{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,3,29]],"date-time":"2025-03-29T04:08:52Z","timestamp":1743221332932,"version":"3.40.3"},"reference-count":87,"publisher":"Media Sphere Publishing House","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. Ann. Ophthal."],"published-print":{"date-parts":[[2025,3,6]]},"abstract":"<jats:p>Choroidal neovascularization (CNV) is a pathological angiogenic process observed in various fundus diseases, including choroidal nevi. This article reviews key information on the pathogenesis of CNV associated with choroidal nevi, examines diagnostic methods using optical coherence tomography (OCT) and optical coherence tomography angiography (OCT-A), including modern classifications and criteria for assessing disease activity. The article also discusses approaches to the differential diagnosis of nevi combined with neovascular age-related macular degeneration, progressive nevi, and melanomas, and analyzes the features of treatment with antiangiogenic agents and their effects on pigmented choroidal lesions.<\/jats:p>","DOI":"10.17116\/oftalma2025141011104","type":"journal-article","created":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T09:33:38Z","timestamp":1741253618000},"page":"104","source":"Crossref","is-referenced-by-count":0,"title":["Choroidal neovascularization associated with choroidal nevi"],"prefix":"10.17116","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2226-0594","authenticated-orcid":false,"given":"S.A.","family":"Smolin","sequence":"first","affiliation":[{"name":"Krasnov Research Institute of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4517-0324","authenticated-orcid":false,"given":"A.S.","family":"Stoyukhina","sequence":"additional","affiliation":[{"name":"Krasnov Research Institute of Eye Diseases","place":["Moscow, Russia"]},{"name":"I.M. Sechenov First Moscow State Medical University (Sechenov University)","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/oftalma2025141011104-1","doi-asserted-by":"publisher","DOI":"10.25276\/2312-4911-2020-2-294-297"},{"key":"key-10.17116\/oftalma2025141011104-2","unstructured":"Yannuzzi LA, Friedman R, Fine SL, Gass JD, Gitter KA, Orth DH, Singerman LJ. Symposium on age-related macular degeneration. Bull N Y Acad Med. 1988;64(9):955-1013.  https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/3077076"},{"key":"key-10.17116\/oftalma2025141011104-3","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31823f9b3b"},{"key":"key-10.17116\/oftalma2025141011104-4","doi-asserted-by":"publisher","DOI":"10.5301\/ejo.5000877"},{"key":"key-10.17116\/oftalma2025141011104-5","doi-asserted-by":"publisher","DOI":"10.1364\/OE.20.004710"},{"key":"key-10.17116\/oftalma2025141011104-6","doi-asserted-by":"publisher","DOI":"10.1038\/s41433-019-0415-1"},{"key":"key-10.17116\/oftalma2025141011104-7","doi-asserted-by":"publisher","DOI":"10.17116\/oftalma2023139011138"},{"key":"key-10.17116\/oftalma2025141011104-8","doi-asserted-by":"publisher","DOI":"10.1097\/icb.0b013e31818a46d3"},{"key":"key-10.17116\/oftalma2025141011104-9","doi-asserted-by":"publisher","DOI":"10.17116\/oftalma201513115-11"},{"key":"key-10.17116\/oftalma2025141011104-10","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0b013e31822092b7"},{"key":"key-10.17116\/oftalma2025141011104-11","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2017.04.002"},{"key":"key-10.17116\/oftalma2025141011104