{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:23:25Z","timestamp":1747200205412,"version":"3.40.5"},"reference-count":52,"publisher":"Media Sphere Publishing House","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. Ann. Ophthal."],"published-print":{"date-parts":[[2023,8,28]]},"abstract":"<jats:p>Application of new materials and methods in the diagnosis and treatment of eye diseases is one of the promising research areas in modern ophthalmology. Significant progress has been made in understanding the pathogenesis, diagnosis and treatment of eye diseases using nanotechnologies and nanomaterials. This paper presents the main achievements and results of original research on this issue. It has been shown that nanoparticles are able to overcome biological barriers, deliver drugs to the target site, and provide the required drug release rate. Modern nanotechnological approaches in tissue engineering are also being actively introduced into ophthalmology, making it possible to create nanoframeworks for growing three-dimensional cellular structures, including arrays of pigment epithelium cells and retinal ganglion cells for the treatment of retinal damage caused by degenerative diseases, injuries and infections.<\/jats:p>","DOI":"10.17116\/oftalma2023139041107","type":"journal-article","created":{"date-parts":[[2023,8,28]],"date-time":"2023-08-28T11:12:29Z","timestamp":1693221149000},"page":"107","source":"Crossref","is-referenced-by-count":1,"title":["Nanotechnologies in ophthalmology"],"prefix":"10.17116","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8699-9112","authenticated-orcid":false,"given":"A.A.","family":"Gusev","sequence":"first","affiliation":[{"name":"Tambov State University named after G.R. Derzhavin","place":["Tambov, Russia"]},{"name":"National University of Science and Technology (MISIS)","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8590-2529","authenticated-orcid":false,"given":"O.V.","family":"Zakharova","sequence":"additional","affiliation":[{"name":"Tambov State University named after G.R. Derzhavin","place":["Tambov, Russia"]},{"name":"National University of Science and Technology (MISIS)","place":["Moscow, Russia"]},{"name":"Plekhanov Russian University of Economics","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.A.","family":"Vasyukova","sequence":"additional","affiliation":[{"name":"Tambov State University named after G.R. Derzhavin","place":["Tambov, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8658-4005","authenticated-orcid":false,"given":"R.E.","family":"Osmanov","sequence":"additional","affiliation":[{"name":"Tambov branch of S.N. Fedorov National Medical Research Center \u201cMNTK \u201cEye Microsurgery\u201d","place":["Tambov, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3038-9075","authenticated-orcid":false,"given":"Ya.M.","family":"Al-Makhdar","sequence":"additional","affiliation":[{"name":"Krasnov Research Institute of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/oftalma2023139041107-1","unstructured":"Blindness and ocular disorders. World Health Organization 2021. Accessed November 11, 2021. (In