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Numerous clinical studies have shown that instillations of cyclosporine into the conjunctival cavity contribute to an increase in total tear production, as well as recovery of the density of goblet cells in the conjunctiva of DES patients. The positive effect of cyclosporine A instillations has been convincingly demonstrated in the complex therapy of patients with vernal and atopic corneal conjunctivitis, Thygeson\u2019s superficial punctate keratitis, autoimmune keratitis, meibomian gland dysfunction, etc. However, one significant problem associated with cyclosporine A instillations is the irritating effect of the drug. That prompted the development of a drug that is safe and tolerable during instillations into the conjunctival cavity \u2014 preservative-free 0.1% cyclosporine A labelled Ikervis (Santen, Japan). The drug carrier is artificial tear Cationorm (Santen), which has an advantage of stabilizing the tear film and protecting the ocular surface from the irritating effect of cyclosporine. According to numerous clinical studies, Ikervis instillations can improve the effectiveness of complex therapy in patients with DES (especially secondary to Sj\u00f6gren syndrome, Stevens-Johnson syndrome, graft-versus-host disease), with allergic diseases of the cornea and conjunctiva (spring, atopic corneal conjunctivitis), with corneal transplant disease, and other similar conditions. The high efficacy and safety of Ikervis constitute the reason to recommend it for wide clinical use.<\/jats:p>","DOI":"10.17116\/oftalma202313902195","type":"journal-article","created":{"date-parts":[[2023,4,17]],"date-time":"2023-04-17T16:23:17Z","timestamp":1681748597000},"page":"95","source":"Crossref","is-referenced-by-count":5,"title":["Modern possibilities of pathogenetically oriented therapy for dry eye syndrome"],"prefix":"10.17116","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7361-0270","authenticated-orcid":false,"given":"V.V.","family":"Brzheskiy","sequence":"first","affiliation":[{"name":"Saint Petersburg State Pediatric Medical University","place":["Saint Petersburg, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/oftalma202313902195-1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.006"},{"key":"key-10.17116\/oftalma202313902195-2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2021.11.004"},{"key":"key-10.17116\/oftalma202313902195-3","doi-asserted-by":"publisher","DOI":"10.21516\/2072-0076-2022-15-2-154-159"},{"key":"key-10.17116\/oftalma202313902195-4","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000002622"},{"key":"key-10.17116\/oftalma202313902195-5","doi-asserted-by":"publisher","DOI":"10.17116\/oftalma2022138061123"},{"key":"key-10.17116\/oftalma202313902195-6","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.011"},{"key":"key-10.17116\/oftalma202313902195-7","unstructured":"Brzheskiy VV, Egorova GB, Egorov EA. 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