{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:46:20Z","timestamp":1773013580662,"version":"3.50.1"},"reference-count":20,"publisher":"Media Sphere Publishing House","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. Ann. Ophthal."],"published-print":{"date-parts":[[2024,4,23]]},"abstract":"<jats:p>In recent years, among artificial tear preparations that have additional metabolic properties, in addition to moisturizing the ocular surface, there has been a drug Optinol Soft Recovery (LLC JADRAN). In addition to 0.15% sodium hyaluronate, it contains 2% dexpanthenol, which stimulates reparative regeneration of the corneal epithelium, in particular in patients with dry eye syndrome (DES). Purpose. This study evaluates the clinical efficacy of the drug Optinol Soft Recovery in the treatment of patients with DES accompanied by xerotic changes in the corneal epithelium. Material and methods. The study included 82 patients (15 children and 65 adults) with moderate and severe DES accompanied by the following corneal pathology: filamentous keratitis (20 patients, 33 eyes), persistent corneal erosion (28 patients, 49 eyes) and punctate keratopathy (34 patients, 68 eyes). Results. All patients receiving fourfold instillations of the studied drug were observed already during the first 7 days to have increased stability of the tear film and decreased severity of staining of the cornea and conjunctiva with vital dyes (0.1% sodium fluorescein and 3% lissamine green, respectively). Further, as the patients were transferred to an individual instillation regimen, a progressive decrease in the Ocular Surface Disease Index (OSDI), an increase in corneal sensitivity and tear meniscus index were also recorded. The differences in most parameters of the course of xerosis compared to the initial ones were statistically significant starting from day 10\u201420 of therapy, depending on the initial severity of corneal xerosis (p&lt;0.05\u20140.001). Conclusion. Patients with moderate DES complicated by punctate keratopathy were the most susceptible to therapy with the drug Optinol Soft Recovery, while patients with filamentous keratitis secondary to a severe clinical form of DES were the least susceptible.<\/jats:p>","DOI":"10.17116\/oftalma202414001158","type":"journal-article","created":{"date-parts":[[2024,3,7]],"date-time":"2024-03-07T10:05:28Z","timestamp":1709805928000},"page":"58","source":"Crossref","is-referenced-by-count":3,"title":["New possibilities for reparative therapy of dry eye syndrome"],"prefix":"10.17116","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-7361-0270","authenticated-orcid":false,"given":"V.V.","family":"Brzheskiy","sequence":"first","affiliation":[{"name":"Saint Petersburg State Pediatric Medical University","place":["Saint Petersburg, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1799-211X","authenticated-orcid":false,"given":"E.A.","family":"Drozdova","sequence":"additional","affiliation":[{"name":"South-Ural State Medical University","place":["Chelyabinsk, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3999-7173","authenticated-orcid":false,"given":"V.A.","family":"Bobryshev","sequence":"additional","affiliation":[{"name":"Saint Petersburg State Pediatric Medical University","place":["Saint Petersburg, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3935-6146","authenticated-orcid":false,"given":"E.V.","family":"Berdnikova","sequence":"additional","affiliation":[{"name":"South-Ural State Medical University","place":["Chelyabinsk, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2570-2784","authenticated-orcid":false,"given":"S.Yu.","family":"Golubev","sequence":"additional","affiliation":[{"name":"Institute of Biomedical Problems, Russian Academy of Sciences","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/oftalma202414001158-1","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.05.006"},{"key":"key-10.17116\/oftalma202414001158-2","unstructured":"Brzheskiy VV, Egorova GB, Egorov EA. Sindrom \u00absukhogo glaza\u00bb i zabolevaniya glaznoy poverkhnosti: klinika, diagnostika, lecheniye [Dry eye syndrome and ocular surface diseases: clinic, diagnosis, treatment]. M.: GEOTAR-Media; 2016. (In Russ.). https:\/\/www.rosmedlib.ru\/book\/ISBN9785970437797.html"},{"key":"key-10.17116\/oftalma202414001158-3","doi-asserted-by":"publisher","DOI":"10.21516\/2072-0076-2022-15-2-154-159"},{"key":"key-10.17116\/oftalma202414001158-4","doi-asserted-by":"publisher","DOI":"10.17863\/CAM.11344"},{"key":"key-10.17116\/oftalma202414001158-5","unstructured":"Registr lekarstvennyh sredstv Rossii. 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Pharmacotherapeutic effectiveness of the drug \u00abKorneregel\u00bb in the complex treatment of keratitis of viral etiology. Vestnik Buryatskogo gosudarstvennogo universiteta. Medicina i farmaciya. 2017;(1):79-84. (In Russ.)"},{"key":"key-10.17116\/oftalma202414001158-17","unstructured":"Moshetova LK, Chernakova GM, Yarlykova IV. The use of floxal and korneregel in patients with mechanical and infectious complications of contact vision correction. RMZh. Klinicheskaya oftal\u2019mologiya. 2002;3(1):26-28. (In Russ.)"},{"key":"key-10.17116\/oftalma202414001158-18","unstructured":"Kirisenko LI, Oparina AE, Puchkina EV. Comparative assessment of the use of  orneregel and Actovegin eye gel in patients after cataract extraction. RMZh. Klinicheskaya oftal\u2019mologiya. 2003;(4):178-179. 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