{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:22:59Z","timestamp":1747200179963,"version":"3.40.5"},"reference-count":10,"publisher":"Media Sphere Publishing House","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Burdenko's Journal of Neurosurgery"],"published-print":{"date-parts":[[2024,4,23]]},"abstract":"<jats:p>Prognosis of IDH (IDHwt) wild-type gliomas is worse compared to IDH-mutant tumors regardless of histological criteria for glioblastoma. However, there is still uncertainty regarding favorable course of disease and predictors of long-term survival in IDHwt gliomas. Objective. To study the metabolic characteristics of IDH1wt diffuse astrocytomas using 11C-methionine PET\/CT and prognostic significance of PET-associated parameters for disease-free survival. Material and methods. We analyzed 79 adults with IDH1wt diffuse gliomas. Quantitative analysis consisted of 11C-methionine accumulation index and metabolic tumor volume. Kaplan-Meier and Cox analyses were used to determine prognostic significance of histological findings and PET parameters. Results. Glioblastoma and astrocytoma grade 2 or 3 were diagnosed in 41% and 59% of patients, respectively. Accumulation index significantly differed between astrocytomas grade 2 and 3 (p=0.03). Significant predictors of disease-free survival were age, histological type of astrocytoma and tumor grade, contrast enhancement, PET-associated biomarkers (accumulation index and metabolic tumor volume) and compliance of metabolic pattern with glioblastoma syndrome (p&lt;0.05). Disease-free survival &gt;24 months was established for age &lt;41 years, maximum accumulation index &lt;1.64, tumor accumulation index &lt;1.39 and metabolic tumor volume &lt;13.44 cm3. In multivariate Cox analysis, independent predictors of disease-free survival were age and PET syndrome of glioblastoma. Conclusion. Diffuse IDH1wt gliomas are a heterogeneous group differing in metabolic characteristics and prognosis. PET\/CT with 11C-methionine may be effective for stratifying patients into groups with unfavorable and favorable prognosis, as well as assessment of advisability of in-depth searching for IDH1\/IDH2 mutation.<\/jats:p>","DOI":"10.17116\/neiro2024880516","type":"journal-article","created":{"date-parts":[[2024,10,18]],"date-time":"2024-10-18T15:00:41Z","timestamp":1729263641000},"page":"6","source":"Crossref","is-referenced-by-count":0,"title":["PET\/CT with 11C-methionine as a predictor of disease-free survival in patients with IDH1 wild type diffuse glioma"],"prefix":"10.17116","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0392-7576","authenticated-orcid":false,"given":"T.Yu.","family":"Skvortsova","sequence":"first","affiliation":[{"name":"Bekhtereva Institute of the Human Brain","place":["St. Petersburg, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9306-2101","authenticated-orcid":false,"given":"Zh.I.","family":"Savintseva","sequence":"additional","affiliation":[{"name":"Bekhtereva Institute of the Human Brain","place":["St. Petersburg, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3843-7967","authenticated-orcid":false,"given":"A.F.","family":"Gurchin","sequence":"additional","affiliation":[{"name":"Bekhtereva Institute of the Human Brain","place":["St. Petersburg, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9284-1119","authenticated-orcid":false,"given":"R.Yu.","family":"Seliverstov","sequence":"additional","affiliation":[{"name":"Bekhtereva Institute of the Human Brain","place":["St. Petersburg, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/neiro2024880516-1","doi-asserted-by":"crossref","unstructured":"Cohen A., Holmen S., Colman H. IDH1 and IDH2 mutations in gliomas. Current Neurology and Neuroscience Reports. 2013;13(4):345.  https:\/\/doi:10.1007\/s11910-013-0345-4","DOI":"10.1007\/s11910-013-0345-4"},{"key":"key-10.17116\/neiro2024880516-2","doi-asserted-by":"publisher","DOI":"10.1007\/s00401-018-1913-0"},{"key":"key-10.17116\/neiro2024880516-3","doi-asserted-by":"publisher","DOI":"10.1093\/neuonc\/noab106"},{"key":"key-10.17116\/neiro2024880516-4","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04337-0"},{"key":"key-10.17116\/neiro2024880516-5","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-019-04477-3"},{"key":"key-10.17116\/neiro2024880516-6","doi-asserted-by":"crossref","unstructured":"Gomzina NF, Kuznetsova OF. Preparation of [11C-methyl]-L-methionine in high enantiomeric purity by \u201con-line\u201d 11C-methylation. Bioorganicheskaya khimiya. 2011;37(2):216-222. (In Russ.)","DOI":"10.1134\/S1068162011020051"},{"key":"key-10.17116\/neiro2024880516-7","doi-asserted-by":"crossref","unstructured":"Skvortsova TYu, Savintseva ZhI, Zakhs DV, Tyurin RV, Gurchin AF, Kholyavin AI, Trofimova TN. Comparison of amino acid radiotracers L-[methyl-11C]methionine and O-2-[18F]fluoroethyl-L-tyrosine for PET\/CT imaging of cerebral gliomas. Luchevaya diagnostika i terapiya. 2021;1(12):49-58. (In Russ.)","DOI":"10.22328\/2079-5343-2021-12-1-49-58"},{"key":"key-10.17116\/neiro2024880516-8","doi-asserted-by":"publisher","DOI":"10.1111\/ene.13826"},{"key":"key-10.17116\/neiro2024880516-9","doi-asserted-by":"publisher","DOI":"10.3390\/cancers13133163"},{"key":"key-10.17116\/neiro2024880516-10","doi-asserted-by":"publisher","DOI":"10.1007\/s00259-020-04695-0"}],"container-title":["Burdenko's Journal of Neurosurgery"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T07:07:43Z","timestamp":1745392063000},"score":1,"resource":{"primary":{"URL":"https:\/\/mediasphera.ru\/issues\/zhurnal-voprosy-nejrokhirurgii-imeni-n-n-burdenko\/2024\/5\/1004288172024051006"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":10,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,10,18]]}},"alternative-id":["10.17116\/neiro2024880516"],"URL":"https:\/\/doi.org\/10.17116\/neiro2024880516","relation":{},"ISSN":["0042-8817"],"issn-type":[{"type":"print","value":"0042-8817"}],"subject":[],"published":{"date-parts":[[2024,4,23]]}}}