimirsky Moscow Regional Research Clinical Institute","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0987-3436","authenticated-orcid":false,"given":"A.D.","family":"Zaitsev","sequence":"additional","affiliation":[{"name":"Vladimirsky Moscow Regional Research Clinical Institute","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9083-9293","authenticated-orcid":false,"given":"G.Yu.","family":"Strakhov","sequence":"additional","affiliation":[{"name":"Russian Medical Academy for Continuous Professional Education","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9663-0960","authenticated-orcid":false,"given":"V.A.","family":"Lazarev","sequence":"additional","affiliation":[{"name":"Russian Medical Academy for Continuous Professional Education","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/neiro20248805130-1","doi-asserted-by":"crossref","unstructured":"Krylov VV, Konovalov AN, Dash\u2019yan VG, Kondakov EN, Tanyashin SV, Gorelyshev SK, Dreval\u2019 ON, Grin\u2019 AA, Parfenov VE, Kushniruk PI, Gulyaev DA, Kolotvinov VS, Rzaev DA, Poshataev KE, Kravets LY, Mozheiko RA, Kas\u2019yanov VA, Malyshev OB, Kordonskiy AYu, Trifonov IS, Kalandari AA, Shatokhin TA, Airapetyan AA, Dalibaldyan VA, Grigor\u2019ev IV, Sytnik AV. The current state of neurosurgery In Russian Federation. Russian Journal of Neurosurgery. 2016;3:3-44. (In Russ.)","DOI":"10.17116\/neiro20178075-12"},{"key":"key-10.17116\/neiro20248805130-2","doi-asserted-by":"publisher","DOI":"10.1016\/S0140-6736(16)30668-7"},{"key":"key-10.17116\/neiro20248805130-3","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-024-46015-2"},{"key":"key-10.17116\/neiro20248805130-4","doi-asserted-by":"crossref","unstructured":"Greving JP, Wermer MJ, Brown RD Jr, Morita A, Juvela S, Yonekura M, Ishibashi T, Torner JC, Nakayama T, Rinkel GJ, Algra A. Development of the PHASES score for prediction of risk of rupture of intracranial aneurysms: a pooled analysis of six prospective cohort studies. Lancet Neurology. 2014;13(1):59-66","DOI":"10.1016\/S1474-4422(13)70263-1"},{"key":"key-10.17116\/neiro20248805130-5","unstructured":"Krylov VV. Neurosurgery and neuroreanimatology. M.: ABV-press; 2018. (In Russ.)"},{"key":"key-10.17116\/neiro20248805130-6","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMcp1605827"},{"key":"key-10.17116\/neiro20248805130-7","doi-asserted-by":"publisher","DOI":"10.1227\/NEU.0000000000001042"},{"key":"key-10.17116\/neiro20248805130-8","unstructured":"Konovalov AN, Krylov VV, Filatov YM, Eliava ShSh, Belousova OB, Tkachev VV, Parfenov VE, Svistov DV, Antonov GI, Lazarev VA, Ivanova NE, Piradov MA, Pirskaya TN, Lapatukhin VG, Skorokhod AA, Kurdyumova NV, Lubnin AYu, Tseitlin AM. A recommendation steamer for the management of patients with subarachnoid hemorrhage due to rupture of brain aneurysms. Burdenko\u2019s Journal of Neurosurgery. 2006;3:3-11. (In Russ.)"},{"key":"key-10.17116\/neiro20248805130-9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jstrokecerebrovasdis.2019.06.038"},{"key":"key-10.17116\/neiro20248805130-10","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.118.023902"},{"key":"key-10.17116\/neiro20248805130-11","unstructured":"Shetova IM, Dashyan VG, Lukyanchikov VA, Polunina NA, Matveev PD, Stadler VD, Belyakov LV, Krylov VV. Long-term results of surgical treatment of cerebral aneurysms in the acute period of hemorrhage. The Russian Neurosurgical Journal named after Professor A.L. Polenov. 2021;13(S1):204. (In Russ.)"