{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T15:51:49Z","timestamp":1787068309314,"version":"build-2736575974"},"reference-count":70,"publisher":"Media Sphere Publishing House","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. Ann. Ophthal."],"published-print":{"date-parts":[[2024,4,23]]},"abstract":"<jats:p>The lacrimal gland (LG) is a tubuloacinar exocrine gland composed of acinar, ductal, and myoepithelial cells. Three-dimensional distribution of acinar lobules, ducts, and myoepithelial cells is necessary for the effective functioning of the organ. LG is the main organ of immune surveillance of the ocular surface system. The embryogenesis of the gland is regulated by the interaction of genetic mechanisms, internal epigenetic (enzyme systems, hormones) and exogenous factors. There is no doubt that there is a clear genetic program for the implementation of the complex process of embryonic development. The mechanisms regulating LG organogenesis initiate the work of a huge number of structural oncogenes, transcription and growth factors, etc. Studying the expression and selective activity of regulatory genes during organ development, their participation in the differentiation of different cell types is a current trend at the nexus of clinical genetics, molecular biology, embryology and immunocytochemistry. Due to its relatively simple structure and accessibility, human LG is a suitable object for potential application in regenerative medicine. Development of a universal protocol for obtaining functional differentiated secretory epithelium of LG capable of expressing tissue-specific markers is an urgent task. Determining the nature and origin of stem cells and progenitor cells will allow the isolation and multiplication of these cells in culture. After obtaining a functionally active culture of LG cells, it is possible to create a model of autoimmune diseases.<\/jats:p>","DOI":"10.17116\/oftalma2024140022158","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:03:15Z","timestamp":1715612595000},"page":"158","source":"Crossref","is-referenced-by-count":1,"special_numbering":"Vyp. 2","title":["Cell technologies as a basis for the development of regenerative principles for the treatment of lacrimal gland diseases"],"prefix":"10.17116","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4601-0904","authenticated-orcid":false,"given":"T.N.","family":"Safonova","sequence":"first","affiliation":[{"name":"Krasnov Research Institute of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8575-3076","authenticated-orcid":false,"given":"G.V.","family":"Zaitseva","sequence":"additional","affiliation":[{"name":"Krasnov Research Institute of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6743","reference":[{"key":"key-10.17116\/oftalma2024140022158-1","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000247220.18295.d3"},{"key":"key-10.17116\/oftalma2024140022158-2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2014.06.003"},{"key":"key-10.17116\/oftalma2024140022158-3","doi-asserted-by":"publisher","DOI":"10.1016\/j.preteyeres.2009.04.003"},{"key":"key-10.17116\/oftalma2024140022158-4","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0b013e3182833dee"},{"key":"key-10.17116\/oftalma2024140022158-5","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2020.1774065"},{"key":"key-10.17116\/oftalma2024140022158-6","doi-asserted-by":"publisher","DOI":"10.3109\/02713689109020347"},{"key":"key-10.17116\/oftalma2024140022158-7","unstructured":"Linsen C, Missotten L. Physiology of the lacrimal system. Bull Soc Belge Ophtalmol. 1990;238:35-44"},{"key":"key-10.17116\/oftalma2024140022158-8","doi-asserted-by":"publisher","DOI":"10.3389\/fimmu.2021.779709"},{"key":"key-10.17116\/oftalma2024140022158-9","doi-asserted-by":"crossref","unstructured":"Kett K, Brandtzaeg P, Radl J, Haaijman JJ. Different subclass distribution of IgA-producing cells in human lymphoid organs and various secretory tissues. J Immunol. 