{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:23:38Z","timestamp":1747200218870,"version":"3.40.5"},"reference-count":40,"publisher":"Media Sphere Publishing House","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. Ann. Ophthal."],"published-print":{"date-parts":[[2024,4,23]]},"abstract":"<jats:p>Purpose. This study compares the effectiveness of various approaches to improvement of ocular surface condition in primary open-angle glaucoma (POAG) patients with dry eye syndrome (DES) and meibomian gland dysfunction (MGD). Material and methods. The study included 48 patients with stage II POAG, compensated with a fixed-combinations of dorzolamide and timolol (FC-DT) containing benzalkonium chloride (BAC), in the presence of DES and MGD. After randomization, patients in group 1 (n=24) received FC-DT without BAC along with eyelid hygiene (\u201cBlepharogel cleansing\u201d, \u201cBlepharolotion\u201d, \u201cBlepharogel-1\u201d), while patients in group 2 received only FC-DT without BAC. The control points (CP) were: 1 \u2014 at baseline, 2 \u2014 after 4 weeks of therapy. Changes in OSDI score, tear break-up time (TBUT), Bijsterveld\u2019s xerosis index (XI), MGD severity, and intraocular pressure (IOP) were assessed at each CP. Results. By the second CP, in group 1 significant improvements were observed in OSDI, TBUT, XI, and MGD severity by the 2nd CP, while in group 2 \u2014 in OSDI and TBUT. The improvements in OSDI and TBUT were significantly more pronounced in group 1, likely due to the reduction in MGD severity. The changes in IOP in both groups were insignificant. Conclusion. In patients with POAG, DES, and MGD who are undergoing therapy with BAC-containing medications, an approach involving switching to BAC-free eye drops combined with eyelid hygiene (using \u201cBlepharogel cleansing\u201d, \u201cBlepharolotion\u201d, and \u201cBlepharogel-1\u201d) proved to be more effective than the approach of switching to BAC-free medications without additional eyelid hygiene.<\/jats:p>","DOI":"10.17116\/oftalma20241400517","type":"journal-article","created":{"date-parts":[[2024,11,21]],"date-time":"2024-11-21T12:30:43Z","timestamp":1732192243000},"page":"7","source":"Crossref","is-referenced-by-count":0,"title":["Approaches for improvement of ocular surface condition in primary open-angle glaucoma"],"prefix":"10.17116","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7371-689X","authenticated-orcid":false,"given":"S.V.","family":"Yanchenko","sequence":"first","affiliation":[{"name":"Bukhara State Medical Institute named after Abu Ali ibn Sino","place":["Bukhara, Uzbekistan"]},{"name":"Bukhara branch of the Republican Specialized Scientific and Practical Center for Eye Microsurgery","place":["Bukhara, Uzbekistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2100-2972","authenticated-orcid":false,"given":"S.N.","family":"Sakhnov","sequence":"additional","affiliation":[{"name":"Kuban State Medical University","place":["Krasnodar, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1448-9690","authenticated-orcid":false,"given":"A.V.","family":"Malyshev","sequence":"additional","affiliation":[{"name":"Kuban State Medical University","place":["Krasnodar, Russia"]},{"name":"Maykop State Technological University","place":["Maykop, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-1996-4275","authenticated-orcid":false,"given":"Sh.Zh.","family":"Teshaev","sequence":"additional","affiliation":[{"name":"Bukhara State Medical Institute named after Abu Ali ibn Sino","place":["Bukhara, Uzbekistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3268-7156","authenticated-orcid":false,"given":"S.S.","family":"Davlatov","sequence":"additional","affiliation":[{"name":"Bukhara State Medical Institute named after Abu Ali ibn Sino","place":["Bukhara, Uzbekistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0002-2271-2933","authenticated-orcid":false,"given":"Z.O.","family":"Sapharov","sequence":"additional","affiliation":[{"name":"Bukhara State Medical Institute named after Abu Ali ibn Sino","place":["Bukhara, Uzbekistan"]},{"name":"Bukhara branch of the Republican Specialized Scientific and Practical Center for Eye