{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:23:34Z","timestamp":1747200214068,"version":"3.40.5"},"reference-count":20,"publisher":"Media Sphere Publishing House","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. Ann. Ophthal."],"published-print":{"date-parts":[[2024,4,23]]},"abstract":"<jats:p>Chronic mixed blepharitis accounts for 51.7% of all ophthalmic diseases. The use of laser Doppler flowmetry (LDF) in the diagnosis of this disease can help establish the initial manifestations of the inflammatory process in the eyelids, which is important for the prevention of possible complications \u2014 dry eye disease. Purpose. This study was conducted to determine the sensitivity and specificity of the LDF method in the diagnosis of chronic mixed blepharitis based on the study of microcirculatory changes in the eyelid skin. Material and methods. The study included 23 patients with chronic mixed blepharitis (mean age 67\u00b15.8 years) and 18 healthy volunteers (mean age 63\u00b11.1 years). LDF was performed using the LAZMA MC-1 device. ROC analysis was used to determine sensitivity and specificity. Results. A typical disturbance of the eyelid skin microcirculation was revealed in chronic mixed blepharitis \u2014 ischemia \u2014 with inhibition of the intensity of the functioning of blood flow regulatory systems and moderate activation of the lymph flow. The sensitivity and specificity of the coefficient of variation (reflecting the vasomotor activity of microvessels) of blood flow was 71.43 and 71.43%, lymph flow \u2014 65.71 and 80.00%; myogenic rhythms of blood flow \u2014 83.33 and 85.71%, lymph flow \u2014 66.67 and 71.43%; neurogenic rhythms of blood flow \u2014 75.00 and 78.57%, lymph flow \u2014 91.67 and 78.57%, respectively. Conclusion. Laser Doppler flowmetry of the eyelid skin in combination with clinical, functional and instrumental research methods helped reveal with high sensitivity and specificity the eyelid damage in chronic mixed blepharitis. This method allows assessment of the condition of the eyelids in individuals without diseases of the anterior segment of the eye.<\/jats:p>","DOI":"10.17116\/oftalma202414002268","type":"journal-article","created":{"date-parts":[[2024,5,13]],"date-time":"2024-05-13T15:03:15Z","timestamp":1715612595000},"page":"68","source":"Crossref","is-referenced-by-count":0,"special_numbering":"Vyp. 2","title":["Laser Doppler flowmetry in the diagnosis of chronic mixed blepharitis"],"prefix":"10.17116","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4601-0904","authenticated-orcid":false,"given":"T.N.","family":"Safonova","sequence":"first","affiliation":[{"name":"Krasnov Research Institute of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2740-2793","authenticated-orcid":false,"given":"N.P.","family":"Kintyukhina","sequence":"additional","affiliation":[{"name":"Krasnov Research Institute of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2728-650X","authenticated-orcid":false,"given":"E.I.","family":"Timoshenkova","sequence":"additional","affiliation":[{"name":"Krasnov Research Institute of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/oftalma202414002268-1","doi-asserted-by":"publisher","DOI":"10.25276\/0235-4160-2017-1-78-82"},{"key":"key-10.17116\/oftalma202414002268-2","unstructured":"Safonova TN, Kintyukhina NP, Petrenko AE, Gladkova OV. First experience of \u00abDeksodem phyto\u00bb use in treating chronic demodex blepharitis. Tochka Zreniya. Vostok \u2014 Zapad. 2016;1:145-147. (In Russ.)"