1986;136(10):3631-3635","DOI":"10.4049\/jimmunol.136.10.3631"},{"key":"key-10.17116\/oftalma2024140022158-10","unstructured":"Safonova TN, Vasil\u2019ev VI, Lihvanceva VG. Sindrom Shegrena. M.: Izdatel\u2019stvo Moskovskogo Universiteta; 2013. (In Russ.)"},{"key":"key-10.17116\/oftalma2024140022158-11","doi-asserted-by":"publisher","DOI":"10.1007\/BF0091884"},{"key":"key-10.17116\/oftalma2024140022158-12","doi-asserted-by":"publisher","DOI":"10.3109\/02713689609008901"},{"key":"key-10.17116\/oftalma2024140022158-13","doi-asserted-by":"publisher","DOI":"10.1242\/dev.01285"},{"key":"key-10.17116\/oftalma2024140022158-14","doi-asserted-by":"publisher","DOI":"10.1006\/dbio.2000.981"},{"key":"key-10.17116\/oftalma2024140022158-15","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2015.11.020"},{"key":"key-10.17116\/oftalma2024140022158-16","doi-asserted-by":"publisher","DOI":"10.1002\/dvdy.24551"},{"key":"key-10.17116\/oftalma2024140022158-17","doi-asserted-by":"publisher","DOI":"10.2186\/jjps.48.723"},{"key":"key-10.17116\/oftalma2024140022158-18","doi-asserted-by":"publisher","DOI":"10.5402\/2012\/640956"},{"key":"key-10.17116\/oftalma2024140022158-19","doi-asserted-by":"publisher","DOI":"10.1038\/nature04372"},{"key":"key-10.17116\/oftalma2024140022158-20","doi-asserted-by":"publisher","DOI":"10.3390\/jfb6030634"},{"key":"key-10.17116\/oftalma2024140022158-21","doi-asserted-by":"publisher","DOI":"10.1016\/j.exer.2007.01.01"},{"key":"key-10.17116\/oftalma2024140022158-22","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-1830"},{"key":"key-10.17116\/oftalma2024140022158-23","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-11"},{"key":"key-10.17116\/oftalma2024140022158-24","doi-asserted-by":"publisher","DOI":"10.1038\/ncomms3497"},{"key":"key-10.17116\/oftalma2024140022158-25","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-021-02133-y"},{"key":"key-10.17116\/oftalma2024140022158-26","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-017-06369-8"},{"key":"key-10.17116\/oftalma2024140022158-27","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-019-1541-1"},{"key":"key-10.17116\/oftalma2024140022158-28","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.8.4.32"},{"key":"key-10.17116\/oftalma2024140022158-29","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEA.2015.0286"},{"key":"key-10.17116\/oftalma2024140022158-30","doi-asserted-by":"publisher","DOI":"10.1002\/term.2631"},{"key":"key-10.17116\/oftalma2024140022158-31","unstructured":"Rismondo V, Gierow JP, Lambert RW, Golchini K, Feldon SE, Mircheff AK. Rabbit lacrimal acinar cells in primary culture: Morphology and acute responses to cholinergic stimulation. Invest Ophthalmol Vis Sci. 1994;35:1176-1183"},{"key":"key-10.17116\/oftalma2024140022158-32","doi-asserted-by":"publisher","DOI":"10.1016\/s1542-0124(12)70222-7"},{"key":"key-10.17116\/oftalma2024140022158-33","doi-asserted-by":"publisher","DOI":"10.1007\/978-1-4615-0717-8_21"},{"key":"key-10.17116\/oftalma2024140022158-34","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0029458"},{"key":"key-10.17116\/oftalma2024140022158-35","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.08-2503"},{"key":"key-10.17116\/oftalma2024140022158-36","doi-asserted-by":"publisher","DOI":"10.1007\/BF02628416"},{"key":"key-10.17116\/oftalma2024140022158-37","unstructured":"Meneray MA, Fields TY, Bromberg BB. Morphology and physiologic responsiveness of cultured rabbit lacrimal acini. Invest Ophthalmol Vis Sci. 1994;35:4144-4158"},{"key":"key-10.17116\/oftalma2024140022158-38","unstructured":"Hann LE, Kelleher RS, Sullivan DA. Influence of culture conditions on the androgen control of secretory component production by acinar cells from the rat lacrimal gland. Invest ophthalmol Vis Sci. 