{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,23]],"date-time":"2025-12-23T15:35:36Z","timestamp":1766504136346,"version":"3.40.5"},"reference-count":15,"publisher":"Media Sphere Publishing House","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. Ann. Ophthal."],"published-print":{"date-parts":[[2025,5,12]]},"abstract":"<jats:p>Salzmann\u2019s nodular degeneration (SND) is a condition characterized by superficial subepithelial fibrosis of the cornea. Surgical treatment of SND usually consists of manual keratectomy of fibrotic nodules. When stromal layers of the optical zone are involved in the pathologic process, more technically complicated approaches may be preferred. Purpose. This study evaluated the effectiveness of surgical treatment of central corneal opacities in SND. Material and methods. The study analyzed surgical treatment outcomes of 61 eyes in 46 patients following the removal of centrally located fibrous nodules in the anterior stromal layers. Patients were divided into two groups based on the depth of stromal involvement. Patients of group 1 had stromal lesion depth up to 70 \u03bcm and underwent either phototherapeutic keratectomy (PTK) (subgroup 1a \u2014 22 eyes) or automated microkeratome-assisted keratectomy (subgroup 1b \u2014 13 eyes). Group 2 included patients with the depth of stromal layers lesion more than 70 \u03bcm, they underwent automated anterior lamellar keratoplasty (ALK) using a microkeratome head of either 130 \u03bcm (subgroup 2a \u2014 14 eyes) or 200 \u03bcm (subgroup 2b \u2014 12 eyes). Results. In group 1, both methods of keratectomy significantly improved visual acuity. Postoperative sphere-equivalent (SE), astigmatism and keratometry values showed no significant differences between PTK and automated keratectomy. Rate of epithelialization was significantly higher after PTK. In group 2, postoperative visual acuity, SE, astigmatism and keratometry readings had no statistically significant differences between the subgroups. ALK performed using a 200 \u03bcm head with graft fixation by continuous suture resulted in a smaller variation of astigmatism values. All patients were prescribed Stillavit or Stillavit Intensiv, which promoted rapid recovery of corneal epithelium. Conclusion. Both keratectomy techniques can be effectively used in clinical practice depending on equipment availability. Although ALK with a 200-\u03bcm microkeratome head demonstrated more predictable outcomes, further improvement of thin-flap techniques will be beneficial.<\/jats:p>","DOI":"10.17116\/oftalma202514102175","type":"journal-article","created":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T11:58:44Z","timestamp":1747051124000},"page":"75","source":"Crossref","is-referenced-by-count":1,"title":["Surgical treatment of central corneal opacities in Salzmann\u2019s degeneration"],"prefix":"10.17116","volume":"141","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4360-793X","authenticated-orcid":false,"given":"S.V.","family":"Trufanov","sequence":"first","affiliation":[{"name":"Nashe Zdorovye Clinic","place":["Saint Petersburg, Russia"]},{"name":"Fact Clinic","place":["Pyatigorsk, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5187-1047","authenticated-orcid":false,"given":"I.A.","family":"Riks","sequence":"additional","affiliation":[{"name":"Nashe Zdorovye Clinic","place":["Saint Petersburg, Russia"]},{"name":"Fact Clinic","place":["Pyatigorsk, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/oftalma202514102175-1","doi-asserted-by":"publisher","DOI":"10.18008\/1816-5095-2022-3-482-488"},{"key":"key-10.17116\/oftalma202514102175-2","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2021.11.009"},{"key":"key-10.17116\/oftalma202514102175-3","doi-asserted-by":"publisher","DOI":"10.17116\/oftalma202414006180"},{"key":"key-10.17116\/oftalma202514102175-4","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e3181b7658d"},{"key":"key-10.17116\/oftalma202514102175-5","doi-asserted-by":"publisher","DOI":"10.1016\/j.jtos.2015.08.006"},{"key":"key-10.17116\/oftalma202514102175-6","doi-asserted-by":"publisher","DOI":"10.3928\/1081-597X-20010701-10"},{"key":"key-10.17116\/oftalma202514102175-7","doi-asserted-by":"publisher","DOI":"10.1097\/01.ico.0000153100.74033.ef"},{"key":"key-10.17116\/oftalma202514102175-8","doi-asserted-by":"publisher","DOI":"10.1016\/j.clae.2011.02.004"},{"key":"key-10.17116\/oftalma202514102175-9","doi-asserted-by":"publisher","DOI":"10.1007\/BF00935715"},{"key":"key-10.17116\/oftalma202514102175-10","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0b013e31815a50fb"},{"key":"key-10.17116\/oftalma202514102175-11","doi-asserted-by":"publisher","DOI":"10.1167\/iovs.13-12547"},{"key":"key-10.17116\/oftalma202514102175-12","doi-asserted-by":"publisher","DOI":"10.1097\/ICO.0000000000000816"},{"key":"key-10.17116\/oftalma202514102175-13","doi-asserted-by":"publisher","DOI":"10.1055\/a-1788-3819"},{"key":"key-10.17116\/oftalma202514102175-14","doi-asserted-by":"publisher","DOI":"10.1097\/ICL.0b013e318243e813"},{"key":"key-10.17116\/oftalma202514102175-15","doi-asserted-by":"publisher","DOI":"10.21689\/2311-7729-2018-18-1-1-6"}],"container-title":["Russian Annals of Ophthalmology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,5,12]],"date-time":"2025-05-12T11:59:07Z","timestamp":1747051147000},"score":1,"resource":{"primary":{"URL":"https:\/\/mediasphera.ru\/issues\/vestnik-oftalmologii\/2025\/2\/10042465X2025021075"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5,12]]},"references-count":15,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2025,5,12]]}},"alternative-id":["10.17116\/oftalma202514102175"],"URL":"https:\/\/doi.org\/10.17116\/oftalma202514102175","relation":{},"ISSN":["0042-465X"],"issn-type":[{"value":"0042-465X","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5,12]]}}}