{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,16]],"date-time":"2026-07-16T21:22:05Z","timestamp":1784236925481,"version":"3.55.0"},"reference-count":12,"publisher":"Media Sphere Publishing House","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. Ann. Ophthal."],"published-print":{"date-parts":[[2024,4,23]]},"abstract":"<jats:p>The introduction of faricimab, a drug targeting both vascular endothelial growth factor-A (VEGF-A) and angiopoietin-2, has enabled the implementation of the highly effective dual inhibition strategy in real clinical practice for patients with neovascular age-related macular degeneration (nAMD) and diabetic macular edema (DME), both previously treated with intravitreal injections and newly diagnosed. This article presents a series of 11 clinical cases involving patients with nAMD and DME who received loading doses of faricimab and continued ophthalmological observation. Among them, three patients with nAMD and two with DME were treatment-na\u00efve, while the others were switched from alternative therapies to faricimab. The duration of follow-up after the loading phase ranged from 4 to 24 weeks at the time of this writing. All patients showed a pronounced anatomical improvement, and seven of the 11 experienced an increase in visual acuity. All reported subjective vision improvement, and no adverse events. These results confirm the high efficacy and safety of faricimab for nAMD and DME, both in treatment-na\u00efve patients and those switched from other therapies.<\/jats:p>","DOI":"10.17116\/oftalma2024140061100","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T05:49:26Z","timestamp":1735364966000},"page":"100","source":"Crossref","is-referenced-by-count":3,"title":["Dual inhibition of VEGF-A and angiopoietin-2 in the treatment of neovascular age-related macular degeneration and diabetic macular edema"],"prefix":"10.17116","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9107-5221","authenticated-orcid":false,"given":"A.V.","family":"Zolotarev","sequence":"first","affiliation":[{"name":"Samara State Medical University","place":["Samara, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4929-8832","authenticated-orcid":false,"given":"E.V.","family":"Karlova","sequence":"additional","affiliation":[{"name":"Samara State Medical University","place":["Samara, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-4408-8873","authenticated-orcid":false,"given":"E.V.","family":"Balandina","sequence":"additional","affiliation":[{"name":"Samara State Medical University","place":["Samara, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.Yu.","family":"Zubkova","sequence":"additional","affiliation":[{"name":"Samara State Medical University","place":["Samara, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-1840-1326","authenticated-orcid":false,"given":"E.E.","family":"Grishina","sequence":"additional","affiliation":[{"name":"Samara State Medical University","place":["Samara, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0258-165X","authenticated-orcid":false,"given":"E.A.","family":"Zamytskiy","sequence":"additional","affiliation":[{"name":"Samara State Medical University","place":["Samara, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0004-6028-7709","authenticated-orcid":false,"given":"N.V.","family":"Balalayeva","sequence":"additional","affiliation":[{"name":"Samara State Medical University","place":["Samara, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6743","reference":[{"key":"key-10.17116\/oftalma2024140061100-1","unstructured":""},{"key":"key-10.17116\/oftalma2024140061100-2","doi-asserted-by":"publisher","DOI":"10.17116\/oftalma202313903246"},{"key":"key-10.17116\/oftalma2024140061100-3","unstructured":""},{"key":"key-10.17116\/oftalma2024140061100-4","doi-asserted-by":"publisher","DOI":"10.15372\/SSMJ20180517"},{"key":"key-10.17116\/oftalma2024140061100-5","doi-asserted-by":"publisher","DOI":"10.1007\/s00417-024-06421-0"},{"key":"key-10.17116\/oftalma2024140061100-6","doi-asserted-by":"publisher","DOI":"10.3390\/life14020193"},{"key":"key-10.17116\/oftalma2024140061100-7","doi-asserted-by":"publisher","DOI":"10.3390\/bioengineering11050478"},{"key":"key-10.17116\/oftalma2024140061100-8","unstructured":""},{"key":"key-10.17116\/oftalma2024140061100-9","doi-asserted-by":"publisher","DOI":"10.25276\/2312-4911-2024-1-279-286"},{"key":"key-10.17116\/oftalma2024140061100-10","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-023-02553-5"},{"key":"key-10.17116\/oftalma2024140061100-11","doi-asserted-by":"publisher","DOI":"10.1186\/s40942-024-00525-9"},{"key":"key-10.17116\/oftalma2024140061100-12","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S463624"}],"container-title":["Russian Annals of Ophthalmology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T08:41:12Z","timestamp":1745397672000},"score":1,"resource":{"primary":{"URL":"https:\/\/mediasphera.ru\/issues\/vestnik-oftalmologii\/2024\/6\/10042465X2024061100"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":12,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12,28]]}},"alternative-id":["10.17116\/oftalma2024140061100"],"URL":"https:\/\/doi.org\/10.17116\/oftalma2024140061100","relation":{},"ISSN":["0042-465X"],"issn-type":[{"value":"0042-465X","type":"print"}],"subject":[],"published":{"date-parts":[[2024,4,23]]}}}