Microsurgery","place":["Bukhara, Uzbekistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6480-1822","authenticated-orcid":false,"given":"E.A.","family":"Haribova","sequence":"additional","affiliation":[{"name":"Bukhara State Medical Institute named after Abu Ali ibn Sino","place":["Bukhara, Uzbekistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0008-3548-0581","authenticated-orcid":false,"given":"B.G.","family":"Hamroev","sequence":"additional","affiliation":[{"name":"Bukhara State Medical Institute named after Abu Ali ibn Sino","place":["Bukhara, Uzbekistan"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/oftalma20241400517-1","unstructured":"National guidelines for glaucoma for practitioners. Ed. 4th, corrected and supplemented. Edited by Egorov EA, Erichev VP. M.: GEOTAR-Media; 2019:383 (In Russ.)"},{"key":"key-10.17116\/oftalma20241400517-2","unstructured":"Medical Treatment of Glaucoma. WGA Consensus Series \u2014 7. Weinreb R, Makoto A, Susanna R, Goldberg I, Migdal C, Liebmann J, eds. Kugler Publications; 2010:309"},{"key":"key-10.17116\/oftalma20241400517-3","unstructured":"Terminology and guidelines for glaucoma. 5th edition. EGS; 2020:168"},{"key":"key-10.17116\/oftalma20241400517-4","doi-asserted-by":"crossref","unstructured":"Kahook MY, Noecker R. Quantitative analysis of conjunctival goblet cells after chronic application of topical drops. Adv Ther. 2008;25(8):743-751","DOI":"10.1007\/s12325-008-0078-y"},{"key":"key-10.17116\/oftalma20241400517-5","unstructured":"Erb C. Glaucoma and Dry Eye. Bremen: UNI-MED Verlag AG; 2012:102"},{"key":"key-10.17116\/oftalma20241400517-6","doi-asserted-by":"crossref","unstructured":"Zhang X, Vadoothker S, Munir WM, Saeedi O. Ocular Surface Disease and Glaucoma Medications: A Clinical Approach. Eye Contact Lens. 2019; 45(1):11-18","DOI":"10.1097\/ICL.0000000000000544"},{"key":"key-10.17116\/oftalma20241400517-7","unstructured":"Brzhesky VV. Glaucoma and dry eye syndrome. M.: Borges; 2018:228 (In Russ.)"},{"key":"key-10.17116\/oftalma20241400517-8","unstructured":"Yanchenko SV, Eremenko AI. Peculiarities of morphological status of conjunctiva in patients with POAG after prolonged usage of beta-blockers with conservative and with secondary dry eye syndrome. RMJ. Clinical Ophthalmology = RMZh. Klinicheskaya oftal\u2019mologiya. 2008;9(4):133-135 (In Russ.)"},{"key":"key-10.17116\/oftalma20241400517-9","unstructured":"Eremenko AI, Yanchenko SV, Kiselev AV. Modified impression cytology in patients with secondary dry eye syndrome caused by instillations of eye drops with the presence of a preservative. Kuban Scientific Medical Bulletin = Kubanskiy nauchniy meditsinskiy vestnik. 2009;(9):48-50 (In Russ.)"},{"key":"key-10.17116\/oftalma20241400517-10","unstructured":"Brzhesky VV, Egorova GB, Egorov EA. Dry eye and ocular surface diseases. M.: GEOTAR-Media; 2016:448 (In Russ.)"},{"key":"key-10.17116\/oftalma20241400517-11","doi-asserted-by":"crossref","unstructured":"Olthoff CM, Schouten JS, van de Borne BW, Webers CA. Noncompliance with ocular hypotensive treatment in patients with glaucoma or ocular hypertension an evidence based review. Ophthalmology. 2005;112(6):953-961","DOI":"10.1016\/j.ophtha.2004.12.035"},{"key":"key-10.17116\/oftalma20241400517-12","doi-asserted-by":"publisher","DOI":"10.18008\/1816-5095-2023-4-780-786"},{"key":"key-10.17116\/oftalma20241400517-13","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2017.08.003"},{"key":"key-10.17116\/oftalma20241400517-14","doi-asserted-by":"crossref","unstructured":"Stapleton F, Optom MC, Alves M, Bunya VY, Jalbert I, Lekhanont K, Malet F, Na Kyung-Sun, Schaumberg D, Ushino M, Vehof J, Viso E, Vitale S, Jones L. Optom FC TFOS DEWS II Epidemiology Report. Ocul Surf. 2017;15:334-365","DOI":"10.1016\/j.jtos.2017.05.003"},{"key":"key-10.17116\/oftalma20241400517-15","doi-asserted-by":"publisher","DOI":"10.18008\/1816-5095-2020-2-281-289"},{"key":"key-10.17116\/oftalma20241400517-16","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.10-6997a"},{"key":"key-10.17116\/oftalma20241400517-17","doi-asserted-by":"publisher","DOI":"10.17116\/oftalma202113706155"},{"key":"key-10.17116\/oftalma20241400517-18","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2019-315623"},{"key":"key-10.17116\/oftalma20241400517-19","doi-asserted-by":"publisher","DOI":"10.18008\/1816-5095-2021-2-346-354"},{"key":"key-10.17116\/oftalma20241400517-20","doi-asserted-by":"publisher","DOI":"10.25276\/0235-4160-2016-1-73-77"},{"key":"key-10.17116\/oftalma20241400517-21","doi-asserted-by":"publisher","DOI":"10.1016\/j.chest.2020.03.013"},{"key":"key-10.17116\/oftalma20241400517-22","doi-asserted-by":"publisher","DOI":"10.1089\/sur.2020.469"},{"key":"key-10.17116\/oftalma20241400517-23","doi-asserted-by":"crossref","unstructured":"Korb