-12","doi-asserted-by":"publisher","DOI":"10.2147\/OPTH.S64138"},{"key":"key-10.17116\/oftalma2025141011104-13","doi-asserted-by":"publisher","DOI":"10.1155\/2019\/2672798"},{"key":"key-10.17116\/oftalma2025141011104-14","doi-asserted-by":"publisher","DOI":"10.5693\/djo.02.2013.01.004"},{"key":"key-10.17116\/oftalma2025141011104-15","doi-asserted-by":"publisher","DOI":"10.1016\/j.survophthal.2023.06.002"},{"key":"key-10.17116\/oftalma2025141011104-16","doi-asserted-by":"publisher","DOI":"10.1097\/APO.0000000000000442"},{"key":"key-10.17116\/oftalma2025141011104-17","unstructured":"Nemet A, Zloto O, Segev O, Didi Fabian I, Moroz I, Vishnevskia-Dai V. Small Choroidal Melanoma Associated with Choroidal Neovascularization. Isr Med Assoc J. 2023;25(6):443-444.  https:\/\/www.ncbi.nlm.nih.gov\/pubmed\/37381942"},{"key":"key-10.17116\/oftalma2025141011104-18","doi-asserted-by":"publisher","DOI":"10.1111\/j.1600-0420.2005.00630.x"},{"key":"key-10.17116\/oftalma2025141011104-19","doi-asserted-by":"publisher","DOI":"10.1016\/j.oret.2021.12.015"},{"key":"key-10.17116\/oftalma2025141011104-20","doi-asserted-by":"crossref","unstructured":"Brown GC, Shields JA, Augsburger JJ. Amelanotic choroidal nevi. Ophthalmology. 1981;88(11):1116-1121","DOI":"10.1016\/S0161-6420(81)34896-9"},{"key":"key-10.17116\/oftalma2025141011104-21","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2007.07.009"},{"key":"key-10.17116\/oftalma2025141011104-22","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(77)90726-7"},{"key":"key-10.17116\/oftalma2025141011104-23","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1997.01100160707007"},{"key":"key-10.17116\/oftalma2025141011104-24","doi-asserted-by":"publisher","DOI":"10.1016\/S0008-4182(04)80005-X"},{"key":"key-10.17116\/oftalma2025141011104-25","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(03)00868-7"},{"key":"key-10.17116\/oftalma2025141011104-26","doi-asserted-by":"publisher","DOI":"10.1001\/archophthalmol.2009.151"},{"key":"key-10.17116\/oftalma2025141011104-27","doi-asserted-by":"publisher","DOI":"10.1097\/ICU.0000000000000560"},{"key":"key-10.17116\/oftalma2025141011104-28","unstructured":"Pastore S, Zeiger JS, Negretti GS, Shields CL. Hemorrhage Over a Choroidal Nevus\u2014Harmless or Hazardous? Retin Today. 2022;2022(October):52-53"},{"key":"key-10.17116\/oftalma2025141011104-29","unstructured":"Snip RC, Green WR, Jaegers KR. Choroidal nevus with subretinal pigment epithelial neovascular membrane and a positive P-32 test. Ophthalmic Surg. 1978;9(5):35-42"},{"key":"key-10.17116\/oftalma2025141011104-30","doi-asserted-by":"publisher","DOI":"10.1177\/112067210401400207"},{"key":"key-10.17116\/oftalma2025141011104-31","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000001730"},{"key":"key-10.17116\/oftalma2025141011104-32","doi-asserted-by":"publisher","DOI":"10.1016\/S0002-9394(14)77109-0"},{"key":"key-10.17116\/oftalma2025141011104-33","doi-asserted-by":"publisher","DOI":"10.1177\/1120672119851768"},{"key":"key-10.17116\/oftalma2025141011104-34","doi-asserted-by":"publisher","DOI":"10.1016\/0002-9394(67)90031-1"},{"key":"key-10.17116\/oftalma2025141011104-35","doi-asserted-by":"publisher","DOI":"10.3390\/ijms24021064"},{"key":"key-10.17116\/oftalma2025141011104-36","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1993.01090060077026"},{"key":"key-10.17116\/oftalma2025141011104-37","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.1978.03910050212003"},{"key":"key-10.17116\/oftalma2025141011104-38","doi-asserted-by":"publisher","DOI":"10.1111\/j.1755-3768.1982.tb03032.x"},{"key":"key-10.17116\/oftalma2025141011104-39","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(89)32859-4"},{"key":"key-10.17116\/oftalma2025141011104-40","doi-asserted-by":"publisher","DOI":"10.1055\/s-2008-1046005"},{"key":"key-10.17116\/oftalma2025141011104-41","unstructured":"Ziangirova