{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T22:11:00Z","timestamp":1792188660303,"version":"4.4.0"},"reference-count":28,"publisher":"Media Sphere Publishing House","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. Ann. Ophthal."],"published-print":{"date-parts":[[2023,4,17]]},"abstract":"<jats:p>In patients with glaucoma, the neuroplasticity of retinal cells, their axons and neuroglial elements is pathogenetically reduced, including due to a decrease in the concentration of neurotrophic factors. Coronavirus infections contribute to the damage processes, causing apoptosis of retinal and optic nerve cells. In this regard, the possibility of pharmacological stimulation of the production of these peptides through energy potentiation of the cell mitochondria function, reduction of oxidative stress severity and activation of interneuronal transduction system becomes relevant. Purpose. This study aimed to conduct a comprehensive diagnosis of the severity of oxidative stress, identify changes in the neuroplasticity and reparative ability of the retina in patients with primary open-angle glaucoma (POAG) who have recovered after a coronavirus infection, and are undergoing therapy with the complex drug Cytoflavin. Material and methods. The study included 40 patients (mean age 57.2\u00b13.6 years) with advanced POAG compensated by hypotensive agents; all of them recovered from moderate Covid-19 30 to 90 days prior to inclusion in the study. Twenty patients of the main group received therapy with the complex drug Cytoflavin, 20 other patients comprised the control group. In the comparison groups, the concentration of BDNF and CNTF in blood serum (SC) was determined by enzyme-linked immunosorbent assay (ELISA). Overall assessment of oxidative stress was done by high performance liquid chromatography. Studies of the functional activity of the retina were performed using the Tomey EP 1000 electroretinograph according to the standard method. Results and discussion. Retinal photosensitivity significantly improved in patients of the main group taking the complex drug Cytoflavin (mD mean after treatment increased from \u20137.34\u00b10.62 dB to \u20134.52\u00b10.12 dB (p&gt;0.001), PSD mean decreased from 6.23\u00b10.21dB to 4.27\u00b10.13 dB (p&gt;0.001)); the neural activity of the retina improved according to PERG (the amplitudes of the P50 and N95 components increased from 0.92\u00b10.04 \u00b5v to 1.65\u00b10.01 \u00b5v and from 1.83\u00b10.06 \u00b5v to 2.68\u00b10.01 \u00b5v, respectively (p&gt;0.001), the latency of the P50 and N95 components decreased from 53.40\u00b12.51 ms to 49.37\u00b12.22 ms and from 112.40\u00b15.23 ms to 107.4\u00b18.11ms, respectively (p&gt;0.001); the concentration of BDNF increased (from 18.65\u00b15.32 ng\/ml to 20.23\u00b14.05 ng\/ml (p&gt;0.001)) and the concentration of CNTF in the blood serum decreased (from 3.99\u00b10.37 pg\/ml to 1.85\u00b10.02pg\/ml (p&gt;0.001)), the severity of oxidative stress decreased (the indicator of oxidative stress decreased by 1.4 times after treatment p&gt;0.001) and the content of antioxidant protection indicators increased: the indicator of antioxidant protection of blood serum increased by 1.4 times, the concentration of superoxide dismutase \u2014 by 1.9 times (p&gt;0.001), glutathione peroxidase \u2014 by 1.4 times (p&gt;0.001), coenzyme Q10 \u2014 by 4.5 times (p&gt;0.001). Conclusion. The obtained data can be used to determine the risk of progression of glaucomatous optic neuropathy in patients with glaucoma who have had a coronavirus infection.<\/jats:p>","DOI":"10.17116\/oftalma202313902144","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T16:23:17Z","timestamp":1681748597000},"page":"44","source":"Crossref","is-referenced-by-count":3,"title":["Therapeutic possibilities of stimulating reparative neurogenesis in patients with glaucoma who have recovered from a coronavirus infection"],"prefix":"10.17116","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-3679-8619","authenticated-orcid":false,"given":"T.N.","family":"Malishevskaya","sequence":"first","affiliation":[{"name":"Helmholtz National Medical Research Center of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6922-0464","authenticated-orcid":false,"given":"S.Yu.","family":"Petrov","sequence":"additional","affiliation":[{"name":"Helmholtz National Medical Research Center of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1566-2299","authenticated-orcid":false,"given":"S.A.","family":"Petrov","sequence":"additional","affiliation":[{"name":"Federal Research Center Tyumen Scientific Center of Siberian Branch of the Russian Academy of Sciences","place":["Tyumen, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6835-3393","authenticated-orcid":false,"given":"A.S.","family":"Vlasova","sequence":"additional","affiliation":[{"name":"Federal Research Center Tyumen Scientific Center of Siberian Branch of the Russian Academy of Sciences","place":["Tyumen, Russia"]},{"name":"Regional Ophthalmology Clinic","place":["Tyumen, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5035-3128","authenticated-orcid":false,"given":"Yu.E.","family":"Filippova","sequence":"additional","affiliation":[{"name":"Federal Research Center Tyumen Scientific Center of Siberian Branch of the Russian Academy of Sciences","place":["Tyumen, Russia"]},{"name":"Regional Ophthalmology Clinic","place":["Tyumen, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8090-6034","authenticated-orcid":false,"given":"O.I.","family":"Markelova","sequence":"additional","affiliation":[{"name":"Helmholtz National Medical Research Center of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6743","reference":[{"key":"key-10.17116\/oftalma202313902144-1","unstructured":"Listings of WHO\u2019s response to COVID-19 (In Russ.). https:\/\/www.who.int\/ru\/news\/item\/29-06-2020-covidtimeline"},{"key":"key-10.17116\/oftalma202313902144-2","doi-asserted-by":"publisher","DOI":"10.15789\/2220-7619-HOI-1412"},{"key":"key-10.17116\/oftalma202313902144-3","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18052621"},{"key":"key-10.17116\/oftalma202313902144-4","unstructured":"Recommendations to support self-rehabilitation after illness caused by COVID-19. 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