DR. The tear film \u2014 its role today and in future. In: The Tear Film, structure, function and examination. Butterworth \u2014 Heimann; 2002:254","DOI":"10.1016\/B978-0-7506-4196-8.50009-2"},{"key":"key-10.17116\/oftalma20241400517-24","doi-asserted-by":"publisher","DOI":"10.21516\/2072-0076-2024-17-1-55-61"},{"key":"key-10.17116\/oftalma20241400517-25","doi-asserted-by":"crossref","unstructured":"Bijesterveld OP. Diagnostic tests in the sicca syndrome. Arch Ophthalmol. 1969;82:10-14","DOI":"10.1001\/archopht.1969.00990020012003"},{"key":"key-10.17116\/oftalma20241400517-26","doi-asserted-by":"crossref","unstructured":"Lopez Garsia JS, Garsia Lozano I, Martinez Garchitorena J. Measure of the fatty layer thickness of precorneal tear film by interference colours in different types of dry eye. Arch Soc Esp Oftalmol. 2003;78(5):257-264","DOI":"10.4321\/S0365-66912003000700005"},{"key":"key-10.17116\/oftalma20241400517-27","unstructured":"Loskutov IA, Andryuhina OM, Kovrizhkina AA. Preserve free forms of prostaglandin analogues in the treatment of primary open-angle glaucoma. Effective Pharmacotherapy. Ophthalmology = Effektivnaya farmakoterapiya. Oftal\u2019mologiya. 2022;18(20):16-18 (In Russ.)"},{"key":"key-10.17116\/oftalma20241400517-28","doi-asserted-by":"publisher","DOI":"10.17116\/oftalma202313905136"},{"key":"key-10.17116\/oftalma20241400517-29","doi-asserted-by":"publisher","DOI":"10.18008\/1816-5095-2020-2-281-289"},{"key":"key-10.17116\/oftalma20241400517-30","doi-asserted-by":"publisher","DOI":"10.18008\/181650952016212212"},{"key":"key-10.17116\/oftalma20241400517-31","doi-asserted-by":"crossref","unstructured":"Guillon M, Maissa C, Wong S. Symptomatic relief associated with eyelid hygiene in anterior blepharitis and MGD. Eye Contact Lens. 2012;38(5):306-312","DOI":"10.1097\/ICL.0b013e3182658699"},{"key":"key-10.17116\/oftalma20241400517-32","doi-asserted-by":"publisher","DOI":"10.17116\/oftalma202313901146"},{"key":"key-10.17116\/oftalma20241400517-33","unstructured":"Abisheva LD, Avdeev RV, Alexandrov AS, et al. Optimal characteristics of the upper limit of ophthalmotonus in patients with advanced stage of primary open-angle glaucoma in terms of evidence-based medicine. Clinical Ophthalmology = Klinicheskaya oftal\u2019mologiya. 2015;(3):111-123 (In Russ.)"},{"key":"key-10.17116\/oftalma20241400517-34","unstructured":"Egorov EA, Erichev VP, Kuroedov AS, et al. Indicators of ophthalmotonometry in a healthy population. National Journal glaucoma = Natsional\u2019nyj zhurnal glaukoma. 2018;17(2):91-98 (In Russ.)"},{"key":"key-10.17116\/oftalma20241400517-35","doi-asserted-by":"publisher","DOI":"10.3390\/ijerph18052383"},{"key":"key-10.17116\/oftalma20241400517-36","doi-asserted-by":"publisher","DOI":"10.1111\/aos.15159"},{"key":"key-10.17116\/oftalma20241400517-37","doi-asserted-by":"publisher","DOI":"10.18008\/1816-5095-2023-3-542-548"},{"key":"key-10.17116\/oftalma20241400517-38","doi-asserted-by":"publisher","DOI":"10.1007\/s10103-022-03690-1"},{"key":"key-10.17116\/oftalma20241400517-39","doi-asserted-by":"publisher","DOI":"10.4103\/IJO.IJO_2834_22"},{"key":"key-10.17116\/oftalma20241400517-40","doi-asserted-by":"publisher","DOI":"10.1177\/11206721221127206"}],"container-title":["Russian Annals of Ophthalmology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T08:40:44Z","timestamp":1745397644000},"score":1,"resource":{"primary":{"URL":"https:\/\/mediasphera.ru\/issues\/vestnik-oftalmologii\/2024\/5\/10042465X2024051007"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":40,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2024,11,12]]}},"alternative-id":["10.17116\/oftalma20241400517"],"URL":"https:\/\/doi.org\/10.17116\/oftalma20241400517","relation":{},"ISSN":["0042-465X"],"issn-type":[{"type":"print","value":"0042-465X"}],"subject":[],"published":{"date-parts":[[2024,4,23]]}}}