{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:23:26Z","timestamp":1747200206856,"version":"3.40.5"},"reference-count":19,"publisher":"Media Sphere Publishing House","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. Ann. Ophthal."],"published-print":{"date-parts":[[2023,11,9]]},"abstract":"<jats:p>Familial exudative vitreoretinopathy (FEVR) is a rare hereditary disease characterized by pathological retinal vascularization with a progressive and variable course. The mechanisms of disease progression remain unclear. One substance that plays an important role in the pathogenesis of retinal vascular diseases is endothelin (ET). It was found that tissue hypoxia enhances the expression of the gene encoding ET-1, and ET-1 can be locally produced in the eye. Purpose. The study evaluates the possible role of endothelin-1 in the pathogenesis of FEVR. Material and methods. The study included 85 patients with FEVR aged from 1 months to 17 years who were examined in Helmholtz National Medical Research Center of Eye Diseases. The concentration of ET-1 was evaluated in 19 patients with FEVR in the blood serum (n=17), lacrimal fluid (n=18) and 16 patients from the control group. Results. The median of ET-1 in the lacrimal fluid in patients with FEVR was 13.74 pg\/mL, respectively, which exceeded the same indicator of the control group 4.66 pg\/mL by 2.5 times (p&lt;0.001). The median of ET-1 in the blood serum exceeded the control group by 2.4 times (21.61 pg\/mL and 9.21 pg\/mL, respectively, p&lt;0.001). Conclusions. An increase in the concentration of ET-1 in the lacrimal fluid and blood serum of patients with FEVR in comparison with the control group indicates its involvement in the pathogenesis of the disease.<\/jats:p>","DOI":"10.17116\/oftalma202313905114","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T10:18:18Z","timestamp":1699525098000},"page":"14","source":"Crossref","is-referenced-by-count":0,"title":["The role of endothelin-1 in the pathogenesis of familial exudative vitreoretinopathy"],"prefix":"10.17116","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4857-0374","authenticated-orcid":false,"given":"L.A.","family":"Katargina","sequence":"first","affiliation":[{"name":"Helmholtz National Medical Research Center of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7856-8005","authenticated-orcid":false,"given":"N.B.","family":"Chesnokova","sequence":"additional","affiliation":[{"name":"Helmholtz National Medical Research Center of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3735-6249","authenticated-orcid":false,"given":"E.V.","family":"Denisova","sequence":"additional","affiliation":[{"name":"Helmholtz National Medical Research Center of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5306-2534","authenticated-orcid":false,"given":"E.A.","family":"Geraskina","sequence":"additional","affiliation":[{"name":"Helmholtz National Medical Research Center of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8032-4248","authenticated-orcid":false,"given":"T.A.","family":"Pavlenko","sequence":"additional","affiliation":[{"name":"Helmholtz National Medical Research Center of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7557-4955","authenticated-orcid":false,"given":"O.V.","family":"Beznos","sequence":"additional","affiliation":[{"name":"Helmholtz National Medical Research Center of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7787-8581","authenticated-orcid":false,"given":"O.A.","family":"Lisovskaja","sequence":"additional","affiliation":[{"name":"Helmholtz National Medical Research Center of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/oftalma202313905114-1","doi-asserted-by":"crossref","unstructured":"Criswick V, Schepens CL. 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