Russ.). https:\/\/www.who.int\/ru\/news-room\/fact-sheets\/detail\/blindness-and-visual-impairment"},{"key":"key-10.17116\/oftalma2023139041107-2","doi-asserted-by":"publisher","DOI":"10.1016\/j.apsb.2016.09.001"},{"key":"key-10.17116\/oftalma2023139041107-3","doi-asserted-by":"publisher","DOI":"10.1016\/j.bbrc.2020.08.046"},{"key":"key-10.17116\/oftalma2023139041107-4","doi-asserted-by":"publisher","DOI":"10.18240\/ijo.2018.06.23"},{"key":"key-10.17116\/oftalma2023139041107-5","doi-asserted-by":"publisher","DOI":"10.3390\/molecules24203805"},{"key":"key-10.17116\/oftalma2023139041107-6","doi-asserted-by":"publisher","DOI":"10.1007\/s00347-017-0596-6"},{"key":"key-10.17116\/oftalma2023139041107-7","doi-asserted-by":"publisher","DOI":"10.1158\/1078-0432.CCR-07-1441"},{"key":"key-10.17116\/oftalma2023139041107-8","doi-asserted-by":"publisher","DOI":"10.3390\/polym12071519"},{"key":"key-10.17116\/oftalma2023139041107-9","doi-asserted-by":"publisher","DOI":"10.1016\/j.jddst.2019.101389"},{"key":"key-10.17116\/oftalma2023139041107-10","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181bd9eee"},{"key":"key-10.17116\/oftalma2023139041107-11","doi-asserted-by":"publisher","DOI":"10.3390\/md15120370"},{"key":"key-10.17116\/oftalma2023139041107-12","doi-asserted-by":"publisher","DOI":"10.1007\/s10096-015-2344-7"},{"key":"key-10.17116\/oftalma2023139041107-13","doi-asserted-by":"publisher","DOI":"10.3109\/10717544.2014.942811"},{"key":"key-10.17116\/oftalma2023139041107-14","doi-asserted-by":"publisher","DOI":"10.3390\/pharmaceutics10040197"},{"key":"key-10.17116\/oftalma2023139041107-15","doi-asserted-by":"publisher","DOI":"10.2147\/IJN.S214727"},{"key":"key-10.17116\/oftalma2023139041107-16","doi-asserted-by":"publisher","DOI":"10.1080\/17425247.2016.1201059"},{"key":"key-10.17116\/oftalma2023139041107-17","doi-asserted-by":"publisher","DOI":"10.1016\/j.jsps.2013.07.003"},{"key":"key-10.17116\/oftalma2023139041107-18","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.09-4373"},{"key":"key-10.17116\/oftalma2023139041107-19","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S91730"},{"key":"key-10.17116\/oftalma2023139041107-20","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2019.10.006"},{"key":"key-10.17116\/oftalma2023139041107-21","doi-asserted-by":"publisher","DOI":"10.3390\/ijms18092013"},{"key":"key-10.17116\/oftalma2023139041107-22","doi-asserted-by":"publisher","DOI":"10.1080\/00914037.2017.1362639"},{"key":"key-10.17116\/oftalma2023139041107-23","doi-asserted-by":"publisher","DOI":"10.1089\/jop.2015.0157"},{"key":"key-10.17116\/oftalma2023139041107-24","doi-asserted-by":"publisher","DOI":"10.1021\/acs.biomac.5b00129"},{"key":"key-10.17116\/oftalma2023139041107-25","doi-asserted-by":"publisher","DOI":"10.1007\/s40778-015-0014-4"},{"key":"key-10.17116\/oftalma2023139041107-26","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejps.2015.03.003"},{"key":"key-10.17116\/oftalma2023139041107-27","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12833"},{"key":"key-10.17116\/oftalma2023139041107-28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0143669"},{"key":"key-10.17116\/oftalma2023139041107-29","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2014.08.040"},{"key":"key-10.17116\/oftalma2023139041107-30","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEA.2015.0373"},{"key":"key-10.17116\/oftalma2023139041107-31","doi-asserted-by":"publisher","DOI":"10.1177\/2041731417720841"},{"key":"key-10.17116\/oftalma2023139041107-32","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2013.07.029"},{"key":"key-10.17116\/oftalma2023139041107-33","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2006.11.023"},{"key":"key-10.17116\/oftalma2023139041107-34","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2015.02.005"},{"key":"key-10.17116\/oftalma2023139041107-35","doi-asserted-by":"publisher","DOI":"10.3390\/