GG, Likhvantseva VG. Tumors of the vascular tract of the eye. Moscow; 2003 (In Russ.)"},{"key":"key-10.17116\/oftalma2025141011104-42","unstructured":"Shepkalova VM, Xorasanyan-Tade` AA, Disler ON. Intraocular tumors. Atlas. Moscow: Medicina; 1965 (In Russ.)"},{"key":"key-10.17116\/oftalma2025141011104-43","doi-asserted-by":"publisher","DOI":"10.17116\/oftalma202113702118"},{"key":"key-10.17116\/oftalma2025141011104-44","doi-asserted-by":"publisher","DOI":"10.1016\/j.acthis.2021.151842"},{"key":"key-10.17116\/oftalma2025141011104-45","doi-asserted-by":"publisher","DOI":"10.17116\/oftalma2020136042354"},{"key":"key-10.17116\/oftalma2025141011104-46","unstructured":"Shields JA. Diagnosis and Management of Intraocular Tumor. St. Louis: The C.V. Mosby Company; 1983"},{"key":"key-10.17116\/oftalma2025141011104-47","doi-asserted-by":"publisher","DOI":"10.24292\/01.OT.311222.5"},{"key":"key-10.17116\/oftalma2025141011104-48","doi-asserted-by":"publisher","DOI":"10.1159\/000458516"},{"key":"key-10.17116\/oftalma2025141011104-49","doi-asserted-by":"publisher","DOI":"10.3928\/23258160-20180501-10"},{"key":"key-10.17116\/oftalma2025141011104-50","doi-asserted-by":"publisher","DOI":"10.1038\/eye.1997.57"},{"key":"key-10.17116\/oftalma2025141011104-51","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(94)31273-5"},{"key":"key-10.17116\/oftalma2025141011104-52","doi-asserted-by":"publisher","DOI":"10.21516\/2072-0076-2021-14-3-40-45"},{"key":"key-10.17116\/oftalma2025141011104-53","doi-asserted-by":"publisher","DOI":"10.18008\/1816-5095-2020-2-172-180"},{"key":"key-10.17116\/oftalma2025141011104-54","unstructured":"Stoyukhina AS, Smolin SA. Differential diagnosis of nevi and melanomas of the choroid according to OCT. Sovremenny\u2019e tehnologii v oftal\u2019mologii. 2024;(1):306-316 (In Russ.)"},{"key":"key-10.17116\/oftalma2025141011104-55","doi-asserted-by":"publisher","DOI":"10.4103\/0301-4738.154373"},{"key":"key-10.17116\/oftalma2025141011104-56","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2019-314755"},{"key":"key-10.17116\/oftalma2025141011104-57","doi-asserted-by":"publisher","DOI":"10.1097\/IAE.0000000000002440"},{"key":"key-10.17116\/oftalma2025141011104-58","doi-asserted-by":"publisher","DOI":"10.4103\/0974-620X.192288"},{"key":"key-10.17116\/oftalma2025141011104-59","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2015.06.008"},{"key":"key-10.17116\/oftalma2025141011104-60","doi-asserted-by":"publisher","DOI":"10.1001\/archopht.116.5.645"},{"key":"key-10.17116\/oftalma2025141011104-61","doi-asserted-by":"publisher","DOI":"10.1016\/S0161-6420(82)34711-9"},{"key":"key-10.17116\/oftalma2025141011104-62","doi-asserted-by":"publisher","DOI":"10.18008\/1816-5095-2022-2-368-377"},{"key":"key-10.17116\/oftalma2025141011104-63","doi-asserted-by":"publisher","DOI":"10.22363\/2313-0245-2021-25-2-106-113"},{"key":"key-10.17116\/oftalma2025141011104-64","doi-asserted-by":"publisher","DOI":"10.3389\/fonc.2021.714646