1991;32:2610-2621"},{"key":"key-10.17116\/oftalma2024140022158-39","doi-asserted-by":"publisher","DOI":"10.1006\/exer.2000.0824"},{"key":"key-10.17116\/oftalma2024140022158-40","doi-asserted-by":"publisher","DOI":"10.1002\/jbm.b.30502"},{"key":"key-10.17116\/oftalma2024140022158-41","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-007-0612-7"},{"key":"key-10.17116\/oftalma2024140022158-42","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2008.137927"},{"key":"key-10.17116\/oftalma2024140022158-43","doi-asserted-by":"publisher","DOI":"10.1016\/j.sjopt.2013.09.004"},{"key":"key-10.17116\/oftalma2024140022158-44","doi-asserted-by":"publisher","DOI":"10.1016\/s1542-0124(12)70070-8"},{"key":"key-10.17116\/oftalma2024140022158-45","doi-asserted-by":"publisher","DOI":"10.1189\/jlb.2A0715-307R"},{"key":"key-10.17116\/oftalma2024140022158-46","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.14-16307"},{"key":"key-10.17116\/oftalma2024140022158-47","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-7893"},{"key":"key-10.17116\/oftalma2024140022158-48","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5686"},{"key":"key-10.17116\/oftalma2024140022158-49","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.11-9025"},{"key":"key-10.17116\/oftalma2024140022158-50","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-5686"},{"key":"key-10.17116\/oftalma2024140022158-51","doi-asserted-by":"publisher","DOI":"10.1007\/s00441-011-1271-x"},{"key":"key-10.17116\/oftalma2024140022158-52","unstructured":"Kobayashi S, Kawakita T, Kawashima M, Okada N, Mishima K, Saito I, Ito M, Shimmura S, Tsubota K. Characterization of cultivated murine lacrimal gland epithelial cells. Mol Vis. 2012;18:1271-1277"},{"key":"key-10.17116\/oftalma2024140022158-53","doi-asserted-by":"publisher","DOI":"10.5966\/sctm.2016-0191"},{"key":"key-10.17116\/oftalma2024140022158-54","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-16475"},{"key":"key-10.17116\/oftalma2024140022158-55","doi-asserted-by":"publisher","DOI":"10.1097\/00003226-200005001-00007"},{"key":"key-10.17116\/oftalma2024140022158-56","doi-asserted-by":"publisher","DOI":"10.1167\/tvst.8.4.32"},{"key":"key-10.17116\/oftalma2024140022158-57","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-018-3926-8"},{"key":"key-10.17116\/oftalma2024140022158-58","doi-asserted-by":"publisher","DOI":"10.1089\/ten.TEA.2014.0694"},{"key":"key-10.17116\/oftalma2024140022158-59","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-021-01872-9"},{"key":"key-10.17116\/oftalma2024140022158-60","doi-asserted-by":"publisher","DOI":"10.1242\/dev.127.12.2563"},{"key":"key-10.17116\/oftalma2024140022158-61","doi-asserted-by":"publisher","DOI":"10.1111\/j.1399-0004.2006.00597.x"},{"key":"key-10.17116\/oftalma2024140022158-62","doi-asserted-by":"publisher","DOI":"10.1038\/sj.ejhg.5201762"},{"key":"key-10.17116\/oftalma2024140022158-63","doi-asserted-by":"publisher","DOI":"10.1016\/j.isci.2020.101230"},{"key":"key-10.17116\/oftalma2024140022158-64","doi-asserted-by":"publisher","DOI":"10.1038\/s41598-019-54840-5"},{"key":"key-10.17116\/oftalma2024140022158-65","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.15-17477"},{"key":"key-10.17116\/oftalma2024140022158-66","doi-asserted-by":"publisher","DOI":"10.1074\/jbc.M111.225003"},{"key":"key-10.17116\/oftalma2024140022158-67","doi-asserted-by":"publisher","DOI":"10.1242\/dev.150789"},{"key":"key-10.17116\/oftalma2024140022158-68","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.64.1.21"},{"key":"key-10.17116\/oftalma2024140022158-69","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31823f8e47"},{"key":"key-10.17116\/oftalma2024140022158-70","doi-asserted-by":"publisher","DOI":"10.1186\/s13287-017-0593-3"}],"container-title":["Russian Annals of Ophthalmology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T08:41:07Z","timestamp":1745397667000},"score":1,"resource":{"primary":{"URL":"https:\/\/mediasphera.ru\/issues\/vestnik-oftalmologii\/2024\/2-2\/10042465X2024022158"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":70,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6,10]]}},"alternative-id":["10.17116\/oftalma2024140022158"],"URL":"https:\/\/doi.org\/10.17116\/oftalma2024140022158","relation":{},"ISSN":["0042-465X"],"issn-type":[{"value":"0042-465X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4,23]]}}}