{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T06:46:12Z","timestamp":1782715572934,"version":"3.54.5"},"reference-count":10,"publisher":"Media Sphere Publishing House","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. Ann. Ophthal."],"published-print":{"date-parts":[[2026,6,29]]},"abstract":"<jats:p>High myopia is one of the main causes of reversible vision loss worldwide among the working-age population. Despite the widespread use of phakic intraocular lenses (PIOLs) for correction, immunological changes in the aqueous humor before and after implantation remain insufficiently studied. Objective. The study aimed to assess and compare cytokine levels in the aqueous humor before and after implantation of collamer-based and acrylic-based PIOLs in patients with high myopia. Material and methods. The study included 58 patients (103 eyes) with high myopia scheduled for PIOL implantation. The main group (A) consisted of 36 patients (68 eyes) who received collamer-based PIOLs. The comparison group (B) comprised 22 patients (35 eyes) who received acrylic-based PIOLs. The control group included 20 patients (20 eyes) with emmetropia. Cytokine levels of IL-6, TNF-\u03b1, and TGF-\u03b22 were studied only in 18 patients (30 eyes) using solid-phase enzyme-linked immunosorbent assay with special reagents. Results. After implantation of different types of PIOLs, all patients included in the study achieved the desired outcome: residual refractive error (0.75\u00b10.5 D) and visual acuity (0.85\u00b10.17) remained stable during the 24-month postoperative period. Before PIOL implantation, patients with high myopia showed a statistically significant increase in IL-6 concentration \u2014 more than 2.5-fold (9.51\u00b10.52 pg\/ml vs 3.82\u00b10.26 pg\/ml in the control group) (p&lt;0.001). The TNF-\u03b1 level increased almost 1.8-fold (9.98\u00b10.53 pg\/ml vs 5.63\u00b10.42 pg\/ml in the control group) (p&lt;0.001). In the main group, the TGF-\u03b22 level was 15.99\u00b11.09 pg\/ml, which was 4.1- times higher than the control values (3.88\u00b10.26 pg\/ml) (p&lt;0.001). Conclusion. PIOL implantation in high myopia is an effective, safe, and reliable correction method associated with marked changes in the local cytokine profile. Collamer lenses induce a less intense inflammatory response and a more active remodeling reaction compared with acrylic lenses.<\/jats:p>","DOI":"10.17116\/oftalma202614203138","type":"journal-article","created":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T06:05:27Z","timestamp":1782713127000},"page":"38","source":"Crossref","is-referenced-by-count":0,"title":["Evaluation of the inflammatory response after implantation of different types of phakic intraocular lenses in high myopia"],"prefix":"10.17116","volume":"142","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6551-3155","authenticated-orcid":false,"given":"Z.S.","family":"Kamalov","sequence":"first","affiliation":[{"name":"Institute of Human Immunology and Genomics of the Academy of Sciences of the Republic of Uzbekistan","place":["Tashkent, Republic of Uzbekistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7250-8159","authenticated-orcid":false,"given":"Kh.M.","family":"Kamilov","sequence":"additional","affiliation":[{"name":"Center for the Development of Professional Qualifications of Medical Workers","place":["Tashkent, Republic of Uzbekistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4462-5091","authenticated-orcid":false,"given":"A.F.","family":"Yusupov","sequence":"additional","affiliation":[{"name":"Republican Specialized Scientific and Practical Medical Center for Eye Microsurgery","place":["Tashkent, Republic of Uzbekistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3380-522X","authenticated-orcid":false,"given":"N.N.","family":"Zaynutdinov","sequence":"additional","affiliation":[{"name":"Republican Specialized Scientific and Practical Medical Center for Eye Microsurgery","place":["Tashkent, Republic of Uzbekistan"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6743","reference":[{"key":"key-10.17116\/oftalma202614203138-1","doi-asserted-by":"publisher","DOI":"10.1016\/j.ophtha.2016.01.006"},{"key":"key-10.17116\/oftalma202614203138-2","doi-asserted-by":"publisher","DOI":"10.1136\/bjophthalmol-2017-311266"},{"key":"key-10.17116\/oftalma202614203138-3","doi-asserted-by":"publisher","DOI":"10.1155\/2014\/923691"},{"key":"key-10.17116\/oftalma202614203138-4","doi-asserted-by":"publisher","DOI":"10.1097\/00007890-199906270-00001"},{"key":"key-10.17116\/oftalma202614203138-5","doi-asserted-by":"publisher","DOI":"10.17691\/stm2015.7.3.20"},{"key":"key-10.17116\/oftalma202614203138-6","unstructured":"Sozurakova EA, Gromakina EV, Shabaldin AV, Shternis TA, Sedova DYu, Tretyak EA, Shchigaryova SO. Evaluation of the role of immunoregulatory potential in limiting local inflammation in the anterior chamber of the eye (using presenile cataract as an example). Sovremennye problemy nauki i obrazovaniya. 2019;2. (In Russ.). https:\/\/science-education.ru\/ru\/article\/view?id =28677"},{"key":"key-10.17116\/oftalma202614203138-7","doi-asserted-by":"publisher","DOI":"10.25276\/978-5-903624-36-2-444-458"},{"key":"key-10.17116\/oftalma202614203138-8","unstructured":"Dohlman TH, Dana R, Sadrai Z. Corneal immune privilege: pathogenesis and clinical relevance. J Immunol. 2021;207(2):234-241"},{"key":"key-10.17116\/oftalma202614203138-9","doi-asserted-by":"publisher","DOI":"10.1172\/JCI42440"},{"key":"key-10.17116\/oftalma202614203138-10","unstructured":"Zhang JS, Da Wang J, Zhu GY, et al. The expression of cytokines in aqueous humor of high myopic patients with cataracts. Mol Vis. 2020 Mar 05; 26:150-157"}],"container-title":["Russian Annals of Ophthalmology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T06:06:20Z","timestamp":1782713180000},"score":1,"resource":{"primary":{"URL":"https:\/\/mediasphera.ru\/issues\/vestnik-oftalmologii\/2026\/3\/10042465X2026031038"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,6,29]]},"references-count":10,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,6,29]]}},"alternative-id":["10.17116\/oftalma202614203138"],"URL":"https:\/\/doi.org\/10.17116\/oftalma202614203138","relation":{},"ISSN":["0042-465X"],"issn-type":[{"value":"0042-465X","type":"print"}],"subject":[],"published":{"date-parts":[[2026,6,29]]}}}