{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:23:35Z","timestamp":1747200215212,"version":"3.40.5"},"reference-count":20,"publisher":"Media Sphere Publishing House","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. Ann. Ophthal."],"published-print":{"date-parts":[[2024,4,23]]},"abstract":"<jats:p>Multiple sclerosis (MS) is a chronic autoimmune-inflammatory and neurodegenerative disease. Purpose. This study explores the main structural changes in patients with MS and their relationships with the activity and type of disease course. Material and methods. This prospective study included 159 patients (318 eyes) with an established diagnosis of MS: group (44 eyes; 13.84%) \u2014 relapsing-remitting type MS (RRMS) lasting up to 1 year without a history of optic neuritis (ON); group 2 (30 eyes; 9.43%) \u2014 RRMS up to 1 year with ON; group 3 (56 eyes; 17.61%) \u2014 RRMS lasting from 1 to 10 years without ON; group 4 (38 eyes; 11.95%) \u2014 RRMS from 1 to 10 years with ON; group 5 (49 eyes; 15.41%) \u2014 RRMS &gt;10 years without ON; group 6 (37 eyes; 11.63%) \u2014 RRMS &gt;10 years with ON; group 7 (34 eyes; 10.69%) \u2014 secondary progressive multiple sclerosis (SPMS) without ON; group 8 (30 eyes; 9.43%) \u2014 SPMS with ON. Patients underwent standard ophthalmological examinations, including optical coherence tomography. Results. A decrease in structural parameters was diagnosed, progressing with the duration of the disease and the presence of ON: the minimum values of mGCL+IPL (65.83\u00b19.14 \u03bcm) and mSNFL (76.37\u00b114.77 \u03bcm) were detected in the group with SPMS with ON. High inverse correlations of EDSS with mGCL+IPL and mRNFL were demonstrated, with maximum in the group with the longest duration of MS without ON (\u20130.48 and -0.52 (p=0.01), respectively). Conclusion. Changes in the thickness of the structural parameters of the retina, measured by OCT, can be considered as a predictor of the course of MS.<\/jats:p>","DOI":"10.17116\/oftalma202414003159","type":"journal-article","created":{"date-parts":[[2024,7,4]],"date-time":"2024-07-04T10:09:23Z","timestamp":1720087763000},"page":"59","source":"Crossref","is-referenced-by-count":0,"title":["Optical coherence tomography in the diagnosis of multiple sclerosis"],"prefix":"10.17116","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6311-5452","authenticated-orcid":false,"given":"A.Zh.","family":"Fursova","sequence":"first","affiliation":[{"name":"Novosibirsk State Regional Clinical Hospital","place":["Novosibirsk, Russia"]},{"name":"Novosibirsk State Medical University","place":["Novosibirsk, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3071-3285","authenticated-orcid":false,"given":"M.Yu.","family":"Zubkova","sequence":"additional","affiliation":[{"name":"Novosibirsk State Regional Clinical Hospital","place":["Novosibirsk, Russia"]},{"name":"Novosibirsk State Medical University","place":["Novosibirsk, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2974-9325","authenticated-orcid":false,"given":"M.A.","family":"Vasilyeva","sequence":"additional","affiliation":[{"name":"Novosibirsk State Regional Clinical Hospital","place":["Novosibirsk, Russia"]},{"name":"Novosibirsk State Medical University","place":["Novosibirsk, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1474-4468","authenticated-orcid":false,"given":"Yu.A.","family":"Karlash","sequence":"additional","affiliation":[{"name":"Novosibirsk State Regional Clinical Hospital","place":["Novosibirsk, Russia"]},{"name":"Novosibirsk State Medical University","place":["Novosibirsk, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2208-8352","authenticated-orcid":false,"given":"I.F.","family":"Nikulich","sequence":"additional","affiliation":[{"name":"Novosibirsk State Regional Clinical Hospital","place":["Novosibirsk, Russia"]},{"name":"Novosibirsk State Medical University","place":["Novosibirsk, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8825-3656","authenticated-orcid":false,"given":"A.S.","family":"Derbeneva","sequence":"additional","affiliation":[{"name":"Novosibirsk State Regional Clinical Hospital","place":["Novosibirsk, Russia"]},{"name":"Novosibirsk State Medical University","place":["Novosibirsk, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/oftalma202414003159-1","doi-asserted-by":"publisher","DOI":"10.1089\/nsm.2020.0006"},{"key":"key-10.17116\/oftalma202414003159-2","doi-asserted-by":"publisher","DOI":"10.17116\/oftalma2023139061175"},{"key":"key-10.17116\/oftalma202414003159-3","doi-asserted-by":"publisher","DOI":"10.21516\/2072-0076-2021-14-1-104-110"},{"key":"key-10.17116\/oftalma202414003159-4","doi-asserted-by":"publisher","DOI":"10.3390\/cells10061507"},{"key":"key-10.17116\/oftalma202414003159-5","doi-asserted-by":"publisher","DOI":"10.1016\/S1474-4422(17)30470-2"},{"key":"key-10.17116\/oftalma202414003159-6","unstructured":"Neurology: national guide [Nevrologiya: natsional\u2019noye rukovodstvo]: in 2 volumes. 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