},{"key":"key-10.17116\/neiro20248805130-12","doi-asserted-by":"publisher","DOI":"10.1161\/STROKEAHA.117.019328"},{"key":"key-10.17116\/neiro20248805130-13","unstructured":"Novikova ES. The results of surgical treatment of arterial aneurysms of the brain. Smolensk Medical Almanac. 2016;1:164-166. (In Russ.)"},{"key":"key-10.17116\/neiro20248805130-14","unstructured":"Lyunkova RN, Krylov VV. Complex arterial aneurysms of the brain. Modern treatment strategy. Neurosurgery. 2015;4:82-97. (In Russ.)"},{"key":"key-10.17116\/neiro20248805130-15","doi-asserted-by":"publisher","DOI":"10.1227\/01.neu.0000333794.13844.d9"},{"key":"key-10.17116\/neiro20248805130-16","doi-asserted-by":"publisher","DOI":"10.1007\/s12028-019-00737-0"},{"key":"key-10.17116\/neiro20248805130-17","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-013-1823-9"},{"key":"key-10.17116\/neiro20248805130-18","doi-asserted-by":"publisher","DOI":"10.1007\/s00701-015-2480-y"},{"key":"key-10.17116\/neiro20248805130-19","doi-asserted-by":"publisher","DOI":"10.15372\/SSMJ20200314"},{"key":"key-10.17116\/neiro20248805130-20","doi-asserted-by":"crossref","unstructured":"Lovelock CE, Rinkel GJ, Rothwell PM. Time trends in outcome of suba- rachnoid hemorrhage: population-based study and systematic review. Neurology. 2010;74(19):1494-1501","DOI":"10.1212\/WNL.0b013e3181dd42b3"},{"key":"key-10.17116\/neiro20248805130-21","doi-asserted-by":"crossref","unstructured":"Al-Khindi T, Macdonald RL, Schweizer TA. Cognitive and functional outcome after aneurysmal subarachnoid hemorrhage. Stroke. 2010;41(8): e519-e536","DOI":"10.1161\/STROKEAHA.110.581975"},{"key":"key-10.17116\/neiro20248805130-22","doi-asserted-by":"publisher","DOI":"10.3171\/2012.3.jns11706"},{"key":"key-10.17116\/neiro20248805130-23","doi-asserted-by":"publisher","DOI":"10.20333\/25000136-2022-5-28-32"},{"key":"key-10.17116\/neiro20248805130-24","unstructured":"Surgical treatment of cerebral aneurysms in the acute period of hemorrhage. Eliava ShSh, ed. M.: IP T.A. Alekseeva; 2019. (In Russ.)"},{"key":"key-10.17116\/neiro20248805130-25","doi-asserted-by":"publisher","DOI":"10.12740\/PP\/45368"},{"key":"key-10.17116\/neiro20248805130-26","unstructured":"Oleinik AA, Oleinik EA, Ivanov AYu, Ivanova NE. Long-term results after surgical treatment of multiple cerebral aneurysms with a history of subarachnoid hemorrhage. Russian Neurosurgical Journal named after Professor A.L. Polenov. 2018;10:185-186. (In Russ.)"},{"key":"key-10.17116\/neiro20248805130-27","unstructured":"Ermakov SV, Belokon OS, Kornev AP, Grishko EA, Ivanova NE, Karpov SM, Eliseev VV, Samochernykh KA. Results of surgical treatment of patients with severe aneurysmal subarachnoid hemorrhage. Russian Neurosurgical Journal named after Professor A.L. Polenov. 2023;15(3):30-39. (In Russ.)"}],"container-title":["Burdenko's Journal of Neurosurgery"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T07:07:55Z","timestamp":1745392075000},"score":1,"resource":{"primary":{"URL":"https:\/\/mediasphera.ru\/issues\/zhurnal-voprosy-nejrokhirurgii-imeni-n-n-burdenko\/2024\/5\/1004288172024051030"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":27,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10,18]]}},"alternative-id":["10.17116\/neiro20248805130"],"URL":"https:\/\/doi.org\/10.17116\/neiro20248805130","relation":{},"ISSN":["0042-8817"],"issn-type":[{"type":"print","value":"0042-8817"}],"subject":[],"published":{"date-parts":[[2024,4,23]]}}}