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When formiate accumulates, tissue respiration is disrupted, leading to pronounced tissue hypoxia. As a result of such methanol metabolism, metabolic acidosis occurs. Tissue hypoxia develops in the first few hours as a result of the action of formic acid on the respiratory enzyme chain at the cytochrome oxidase level. Hypoxia and, as a consequence, a decrease in energy supply lead to a disruption of biological oxidation and the development of apoptosis in the optic nerve fibers. Understanding the process of optic nerve atrophy development at the pathogenetic level in methyl alcohol intoxication will help make a correct early diagnosis and prescribe timely treatment.<\/jats:p>","DOI":"10.17116\/oftalma202414002191","type":"journal-article","created":{"date-parts":[[2024,5,14]],"date-time":"2024-05-14T09:57:10Z","timestamp":1715680630000},"page":"91","source":"Crossref","is-referenced-by-count":1,"title":["Pathogenetic basis of optic nerve atrophy in methanol poisoning"],"prefix":"10.17116","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0863-7762","authenticated-orcid":false,"given":"A.N.","family":"Samoylov","sequence":"first","affiliation":[{"name":"Kazan State Medical University","place":["Kazan, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9009-1273","authenticated-orcid":false,"given":"A.M.","family":"Barieva","sequence":"additional","affiliation":[{"name":"Kazan State Medical University","place":["Kazan, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-9560-8223","authenticated-orcid":false,"given":"A.A.","family":"Kuznetsova","sequence":"additional","affiliation":[{"name":"Kazan State Medical University","place":["Kazan, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/oftalma202414002191-1","unstructured":"Shpak NI, Dmitrieva MO, Fedorova LI. 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