{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T20:52:33Z","timestamp":1773867153590,"version":"3.50.1"},"reference-count":21,"publisher":"Media Sphere Publishing House","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. Ann. Ophthal."],"published-print":{"date-parts":[[2023,4,17]]},"abstract":"<jats:p>Currently there is no specific algorithm for treating rhegmatogenous retinal detachment complicated by macular hole. Purpose. The study analyzed the long-term outcomes of surgical treatment of rhegmatogenous retinal detachment (RRD) complicated by macular hole (MH) using platelet-rich plasma (PRP) and local staining of the internal limiting membrane (ILM). Material and methods. This prospective open-label study included 27 patients (15 females and 12 males) aged 57 to 65 (59.2\u00b17.2) years. In all studied cases, RRD complicated by MH was determined. The best corrected visual acuity (BCVA) before surgery was 0.05\u00b10.01 (from 0.02 to 0.08). The average MH diameter measured with OCT was 576.3\u00b1150.4 \u03bcm (409 \u03bcm to 944 \u03bcm). After vitrectomy, a perfluororganic compound (PFOC) was injected into the MH area in amount of 2\u20143 optic nerve head diameters to prevent the ingress of dye under the retina, then the internal limiting membrane (ILM) was stained and removed. After sequential PFOC\/air replacement, PRP was injected into the macular hole site. Results and discussion. An increase in BCVA from 0.05\u00b10.01 to 0.09\u00b10.03 was observed in the preoperative period one month after surgery, with a further increase to 0.35\u00b10.11 at the maximum follow-up time (two years). The MH was blocked and a glial scar was present in all cases according to OCT data. 1\u20142 years after the operation, all patients showed a favorable anatomical effect according to OCT data. According to computer microperimetry data, mean macular photosensitivity was 23.8\u00b11.3 dB two years after the surgery. Conclusions. This study shows a favorable anatomical and functional effect in patients with RRD and MH within a 2-year follow-up. A comparative study involving a larger cohort of patients is required to clarify the indications and contraindications for the use of the studied technique.<\/jats:p>","DOI":"10.17116\/oftalma20231390216","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T16:23:17Z","timestamp":1681748597000},"page":"6","source":"Crossref","is-referenced-by-count":4,"title":["Long-term outcomes of treating rhegmatogenous retinal detachment with macular hole using platelet-rich blood plasma"],"prefix":"10.17116","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5666-3493","authenticated-orcid":false,"given":"B.E.","family":"Malyugin","sequence":"first","affiliation":[{"name":"S.N. Fedorov National Medical Research Center \u201cMNTK \u201cEye Microsurgery\u201d","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0176-928X","authenticated-orcid":false,"given":"D.O.","family":"Shkvorchenko","sequence":"additional","affiliation":[{"name":"S.N. Fedorov National Medical Research Center \u201cMNTK \u201cEye Microsurgery\u201d","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3293-5487","authenticated-orcid":false,"given":"A.G.","family":"Khurdaeva","sequence":"additional","affiliation":[{"name":"S.N. Fedorov National Medical Research Center \u201cMNTK \u201cEye Microsurgery\u201d","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/oftalma20231390216-1","doi-asserted-by":"publisher","DOI":"10.18008\/1816-5095-2015-1-24-32"},{"key":"key-10.17116\/oftalma20231390216-2","doi-asserted-by":"publisher","DOI":"10.1016\/j.oftal.2011.10.013"},{"key":"key-10.17116\/oftalma20231390216-3","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002155"},{"key":"key-10.17116\/oftalma20231390216-4","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214674"},{"key":"key-10.17116\/oftalma20231390216-5","doi-asserted-by":"publisher","DOI":"10.18008\/1816-5095-2017-1-27-31"},{"key":"key-10.17116\/oftalma20231390216-6","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2012-302330"},{"key":"key-10.17116\/oftalma20231390216-7","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2020.05.030"},{"key":"key-10.17116\/oftalma20231390216-8","unstructured":"Zakharov VD, Shkvorchenko DO, Kakunina SA, Norman KS, Fozilova F.F. The efficiency of peeling of the inner limiting membrane on the background of a silicone oil tamponade in rhegmatogenous retinal detachment. Tavricheskiy Mediko-Biologicheskiy Vestnik. 2018;21(4):23-27. (In Russ.)"},{"key":"key-10.17116\/oftalma20231390216-9","doi-asserted-by":"publisher","DOI":"10.18008\/1816-5095-2019-4-449-453"},{"key":"key-10.17116\/oftalma20231390216-10","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31826b671c"},{"key":"key-10.17116\/oftalma20231390216-11","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-015-0154-4"},{"key":"key-10.17116\/oftalma20231390216-12","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001307"},{"key":"key-10.17116\/oftalma20231390216-13","doi-asserted-by":"publisher","DOI":"10.1111\/j.1442-9071.2010.02333.x"},{"key":"key-10.17116\/oftalma20231390216-14","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-016-0266-5"},{"key":"key-10.17116\/oftalma20231390216-15","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31827b6422"},{"key":"key-10.17116\/oftalma20231390216-16","doi-asserted-by":"publisher","DOI":"10.1177\/1120672120953314"},{"key":"key-10.17116\/oftalma20231390216-17","doi-asserted-by":"publisher","DOI":"10.29413\/ABS.2019-4.4.8"},{"key":"key-10.17116\/oftalma20231390216-18","unstructured":"Zaharov VD, Shkvorchenko DO, Krupina EA, Kakunina SA, Norman KS, Khurdaeva AG, Yukhananova AV. Surgical treatment of regmatogenous retinal detachment complicated by macular hole using platelet-rich blood plasma and local staining. Saratov Journal of Medical Scientific Research = Saratovskiy nauchno-meditsinskiy zhurnal. 2018;14(4):867-870. (In Russ.)"},{"key":"key-10.17116\/oftalma20231390216-19","doi-asserted-by":"publisher","DOI":"10.1097\/00006982-200601000-00005"},{"key":"key-10.17116\/oftalma20231390216-20","unstructured":"Rouhette H, Cauchi O, Zur C, Gastaud P. D\u00e9collement de r\u00e9tine par troumaculaire du myope fort. Evaluation des crit\u00e8res pronostiques [Retinal detachment due to macular holes in highly myopic eyes. Prognosticfactors]. 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