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Neurofilament (NF) expression was assessed immunohistochemically using the Neurofilament NE-14 antibody and quantified with ImageJ 1.54i. Statistical analysis included Pearson and Spearman correlation coefficients, as well as the Kruskal\u2014Wallis, Mann\u2014Whitney, and Kendall\u2019s tau tests. Results. The ratio of connective tissue to neural components in the LC varied and correlated with age (\u03c7\u00b2=21.09, p=0.0018). Based on these differences, three LC patterns were identified: mixed, elastic, and collagenous. The mixed LC pattern was most prevalent across all age groups; the elastic pattern predominated in younger individuals (&lt;44 years); the collagenous pattern was most common in individuals older than 60 years. NF expression was lowest in the mixed type LC, increased significantly in the elastic type LC, and was highest in the &gt;60-year age group with the collagenous type LC. Conclusion. Remodelling of the LC of the sclera characterized by a predominance of collagenous tissue, primarily perivascularly, and accompanied by deformation of the anterior LC surface in individuals older than 60 years, together with a tendency toward increased deviation of ON axons passing through the LC, should be considered potential risk factors for ON axonal injury. The observed variability in the NF cytoskeleton, which preceded changes in axonal transport, may be used as an early marker of retinal ganglion cell damage.<\/jats:p>","DOI":"10.17116\/oftalma202614201160","type":"journal-article","created":{"date-parts":[[2026,3,18]],"date-time":"2026-03-18T09:17:32Z","timestamp":1773825452000},"page":"60","source":"Crossref","is-referenced-by-count":0,"title":["Remodelling of the lamina cribrosa of the sclera in optic nerve axonal injury"],"prefix":"10.17116","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0756-8999","authenticated-orcid":false,"given":"Yu.A.","family":"Huseva","sequence":"first","affiliation":[{"name":"Eye Microsurgery Centre VOKA","place":["Minsk, Belarus"]},{"name":"Belarusian State Medical University","place":["Minsk, Belarus"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0001-9603-7785","authenticated-orcid":false,"given":"M.I.","family":"Pazniak","sequence":"additional","affiliation":[{"name":"Eye Microsurgery Centre VOKA","place":["Minsk, Belarus"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/oftalma202614201160-1","unstructured":"Volkov VV. 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