{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,6]],"date-time":"2025-10-06T18:53:27Z","timestamp":1759776807013,"version":"3.40.5"},"reference-count":15,"publisher":"Media Sphere Publishing House","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. Ann. Ophthal."],"published-print":{"date-parts":[[2023,4,17]]},"abstract":"<jats:p>Neuromyelitis optica spectrum disorders (NMOSD) comprise a group of autoimmune inflammatory demyelinating diseases of the central nervous system that manifest as optic neuritis and transverse myelitis. Its manifestation in the form of optic neuritis makes early diagnosis difficult because neuroimaging of the spinal cord is not a part of the routine examination algorithm for such patients. This article presents the results of a comprehensive ophthalmological examination of 4 patients (8 eyes) diagnosed with NMSOD. Optic neuritis was the disease debut in 3 patients and had 1\u20142 relapses, in all cases partial optic atrophy with moderate to severe loss of visual function occurred. The clinical picture was characterized by a pronounced heterogeneity in terms of both ophthalmological symptoms, and accession of neurological disorders. Treatment of NMOSD requires differential diagnosis with multiple sclerosis, which depends on the awareness of specialists and the inclusion of antibody titers to aquaporin-4 and myelin oligodendrocyte glycoprotein into the examination algorithm of patients with optical neuritis.<\/jats:p>","DOI":"10.17116\/oftalma202313902161","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T16:23:17Z","timestamp":1681748597000},"page":"61","source":"Crossref","is-referenced-by-count":2,"title":["Clinical phenotypes of optic nerve damage in patients with neuromyelitis optica spectrum disorder"],"prefix":"10.17116","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7472-4883","authenticated-orcid":false,"given":"S.N.","family":"Svetozarskiy","sequence":"first","affiliation":[{"name":"Volga Regional Medical Center of the Federal Medical-Biological Agency","place":["Nizhny Novgorod, Russia"]},{"name":"Privolzhsky Research Medical University","place":["Nizhny Novgorod, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0926-7724","authenticated-orcid":false,"given":"S.V.","family":"Kopishinskaya","sequence":"additional","affiliation":[{"name":"Kirov State Medical University","place":["Kirov, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4595-2614","authenticated-orcid":false,"given":"E.A.","family":"Ruina","sequence":"additional","affiliation":[{"name":"Privolzhsky Research Medical University","place":["Nizhny Novgorod, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8972-9150","authenticated-orcid":false,"given":"E.A.","family":"Antipenko","sequence":"additional","affiliation":[{"name":"Privolzhsky Research Medical University","place":["Nizhny Novgorod, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/oftalma202313902161-1","doi-asserted-by":"publisher","DOI":"10.7861\/clinmedicine.19-2-169"},{"key":"key-10.17116\/oftalma202313902161-2","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2019.08.001"},{"key":"key-10.17116\/oftalma202313902161-3","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0718-0"},{"key":"key-10.17116\/oftalma202313902161-4","doi-asserted-by":"publisher","DOI":"10.1177\/1352458519893093"},{"key":"key-10.17116\/oftalma202313902161-5","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-020-01334-8"},{"key":"key-10.17116\/oftalma202313902161-6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jneuroim.2016.11.010"},{"key":"key-10.17116\/oftalma202313902161-7","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2018-312231"},{"key":"key-10.17116\/oftalma202313902161-8","doi-asserted-by":"publisher","DOI":"10.1186\/s12974-016-0746-9"},{"key":"key-10.17116\/oftalma202313902161-9","doi-asserted-by":"publisher","DOI":"10.1177\/2055217318791196"},{"key":"key-10.17116\/oftalma202313902161-10","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-018-0902-3"},{"key":"key-10.17116\/oftalma202313902161-11","doi-asserted-by":"publisher","DOI":"10.3390\/ijms21145021"},{"key":"key-10.17116\/oftalma202313902161-12","doi-asserted-by":"publisher","DOI":"10.1093\/brain\/awz054"},{"key":"key-10.17116\/oftalma202313902161-13","doi-asserted-by":"publisher","DOI":"10.3390\/ph14010037"},{"key":"key-10.17116\/oftalma202313902161-14","doi-asserted-by":"publisher","DOI":"10.1177\/1352458511421185"},{"key":"key-10.17116\/oftalma202313902161-15","doi-asserted-by":"publisher","DOI":"10.1007\/s00415-015-7991-1"}],"container-title":["Russian Annals of Ophthalmology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T13:48:00Z","timestamp":1745502480000},"score":1,"resource":{"primary":{"URL":"https:\/\/mediasphera.ru\/issues\/vestnik-oftalmologii\/2023\/2\/10042465X2023021061"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,17]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,4,17]]}},"alternative-id":["10.17116\/oftalma202313902161"],"URL":"https:\/\/doi.org\/10.17116\/oftalma202313902161","relation":{},"ISSN":["0042-465X"],"issn-type":[{"type":"print","value":"0042-465X"}],"subject":[],"published":{"date-parts":[[2023,4,17]]}}}