{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T17:20:20Z","timestamp":1786123220887,"version":"build-2736575974"},"reference-count":18,"publisher":"Media Sphere Publishing House","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Burdenko's Journal of Neurosurgery"],"published-print":{"date-parts":[[2026,8,7]]},"abstract":"<jats:p>Background. Schwannomas are benign (WHO Grade I) tumors of peripheral nerves arising from Schwann cells. Discrepancies between biological behavior and histological characteristics of tumor may exist. We consider it appropriate to describe such a case and compare it with literature data. Material and methods. A patient with subcutaneous schwannoma of the lower third of the right leg complicated by skin ulceration is presented. A review is devoted to data on atypical clinical course of schwannomas. Results and discussion. A 55-year-old man presented with tumor in the lower third of the right leg and skin ulceration 3.5\u00d73 cm. The tumor appeared 10 months ago and significantly enlarged. Open biopsy revealed WHO Grade 1 schwannoma. Atypical course of disease required an extended resection of tumor and simultaneous skin defect closure with split-thickness thigh skin flap. Two months after surgery, the wound healed via primary intention. There were no signs of tumor recurrence, and Karnofsky score was 100. Conclusion. Atypical course of cutaneous schwannoma with ulcers complicates accurate and timely diagnosis, as well as complicates patient management, selection of primary specialist and surgical approach. Benign tumor verified by biopsy and clinical manifestations typical for soft tissue cancer can require early surgical intervention based on oncological principles.<\/jats:p>","DOI":"10.17116\/neiro20269004167","type":"journal-article","created":{"date-parts":[[2026,8,7]],"date-time":"2026-08-07T14:08:33Z","timestamp":1786111713000},"page":"67","source":"Crossref","is-referenced-by-count":0,"title":["Atypical course of cutaneous schwannoma: a case report and literature review"],"prefix":"10.17116","volume":"90","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8807-3874","authenticated-orcid":false,"given":"A.G.","family":"Fedyakov","sequence":"first","affiliation":[{"name":"Botkin Hospital","place":["Moscow, Russia"]},{"name":"Russian Medical Academy of Continuous Professional Education","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3593-7034","authenticated-orcid":false,"given":"A.V.","family":"Gorozhanin","sequence":"additional","affiliation":[{"name":"Botkin Hospital","place":["Moscow, Russia"]},{"name":"Russian Medical Academy of Continuous Professional Education","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1297-1616","authenticated-orcid":false,"given":"Z.Kh.","family":"Plieva","sequence":"additional","affiliation":[{"name":"Russian Medical Academy of Continuous Professional Education","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8613-9609","authenticated-orcid":false,"given":"E.I.","family":"Zakurdaev","sequence":"additional","affiliation":[{"name":"Botkin Hospital","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8026-5919","authenticated-orcid":false,"given":"Yu.A.","family":"Kozlova","sequence":"additional","affiliation":[{"name":"Botkin Hospital","place":["Moscow, Russia"]},{"name":"Russian Medical Academy of Continuous Professional Education","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-3798-2998","authenticated-orcid":false,"given":"I.M.","family":"Silaev","sequence":"additional","affiliation":[{"name":"Botkin Hospital","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2339-2152","authenticated-orcid":false,"given":"M.S.","family":"Polichuk","sequence":"additional","affiliation":[{"name":"Botkin Hospital","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6743","reference":[{"key":"key-10.17116\/neiro20269004167-1","doi-asserted-by":"publisher","DOI":"10.17116\/neiro202387051104"},{"key":"key-10.17116\/neiro20269004167-2","doi-asserted-by":"publisher","DOI":"10.4132\/jptm.2023.07.13"},{"key":"key-10.17116\/neiro20269004167-3","doi-asserted-by":"publisher","DOI":"10.1177\/19714009251313510"},{"key":"key-10.17116\/neiro20269004167-4","doi-asserted-by":"publisher","DOI":"10.3390\/cancers15071930"},{"key":"key-10.17116\/neiro20269004167-5","doi-asserted-by":"publisher","DOI":"10.1007\/s13671-024-00429-9"},{"key":"key-10.17116\/neiro20269004167-6","doi-asserted-by":"publisher","DOI":"10.1097\/PAS.0000000000000589"},{"key":"key-10.17116\/neiro20269004167-7","doi-asserted-by":"publisher","DOI":"10.17816\/phf641606"},{"key":"key-10.17116\/neiro20269004167-8","unstructured":"Sarkomy myagkikh tkaney: klinicheskie rekomendatsii [Soft tissue sarcomas: clinical guidelines]. Moscow: Republican Center for Healthcare Development; 2025. (In Russ.)"},{"key":"key-10.17116\/neiro20269004167-9","doi-asserted-by":"publisher","DOI":"10.17116\/neiro20198303164"},{"key":"key-10.17116\/neiro20269004167-10","unstructured":"Vavrinchuk AS, Marochko AYu. Skin cancer: risk factors, epidemiology in Russia and worldwide. Modern Problems of Science and Education. 2015;6. (In Russ.)"},{"key":"key-10.17116\/neiro20269004167-11","doi-asserted-by":"publisher","DOI":"10.15386\/mpr-1708"},{"key":"key-10.17116\/neiro20269004167-12","unstructured":"Baranova IB, Slavnova EN, Petrov AN. Cytological diagnosis of schwannoma: three clinical observations. News of Clinical Cytology of Russia. 2023;2. 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