{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T02:03:10Z","timestamp":1787623390250,"version":"build-2736575974"},"reference-count":12,"publisher":"Media Sphere Publishing House","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. Ann. Ophthal."],"published-print":{"date-parts":[[2024,4,23]]},"abstract":"<jats:p>Optical coherence tomography (OCT) is currently widely used for the diagnosis of choroidal melanoma (CM), but the problem of predicting the outcomes of planned CM treatment remains unsolved. Purpose. This study was conducted to identify OCT signs that adversely affect the outcome of organ-preserving CM treatment. Material and methods. OCT scan images of 30 patients who underwent organ-preserving treatment and were under observation were selected for this study. Brachytherapy (BT) as monotherapy was performed in 27 patients (in 2 cases \u2014 twice, and in 1 case \u2014 three times), in one patient \u2014 in combination with the previous transpupillary thermotherapy (TTT). Multiple TTT (4 sessions within 4 months) as monotherapy were performed in 2 patients. In 9 cases, a single organ-preserving treatment (BT \u2014 6 patients, TTT \u2014 3 patients) was ineffective. In these cases, the effectiveness of the first stage of organ-preserving treatment was taken into account. Results. Seven signs of an unfavorable prognosis of the performed treatment were identified by analyzis of tomograms and statistical processing of the obtained data. These signs include: the presence of intraretinal edema, detachment of the neuroepithelium (NED) over the tumor, including with a break in the photoreceptors, accumulation of transudate over the tumor, the presence of large cysts, intraretinal cavities and NED near the tumor (secondary retinal detachment). A combination of three or more signs were observed in all cases of inefficiency of the first stage of treatment. Most often, intraretinal edema and NED over the tumor were combined with the accumulation of subretinal transudate and NED near the tumor. The presence of 6 or all 7 signs took place in cases of a negative therapeutic effect after local destruction. Conclusion. When planning organ-preserving CM treatment, in addition to biometric parameters, it is necessary to pay special attention to the identification of such morphological signs as NED over and near the tumor, accumulation of transudate under the NED, the presence of intraretinal edema, large intraretinal cysts and cavities.<\/jats:p>","DOI":"10.17116\/oftalma202414002216","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:03:15Z","timestamp":1715612595000},"page":"16","source":"Crossref","is-referenced-by-count":1,"special_numbering":"Vyp. 2","title":["Predicting the effectiveness of organ-preserving treatment of choroidal melanoma using optical coherence tomography data"],"prefix":"10.17116","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4517-0324","authenticated-orcid":false,"given":"A.S.","family":"Stoyukhina","sequence":"first","affiliation":[{"name":"Krasnov Research Institute of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6743","reference":[{"key":"key-10.17116\/oftalma202414002216-1","unstructured":"Brovkina AF. eds. Ophthalmooncologiya: Rukovodstvo dlya vracey. Pod red. Brovkina A.F. M.: Medicina; 2002. (In Russ.)"},{"key":"key-10.17116\/oftalma202414002216-2","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.01.032"},{"key":"key-10.17116\/oftalma202414002216-3","doi-asserted-by":"publisher","DOI":"10.1136\/bjo.2009.176198"},{"key":"key-10.17116\/oftalma202414002216-4","unstructured":"Gragoudas ES. A randomized, controlled trial of varying radiation doses in the treatment of choroidal melanoma. Trans Am Ophthalmol Soc. 1998;96: 691-720"},{"key":"key-10.17116\/oftalma202414002216-5","doi-asserted-by":"publisher","DOI":"10.17116\/oftalma201813404152"},{"key":"key-10.17116\/oftalma202414002216-6","doi-asserted-by":"publisher","DOI":"10.18008\/1816-5095-2020-2-195-201"},{"key":"key-10.17116\/oftalma202414002216-7","unstructured":"Linnik LF, Magaramov DA, Yarovoi AA, Semikova TS, Ronkina TI, Bulgakova ES. Trekhletniy opyt primeneniya transpupillyarnoy diod\u2014lazernoy termoterapii kak samostoyatel\u2019nogo metoda lecheniya uveal\u2019nykh melanom. Oftal\u2019mohirurgiya. 2003;(4):17-24.(In Russ.)"},{"key":"key-10.17116\/oftalma202414002216-8","unstructured":"Yarovoi AA, Linnik LF, Magaramov DA, Semikova TS, Ioileva EA, Bulgakova ES. Transpupillary diode \u2014 laser thermotherapy \u2014 possibilities of treatment of small melanoma of chorioidea. RMZh \u00abKlinicheskaya oftal\u2019mologiya\u00bb. 2004;5(2):77-81. (In Russ.)"},{"key":"key-10.17116\/oftalma202414002216-9","unstructured":"Saakyan SV, Neroev VV, Yurovskaya NN, Ryabina MV, Myakoshina EB, Tatskov RA. Sposob diagnostiki vnutriglazhyh novoobrazovaniy. Patent RF na izobreteniye \u21162387378\/27.04.2010 Byul. \u211612. Accessed 11.10.2023. (In Russ.)"},{"key":"key-10.17116\/oftalma202414002216-10","unstructured":"Stoyukhina AS, Brovkina AF, Budzinskaya MV. Sposob prizhiznennogo vyyavleniya prorastaniya melanomy khorioidei v setchatku. Patent RF na izobreteniye \u21162703979\/22.10.2019. Byul. \u211630. Accessed 11.10.23. (In Russ.)"},{"key":"key-10.17116\/oftalma202414002216-11","unstructured":"Neroev VV, Saakyan SV, Myakoshina EB. Sposob opredeleniya pokazaniy k povtornoy destruktsii nachal\u2019noy melanomy horioidei. Patent RF na izobreteniye \u21162665185\/28.08.2018 Byul. \u211625. Accessed 11.10.2023. (In Russ.)"},{"key":"key-10.17116\/oftalma202414002216-12","unstructured":"Stoyukhina AS, Brovkina AF, Budzinskaya MV. Sposob differentsial\u2019noy diagnostiki giperplazii pigmenta i ostatochnoy opukholi v rubtse posle brakhiterapii melanomy horioidei. Patent RF na izobreteniye \u21162724280\/22.06.2020 Byul. \u211618 Accessed 11.10.23. (In Russ.)"}],"container-title":["Russian Annals of Ophthalmology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T08:40:09Z","timestamp":1745397609000},"score":1,"resource":{"primary":{"URL":"https:\/\/mediasphera.ru\/issues\/vestnik-oftalmologii\/2024\/2-2\/10042465X2024022016"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":12,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6,10]]}},"alternative-id":["10.17116\/oftalma202414002216"],"URL":"https:\/\/doi.org\/10.17116\/oftalma202414002216","relation":{},"ISSN":["0042-465X"],"issn-type":[{"value":"0042-465X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4,23]]}}}