},{"key":"key-10.17116\/oftalma202414002268-3","doi-asserted-by":"crossref","unstructured":"Safonova TN, Kintyukhina NP, Sidorov VV, Gladkova OV. Laser doppler flowmetry in assessing the effectiveness of treatment of chronic demodex blefaritis. Rossiiskii oftal\u2019mologicheskii zhurnal. 2017;10(2):62-66. (In Russ.)","DOI":"10.21516\/2072-0076-2017-10-2-62-66"},{"key":"key-10.17116\/oftalma202414002268-4","doi-asserted-by":"publisher","DOI":"10.1016\/j.mvr.2022.104373"},{"key":"key-10.17116\/oftalma202414002268-5","unstructured":"Filatova IA, Shemetov SA. Results of microhemocirculation assessment after surgical treatment using polytetrafluoroethylene implants. Annaly plasticheskoi, rekonstruktivnoi i esteticheskoi khirurgii 2018;4:135. (In Russ.)"},{"key":"key-10.17116\/oftalma202414002268-6","doi-asserted-by":"publisher","DOI":"10.1089\/photob.2020.4913"},{"key":"key-10.17116\/oftalma202414002268-7","unstructured":"Lazernaya dopplerovskaya floumetriya mikrotsirkulyatsii krovi. Pod. red. Krupatkina A.I., Sidorova V.V. M.: Izdatel\u2019stvovo Meditsina; 2005. (In Russ.)"},{"key":"key-10.17116\/oftalma202414002268-8","unstructured":"Krupatkin AI, Sidorov VV. Funktsional\u2019naya diagnostika sostoyaniya mikrotsirkulyatorno-tkanevykh sistem. M.: Knizhnyi dom \u00abLibrokom\u00bb, 2014. (In Russ.)"},{"key":"key-10.17116\/oftalma202414002268-9","doi-asserted-by":"publisher","DOI":"10.17116\/oftalma2017133316-21"},{"key":"key-10.17116\/oftalma202414002268-10","doi-asserted-by":"publisher","DOI":"10.3109\/08820538.2010.488562"},{"key":"key-10.17116\/oftalma202414002268-11","doi-asserted-by":"publisher","DOI":"10.1016\/j.det.2016.05.010"},{"key":"key-10.17116\/oftalma202414002268-12","unstructured":"Abramovich SG, Mashanskaya AV. Laser doppler flowmetry in estimation of microcirculation in healthy people and patients with arterial hypertension. Sibirskii meditsinskii zhurnal. 2010;1:57-59. (In Russ.)"},{"key":"key-10.17116\/oftalma202414002268-13","doi-asserted-by":"publisher","DOI":"10.24884\/1682-6655-2021-20-4-106-109"},{"key":"key-10.17116\/oftalma202414002268-14","unstructured":"Rogatkin DA. Physical foundations of modern optical methods for studying microhemodynamics in vivo. Lecture. Meditsinskaya fizika. 2017;4:75-93. (In Russ.)"},{"key":"key-10.17116\/oftalma202414002268-15","doi-asserted-by":"publisher","DOI":"10.18705\/1607-419X-2019-25-1-74-83"},{"key":"key-10.17116\/oftalma202414002268-16","doi-asserted-by":"publisher","DOI":"10.17537\/2020.15.416"},{"key":"key-10.17116\/oftalma202414002268-17","doi-asserted-by":"publisher","DOI":"10.3389\/fmed.2022.820119"},{"key":"key-10.17116\/oftalma202414002268-18","doi-asserted-by":"publisher","DOI":"10.7556\/jaoa.2014.178"},{"key":"key-10.17116\/oftalma202414002268-19","doi-asserted-by":"publisher","DOI":"10.1016\/j.archoralbio.2017.11.009"},{"key":"key-10.17116\/oftalma202414002268-20","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph17238787"}],"container-title":["Russian Annals of Ophthalmology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T08:40:23Z","timestamp":1745397623000},"score":1,"resource":{"primary":{"URL":"https:\/\/mediasphera.ru\/issues\/vestnik-oftalmologii\/2024\/2-2\/10042465X2024022068"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":20,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2024,6,10]]}},"alternative-id":["10.17116\/oftalma202414002268"],"URL":"https:\/\/doi.org\/10.17116\/oftalma202414002268","relation":{},"ISSN":["0042-465X"],"issn-type":[{"type":"print","value":"0042-465X"}],"subject":[],"published":{"date-parts":[[2024,4,23]]}}}