{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,16]],"date-time":"2025-05-16T18:43:01Z","timestamp":1747420981290,"version":"3.40.5"},"reference-count":20,"publisher":"Media Sphere Publishing House","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. J. Arch. Pathol."],"published-print":{"date-parts":[[2023,4,23]]},"abstract":"<jats:p>\u2014 \u2014 \u2014 \u2014 \u2014 \u2014 \u2014 \u2014 \u2014 \u2014 \u2014 \u2014 \u2014 \u2014 \u2014 \u2014 \u2014 \u2014 Background. Malignant neoplasms of the kidneys are among the 10 most common oncological diseases in Russia, in which various kidney lesions can occur, including glomerulopathy. Glomerular pathology can be an independent nosology, a manifestation of paraneoplastic syndrome or metabolic disturbances. Objective. Evaluation of the incidence and structure of glomerulopathies in patients with kidney neoplasms. Material and methods. We analyzed 141 samples with a tumor obtained during nephrectomy. To diagnose glomerular pathology, a fragment of the kidney parenchyma was examined at a distance of at least 4 cm from the tumor border. Histological slides were stained with hematoxylin and eosin, methenamine silver, trichrome Masson, Congo red, PAS reaction was performed. Immunofluorescent microscopy was performed with antibodies to IgA, IgG, IgM, C3c, C1q, Kappa light chain and Lambda light chain. Samples for electron microscopy were contrasted with a solution of 0.1% lead citrate. Results. Malignant neoplasms were diagnosed in 130 (92.2%) patients, benign ones \u2014 in 11 (7.8%) patients. In 59 patients with kidney tumors, glomerulopathies were detected, which amounted to 41.8%. All cases of glomerulopathies were diagnosed in combination with carcinomas of the kidneys and renal pelvis. Among 59 cases of glomerulopathy, diabetic nephropathy was diagnosed in 44 (74.6%) cases, IgA nephropathy \u2014 in 7 (11.9%) cases, membranous nephropathy \u2014 in 1 (1.6%), minimal change disease \u2014 in 2 (3.4%), focal segmental glomerulosclerosis \u2014 in 5 (8.5%). Conclusion. The study demonstrates a high incidence of glomerulopathies in patients with malignant kidney tumors. The performed work emphasizes the importance of an in-depth morphological study of the kidneys in the presence of a tumor with an integrated approach to the treatment of patients.<\/jats:p>","DOI":"10.17116\/patol20238502121","type":"journal-article","created":{"date-parts":[[2023,4,13]],"date-time":"2023-04-13T18:11:59Z","timestamp":1681409519000},"page":"21","source":"Crossref","is-referenced-by-count":2,"title":["Glomerulopathy in kidney neoplasms: frequency of occurrence, structure of morbidity"],"prefix":"10.17116","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3343-6973","authenticated-orcid":false,"given":"T.A.","family":"Garkusha","sequence":"first","affiliation":[{"name":"Krasnoyarsk Regional Pathoanatomical Bureau","place":["Krasnoyarsk, Russia"]},{"name":"V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University","place":["Krasnoyarsk, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0402-8348","authenticated-orcid":false,"given":"E.S.","family":"Stolyarevich","sequence":"additional","affiliation":[{"name":"A.I. Yevdokimov Moscow State University of Medicine and Dentistry","place":["Moscow, Russia"]},{"name":"City Clinical Hospital No. 52","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9196-7246","authenticated-orcid":false,"given":"V.A.","family":"Khorzhevskii","sequence":"additional","affiliation":[{"name":"Krasnoyarsk Regional Pathoanatomical Bureau","place":["Krasnoyarsk, Russia"]},{"name":"V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University","place":["Krasnoyarsk, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0606-872X","authenticated-orcid":false,"given":"S.V.","family":"Ivliev","sequence":"additional","affiliation":[{"name":"V.F. Voyno-Yasenetsky Krasnoyarsk State Medical University","place":["Krasnoyarsk, Russia"]},{"name":"Regional Clinical Hospital","place":["Krasnoyarsk, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/patol20238502121-1","unstructured":"Kaprin AD, Starinskii VV, Shakhzadova AO, eds. Malignant neoplasms in Russia in 2019 (incidence and mortality). M.: P.A. Hertsen Moscow Oncology Research Institute \u2014 branch of the National Medical Research Radiological Centre of the Ministry of Health of the Russian Federation; 2020. 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