{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T01:01:38Z","timestamp":1777510898711,"version":"3.51.4"},"reference-count":9,"publisher":"Media Sphere Publishing House","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. Ann. Ophthal."],"published-print":{"date-parts":[[2026,4,28]]},"abstract":"<jats:p>Radioactive iodine (I-131) therapy for differentiated thyroid cancer is associated with a risk of delayed complications affecting radiosensitive organs. One such complication is secondary obstruction of the lacrimal drainage system caused by accumulation of I-131 in the wall of the nasolacrimal duct, leading to chronic inflammation and fibrosis. However, the precise chronological pattern of this pathology\u2019s onset remains undefined. Purpose. This study investigated the chronological patterns of lacrimal drainage obstruction following radioactive iodine therapy. Material and Methods. This retrospective survey involved 375 patients who underwent a single course of radioactive iodine therapy between 2021 and 2025. The patients were stratified into five groups according to the time interval between therapy and survey: \u22646; 7\u201412; 13\u201424; 25\u201436; and 37\u201451 months. Obstruction was defined as epiphora graded 3\u20144 on the Munk scale. Statistical analysis included Pearson\u2019s \u03c7\u00b2 test, Fisher\u2019s exact test, and linear trend analysis (p&lt;0.05 was considered significant). Results. No cases of lacrimal drainage obstruction were identified within the first 6 months after therapy, then the frequency of complications increased progressively: 6.3% (7\u201412 months), 11.3% (13\u201424 months), and 13.6% (25\u201436 months), followed by a decrease to 7.5% (37\u201451 months). The association with time since radioactive iodine therapy was statistically significant (p=0.014; p=0.002). After 6 months, the association lost statistical significance (p=0.455), indicating risk stabilization. The probability of obstruction was significantly higher in men (\u03c7\u00b2=5.637; p=0.018). The administered activity of I-131 had no statistically significant impact. Conclusion. Lacrimal drainage obstruction is a delayed complication of radioactive iodine therapy for differentiated thyroid cancer, with a peak incidence at 25\u201436 months after treatment. The critical screening period is 6\u201451 months post-therapy. Early diagnosis and timely referral to an ophthalmologist improve the effectiveness of minimally invasive interventions.<\/jats:p>","DOI":"10.17116\/oftalma202614202134","type":"journal-article","created":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:38:39Z","timestamp":1777390719000},"page":"34","source":"Crossref","is-referenced-by-count":0,"title":["Chronological patterns of lacrimal drainage obstruction following radioactive iodine therapy for differentiated thyroid cancer"],"prefix":"10.17116","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2990-8111","authenticated-orcid":false,"given":"V.D.","family":"Yartsev","sequence":"first","affiliation":[{"name":"Krasnov Research Institute of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9875-6217","authenticated-orcid":false,"given":"E.L.","family":"Atkova","sequence":"additional","affiliation":[{"name":"Krasnov Research Institute of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-0429-662X","authenticated-orcid":false,"given":"E.A.","family":"Ushakov","sequence":"additional","affiliation":[{"name":"Krasnov Research Institute of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5592-4727","authenticated-orcid":false,"given":"A.A.","family":"Trukhin","sequence":"additional","affiliation":[{"name":"National Medical Research Center of Endokrinology","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9708-0470","authenticated-orcid":false,"given":"D.V.","family":"Yudakov","sequence":"additional","affiliation":[{"name":"National Medical Research Center of Endokrinology","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1326-1069","authenticated-orcid":false,"given":"S.V.","family":"Grishkov","sequence":"additional","affiliation":[{"name":"Russian University of Medicine","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3785-0335","authenticated-orcid":false,"given":"M.S.","family":"Sheremeta","sequence":"additional","affiliation":[{"name":"National Medical Research Center of Endokrinology","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-9362-0128","authenticated-orcid":false,"given":"M.A.","family":"Efremenko","sequence":"additional","affiliation":[{"name":"Krasnov Research Institute of Eye Diseases","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0009-7926-7253","authenticated-orcid":false,"given":"P.N.","family":"Ilina","sequence":"additional","affiliation":[{"name":"Krasnov Research Institute of Eye Diseases","place":["Moscow, Russia"]},{"name":"RUDN University","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/oftalma202614202134-1","doi-asserted-by":"publisher","DOI":"10.1080\/02713683.2021.1878229"},{"key":"key-10.17116\/oftalma202614202134-2","doi-asserted-by":"publisher","DOI":"10.1097\/iop.0000000000001521"},{"key":"key-10.17116\/oftalma202614202134-3","doi-asserted-by":"publisher","DOI":"10.1016\/j.ajoc.2022.101344"},{"key":"key-10.17116\/oftalma202614202134-4","doi-asserted-by":"publisher","DOI":"10.2217\/fon.10.127"},{"key":"key-10.17116\/oftalma202614202134-5","doi-asserted-by":"publisher","DOI":"10.1002\/hed.26741"},{"key":"key-10.17116\/oftalma202614202134-6","doi-asserted-by":"publisher","DOI":"10.1111\/j.1601-0825.2010.01726.x"},{"key":"key-10.17116\/oftalma202614202134-7","doi-asserted-by":"publisher","DOI":"10.4158\/ep10170.ra"},{"key":"key-10.17116\/oftalma202614202134-8","doi-asserted-by":"publisher","DOI":"10.1097\/01.rlu.0000170013.84378.2a"},{"key":"key-10.17116\/oftalma202614202134-9","doi-asserted-by":"publisher","DOI":"10.14341\/probl13163"}],"container-title":["Russian Annals of Ophthalmology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,4,28]],"date-time":"2026-04-28T15:38:48Z","timestamp":1777390728000},"score":1,"resource":{"primary":{"URL":"https:\/\/mediasphera.ru\/issues\/vestnik-oftalmologii\/2026\/2\/10042465X2026021034"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,28]]},"references-count":9,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4,28]]}},"alternative-id":["10.17116\/oftalma202614202134"],"URL":"https:\/\/doi.org\/10.17116\/oftalma202614202134","relation":{},"ISSN":["0042-465X"],"issn-type":[{"value":"0042-465X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,4,28]]}}}