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The study group included 197 patients aged 44 to 90 years (98 \u2014 patients with POAG, 99 \u2014 the control group), who were treated in the Republican Clinical Ophthalmological Hospital of the Ministry of Health of the Republic of Tatarstan named after Prof. E.V. Adamyuk. Results. Age, family history of the disease, presence of type 2 diabetes mellitus, arterial hypertension were revealed to be associated with an increased risk of POAG development. The polymorphisms of matrix metalloproteinase MMP9 and vitamin D receptor (VDR) genes were shown to influence the development of POAG. The prognostic model considering these factors had high sensitivity and specificity (72.0% and 82.6% respectively). Conclusion. The prognostic model based on environmental and genetic factors is important for assessing the risk of POAG and early detection of the disease.<\/jats:p>","DOI":"10.17116\/oftalma202313905174","type":"journal-article","created":{"date-parts":[[2023,11,9]],"date-time":"2023-11-09T10:18:18Z","timestamp":1699525098000},"page":"74","source":"Crossref","is-referenced-by-count":1,"title":["Assessment of environmental and genetic risk factors for the development of primary open-angle glaucoma"],"prefix":"10.17116","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0863-7762","authenticated-orcid":false,"given":"A.N.","family":"Samoylov","sequence":"first","affiliation":[{"name":"Kazan State Medical University","place":["Kazan, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9950-8992","authenticated-orcid":false,"given":"D.Yu.","family":"Plotnikov","sequence":"additional","affiliation":[{"name":"Kazan State Medical University","place":["Kazan, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7139-4033","authenticated-orcid":false,"given":"P.A.","family":"Tumanova","sequence":"additional","affiliation":[{"name":"Kazan State Medical University","place":["Kazan, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/oftalma202313905174-1","doi-asserted-by":"publisher","DOI":"10.32364\/2311-7729-2022-22-1-3-10"},{"key":"key-10.17116\/oftalma202313905174-2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2014.05.013"},{"key":"key-10.17116\/oftalma202313905174-3","doi-asserted-by":"publisher","DOI":"10.17116\/oftalma202013603179"},{"key":"key-10.17116\/oftalma202313905174-4","unstructured":"Tikunova EV, Churnosov MI. 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