{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T04:09:15Z","timestamp":1745467755650,"version":"3.40.4"},"reference-count":15,"publisher":"Media Sphere Publishing House","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. Ann. Ophthal."],"published-print":{"date-parts":[[2024,4,23]]},"abstract":"<jats:p>Purpose. This study was conducted to identify the group at highest risk for autoimmune inflammation through a comparative analysis among patients with chronic post-traumatic uveitis (CPTU). Material and methods. The clinical group included 50 patients (aged 18 to 87 years, mean age 41\u00b12.6 years) with CPTU resulting from penetrating injury, contusion, or intraocular surgery. All patients underwent comprehensive clinical and diagnostic evaluation, including immunological assessments: leukocyte migration inhibition test (LMIT), analysis of lymphocyte subpopulation composition, and cytokine profile analysis in both blood serum (BS) and aqueous humor (AH). All patients underwent removal of the blind, non-functional eye with formation of a support-motor stump, followed by morphological examination. Patients were divided into four groups based on the presence of immune inflammation, confirmed by morphological analysis, as well as organ-specific sensitization to ocular tissue antigens. Group 1 \u2014 histology+, LMIT+ (n=36); group 2 \u2014 histology+, LMIT\u2013 (n=50); group 3 \u2014 histology\u2013, LMIT+ (n=12); group 4 \u2014 histology\u2013, LMIT\u2013 (n=52). The control group consisted of 30 individuals without ocular pathology, matched by sex and age to the main patient groups. Results. In long-term CPTU, statistically significant alterations in major regulatory subpopulations were observed in group 1, with immune inflammation and a positive LMIT. The findings were confirmed in comparisons with both the control group and across study groups. Conclusion. The clinical and immunomorphological analysis identified an association between decreased levels of transforming growth factor \u03b21 (TGF-\u03b21) in AH and its increased levels in BS, with the risk of autoimmune inflammation in CPTU. The observed changes in the local and systemic cytokine status \u2014 reduction of TGF-\u03b21 in AH and increase in BS \u2014 may serve as early predictors of autoimmune inflammation, which is important in clinical practice for preventing sympathetic ophthalmia.<\/jats:p>","DOI":"10.17116\/oftalma202414006139","type":"journal-article","created":{"date-parts":[[2024,12,28]],"date-time":"2024-12-28T05:49:26Z","timestamp":1735364966000},"page":"39","source":"Crossref","is-referenced-by-count":0,"title":["Results of clinical and immunomorphological analysis in chronic post-traumatic uveitis"],"prefix":"10.17116","volume":"140","author":[{"given":"I.A.","family":"Filatova\u00b9,","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8007-6643","authenticated-orcid":false,"given":"N.V.","family":"Balatskaya","sequence":"additional","affiliation":[{"name":"Helmholtz National Medical Research Center of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1005-5633","authenticated-orcid":false,"given":"I.G.","family":"Kulikova","sequence":"additional","affiliation":[{"name":"Helmholtz National Medical Research Center of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.A.","family":"Shemetov\u00b9,","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1769-2843","authenticated-orcid":false,"given":"V.O.","family":"Denisyuk","sequence":"additional","affiliation":[{"name":"AO Meditsina (Academician Roytberg\u2019s Clinic)","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/oftalma202414006139-1","unstructured":"Arkhipova LT, Gundorova RA, Kuznetsova IA. Pathogenetic treatment of posttraumatic uveitis. Manual for doctors. Moscow: NIIGB named of Helmholtz; 2002 (In Russ.)"},{"key":"key-10.17116\/oftalma202414006139-2","unstructured":"Arkhipova LT. Sympathetic ophthalmia (pathogenesis, pathomorphology, clinic, diagnosis, treatment, prevention). Moscow: Triada; 2006 (In Russ.)"},{"key":"key-10.17116\/oftalma202414006139-3","unstructured":"Arkhipova LT, Gundorova RA, Khvatova AV. Epidemiological features and risk factors of sympathetic ophthalmia. Russian Annals of Ophthalmology=Vestnik oftal\u2019mologii. 1996;(4):12-14 (In Russ.)"},{"key":"key-10.17116\/oftalma202414006139-4","doi-asserted-by":"publisher","DOI":"10.1002\/ccr3.2597"},{"key":"key-10.17116\/oftalma202414006139-5","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1994.01090130090024"},{"key":"key-10.17116\/oftalma202414006139-6","doi-asserted-by":"publisher","DOI":"10.1038\/sj.eye.6702156"},{"key":"key-10.17116\/oftalma202414006139-7","doi-asserted-by":"publisher","DOI":"10.21516\/2072-0076-2021-14-1-15-20"},{"key":"key-10.17116\/oftalma202414006139-8","unstructured":"Maracheva YaM. Immunopathological variants of the course of posttraumatic uveitis with penetrating eyeball injury. Bulletin of the Ural Medical Academic Science. 2012;39(2):42-44 (In Russ.)"},{"key":"key-10.17116\/oftalma202414006139-9","unstructured":"Kulikova IG, Slepova OS, Mironkova EA, et al. The role of (sub)population imbalance of blood lymphocytes in the development of systemic organ-specific sensitization in inflammatory and post-traumatic eye pathology. Russian Ophthalmological Journal. 2013;6(4):71-75 (In Russ.)"},{"key":"key-10.17116\/oftalma202414006139-10","unstructured":"Filatova IA, Beraya MZ, Harb AH. An improved method of removal of the eyeball with cleavage of the sclera. Ophthalmic Surgery. 2007;(2):28-32 (In Russ.)"},{"key":"key-10.17116\/oftalma202414006139-11","doi-asserted-by":"publisher","DOI":"10.1097\/IOP.0000000000000452"},{"key":"key-10.17116\/oftalma202414006139-12","doi-asserted-by":"publisher","DOI":"10.18821\/1993-1859-2017-12-4-210-215"},{"key":"key-10.17116\/oftalma202414006139-13","doi-asserted-by":"publisher","DOI":"10.21516\/2072-0076-2017-10-3-84-92"},{"key":"key-10.17116\/oftalma202414006139-14","unstructured":"Filatova IA, Mohammad IM. RF Patent 2611932 \u201cMethod of eyeball evisceration\u201d. Bul. No. 7. 01.03.2017 (In Russ.)"},{"key":"key-10.17116\/oftalma202414006139-15","unstructured":"Filatova IA, Balatskaya NV, Kulikova IG, Denisyuk VO. RF Patent No. 2754292 \u00abA method for predicting a high risk of autoimmune inflammation in post-traumatic uveitis in the long term\u00bb. Byul. No. 25. 31.08.2021 (In Russ.)"}],"container-title":["Russian Annals of Ophthalmology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T08:40:54Z","timestamp":1745397654000},"score":1,"resource":{"primary":{"URL":"https:\/\/mediasphera.ru\/issues\/vestnik-oftalmologii\/2024\/6\/10042465X2024061039"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,4,23]]},"references-count":15,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12,28]]}},"alternative-id":["10.17116\/oftalma202414006139"],"URL":"https:\/\/doi.org\/10.17116\/oftalma202414006139","relation":{},"ISSN":["0042-465X"],"issn-type":[{"type":"print","value":"0042-465X"}],"subject":[],"published":{"date-parts":[[2024,4,23]]}}}