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An in vitro culture of endotheliocytes showed a correlation between the degree of damaging effects of antiglaucoma drugs of various groups and the content of the preservative benzalkonium chloride in their composition. Corneal keratocytes were used to create a cell sheet reflecting the main structural features of the stroma and suitable for biomechanical tests. The antifibrotic activity of the drugs was tested on the culture of fibroblasts from the nasolacrimal duct. The conducted studies demonstrate that cell cultures can be used as an informative model object for researching the pathogenesis of ophthalmic diseases and for testing drugs.<\/jats:p>","DOI":"10.17116\/oftalma2023139032128","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T08:49:59Z","timestamp":1683276599000},"page":"128","source":"Crossref","is-referenced-by-count":0,"special_numbering":"Vyp. 2","title":["Cell cultures \u2014 model object for experimental studies in ophthalmology"],"prefix":"10.17116","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8258-6011","authenticated-orcid":false,"given":"A.M.","family":"Subbot","sequence":"first","affiliation":[{"name":"Krasnov Research Institute of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7198-4498","authenticated-orcid":false,"given":"N.V.","family":"Fisenko","sequence":"additional","affiliation":[{"name":"Krasnov Research Institute of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5778-4123","authenticated-orcid":false,"given":"V.V.","family":"Averich","sequence":"additional","affiliation":[{"name":"Krasnov Research Institute of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5757-6719","authenticated-orcid":false,"given":"L.S.","family":"Pateyuk","sequence":"additional","affiliation":[{"name":"Krasnov Research Institute of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0771-8934","authenticated-orcid":false,"given":"A.V.","family":"Kobzeva","sequence":"additional","affiliation":[{"name":"Krasnov Research Institute of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9875-6217","authenticated-orcid":false,"given":"E.L.","family":"Atkova","sequence":"additional","affiliation":[{"name":"Krasnov Research Institute of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/oftalma2023139032128-1","unstructured":"Erichev VP, Ambartsumyan KH. The preservatives and secondary dry eye syndrome at topical long-term open-angle glaucoma therapy. Glaukoma. 2011;2:59-66. (In Russ.)"},{"key":"key-10.17116\/oftalma2023139032128-2","doi-asserted-by":"publisher","DOI":"10.30906\/0869-2092-2019-82-7-33-37"},{"key":"key-10.17116\/oftalma2023139032128-3","doi-asserted-by":"publisher","DOI":"10.23868\/202104010"},{"key":"key-10.17116\/oftalma2023139032128-4","doi-asserted-by":"publisher","DOI":"10.17816\/OV62857"},{"key":"key-10.17116\/oftalma2023139032128-5","unstructured":"Subbot AM, Fisenko NV. Izuchenie biosovmestimosti s kletkami limba rogovitsy cheloveka matriksov na osnove kollagena, primenyayushchikhsya v antiglaukomnoj khirurgii. Genes & Cells = Geny i Kletki. 2019;14(4-1):226. 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