"},{"key":"key-10.17116\/oftalma2025141011104-65","doi-asserted-by":"publisher","DOI":"10.3980\/j.issn.2222-3959.2011.01.11"},{"key":"key-10.17116\/oftalma2025141011104-66","doi-asserted-by":"publisher","DOI":"10.1007\/s12094-021-02597-7"},{"key":"key-10.17116\/oftalma2025141011104-67","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.6868"},{"key":"key-10.17116\/oftalma2025141011104-68","doi-asserted-by":"publisher","DOI":"10.1073\/pnas.90.4.1526"},{"key":"key-10.17116\/oftalma2025141011104-69","doi-asserted-by":"publisher","DOI":"10.2147\/DDDT.S97653"},{"key":"key-10.17116\/oftalma2025141011104-70","doi-asserted-by":"publisher","DOI":"10.1155\/2015\/892043"},{"key":"key-10.17116\/oftalma2025141011104-71","doi-asserted-by":"publisher","DOI":"10.25276\/2686-6986-2022-2-27-30"},{"key":"key-10.17116\/oftalma2025141011104-72","doi-asserted-by":"publisher","DOI":"10.7554\/eLife.83527"},{"key":"key-10.17116\/oftalma2025141011104-73","doi-asserted-by":"publisher","DOI":"10.3390\/cancers9040035"},{"key":"key-10.17116\/oftalma2025141011104-74","doi-asserted-by":"publisher","DOI":"10.15789\/1563-0625-PMO-2180"},{"key":"key-10.17116\/oftalma2025141011104-75","doi-asserted-by":"publisher","DOI":"10.1016\/j.ccr.2009.01.027"},{"key":"key-10.17116\/oftalma2025141011104-76","unstructured":"El Filali M, Ly L V, Luyten GPM, Versluis M, Grossniklaus HE, van der Velden PA, Jager MJ. Bevacizumab and intraocular tumors: an intriguing paradox. Mol Vis. 2012;18:2454-2467"},{"key":"key-10.17116\/oftalma2025141011104-77","doi-asserted-by":"publisher","DOI":"10.1007\/s10456-014-9420-y"},{"key":"key-10.17116\/oftalma2025141011104-78","doi-asserted-by":"publisher","DOI":"10.18008\/1816-5095-2021-3S-638-645"},{"key":"key-10.17116\/oftalma2025141011104-79","doi-asserted-by":"publisher","DOI":"10.17116\/oftalma2018134061107"},{"key":"key-10.17116\/oftalma2025141011104-80","doi-asserted-by":"publisher","DOI":"10.17116\/oftalma202213804158"},{"key":"key-10.17116\/oftalma2025141011104-81","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2013-303234"},{"key":"key-10.17116\/oftalma2025141011104-82","doi-asserted-by":"publisher","DOI":"10.1097\/MD.0000000000009400"},{"key":"key-10.17116\/oftalma2025141011104-83","doi-asserted-by":"publisher","DOI":"10.1186\/s12886-019-1108-z"},{"key":"key-10.17116\/oftalma2025141011104-84","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajo.2010.08.040"},{"key":"key-10.17116\/oftalma2025141011104-85","doi-asserted-by":"publisher","DOI":"10.1159\/000450859"},{"key":"key-10.17116\/oftalma2025141011104-86","doi-asserted-by":"publisher","DOI":"10.1159\/000329591"},{"key":"key-10.17116\/oftalma2025141011104-87","doi-asserted-by":"publisher","DOI":"10.3332\/ecancer.2013.336"}],"container-title":["Russian Annals of Ophthalmology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,3,28]],"date-time":"2025-03-28T08:44:40Z","timestamp":1743151480000},"score":1,"resource":{"primary":{"URL":"https:\/\/mediasphera.ru\/issues\/vestnik-oftalmologii\/2025\/1\/10042465X2025011104"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3,6]]},"references-count":87,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2025,3,6]]}},"alternative-id":["10.17116\/oftalma2025141011104"],"URL":"https:\/\/doi.org\/10.17116\/oftalma2025141011104","relation":{},"ISSN":["0042-465X"],"issn-type":[{"type":"print","value":"0042-465X"}],"subject":[],"published":{"date-parts":[[2025,3,6]]}}}