ma7043106"},{"key":"key-10.17116\/oftalma2023139041107-36","doi-asserted-by":"publisher","DOI":"10.1016\/j.addr.2007.03.012"},{"key":"key-10.17116\/oftalma2023139041107-37","doi-asserted-by":"publisher","DOI":"10.1016\/j.biomaterials.2010.12.041"},{"key":"key-10.17116\/oftalma2023139041107-38","doi-asserted-by":"publisher","DOI":"10.3390\/jfb6010077"},{"key":"key-10.17116\/oftalma2023139041107-39","doi-asserted-by":"publisher","DOI":"10.1016\/j.actbio.2017.02.035"},{"key":"key-10.17116\/oftalma2023139041107-40","doi-asserted-by":"publisher","DOI":"10.1007\/s11033-012-2360-y"},{"key":"key-10.17116\/oftalma2023139041107-41","doi-asserted-by":"publisher","DOI":"10.1039\/d0bm01063d"},{"key":"key-10.17116\/oftalma2023139041107-42","doi-asserted-by":"crossref","unstructured":"Nguyen VP, Li Y, Qian W, Liu B, Tian C, Zhang W, et al. Contrast agent enhanced multimodal photoacoustic microscopy and optical coherence tomography for imaging of rabbit choroidal and retinal vessels in vivo. Sci Rep. 2019;9(1):1-17","DOI":"10.1038\/s41598-019-42324-5"},{"key":"key-10.17116\/oftalma2023139041107-43","doi-asserted-by":"publisher","DOI":"10.1038\/s41467-020-20276-z"},{"key":"key-10.17116\/oftalma2023139041107-44","doi-asserted-by":"publisher","DOI":"10.2217\/nnm-2018-0299"},{"key":"key-10.17116\/oftalma2023139041107-45","doi-asserted-by":"publisher","DOI":"10.7150\/thno.32546"},{"key":"key-10.17116\/oftalma2023139041107-46","doi-asserted-by":"publisher","DOI":"10.3390\/ijms12118288"},{"key":"key-10.17116\/oftalma2023139041107-47","doi-asserted-by":"crossref","unstructured":"S\u00f6derstjerna E, Patrik Bauer P, Cedervall T, Abdshill H, Johansson F, Johansson UE. Silver and Gold Nanoparticles Exposure to In Vitro Cultured Retina \u2014 Studies on Nanoparticle Internalization, Apoptosis, Oxidative Stress, Glial- and Microglial Activity. PLoS One. 2014;9(8):e105359","DOI":"10.1371\/journal.pone.0105359"},{"key":"key-10.17116\/oftalma2023139041107-48","doi-asserted-by":"publisher","DOI":"10.20538\/1682-0363-2008-2-70-78"},{"key":"key-10.17116\/oftalma2023139041107-49","doi-asserted-by":"crossref","unstructured":"Robinson DB, Persson HHJ, Zeng H. et al. DNA-Functionalized MFe2O4 (M=Fe, Co, or Mn) Nanoparticles and Their Hybridization to DNA-Functionalized Surfaces. Langmuir. 2005;21:3096-3103","DOI":"10.1021\/la047206o"},{"key":"key-10.17116\/oftalma2023139041107-50","doi-asserted-by":"crossref","unstructured":"Fortin-Ripoche J-P, Martina M-S, Gazeau F, et al. Magnetic targeting of magnetolipoaomes to solid tumors with MR imaging monitoring in mice: feasibility. Radiology. 2006;239(2):415-424","DOI":"10.1148\/radiol.2392042110"},{"key":"key-10.17116\/oftalma2023139041107-51","doi-asserted-by":"publisher","DOI":"10.20538\/1682-0363-2014-6-33-40"},{"key":"key-10.17116\/oftalma2023139041107-52","doi-asserted-by":"publisher","DOI":"10.3390\/molecules25143159"}],"container-title":["Russian Annals of Ophthalmology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T13:48:40Z","timestamp":1745502520000},"score":1,"resource":{"primary":{"URL":"https:\/\/mediasphera.ru\/issues\/vestnik-oftalmologii\/2023\/4\/10042465X2023041107"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,8,28]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2023,8,28]]}},"alternative-id":["10.17116\/oftalma2023139041107"],"URL":"https:\/\/doi.org\/10.17116\/oftalma2023139041107","relation":{},"ISSN":["0042-465X"],"issn-type":[{"type":"print","value":"0042-465X"}],"subject":[],"published":{"date-parts":[[2023,8,28]]}}}