{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,29]],"date-time":"2026-03-29T14:29:08Z","timestamp":1774794548499,"version":"3.50.1"},"reference-count":16,"publisher":"Media Sphere Publishing House","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. J. Arch. Pathol."],"published-print":{"date-parts":[[2023,4,23]]},"abstract":"<jats:p>Objective. To study of nerve structures in the aortic wall in atherosclerosis using a complex of immunohistochemical markers. Material and methods. The objects of the study were excised fragments of the wall of the thoracic and abdominal aorta along with visually determined unstable atherosclerotic plaques. To study nerve structures on paraffin sections, immunohistochemical reactions were performed for the PGP 9.5 protein, tyrosine hydroxylase, and synaptophysin. Results. It has been established that pronounced pathological changes are observed in the nervous structures of the aortic wall near unstable atherosclerotic plaques. Reactive, dystrophic, and severe degenerative changes in neurocytes, nerve fibers, and glial cells are described in the elements of the nervous apparatus of the adventitia (microganglia, nerve trunks, and nerve plexuses). It was found that only sympathetic neurons and their postganglionic fibers remain in the intramural ganglia, while the structures of the parasympathetic nervous apparatus undergo degeneration. Destruction of perivascular nerve plexuses and vasa vasorum in the adventitia, as well as degeneration of varicose axons of the main terminal synaptic plexus at the border of adventitia and superficial smooth muscle layer of the media were demonstrated. Conclusion. It is assumed that the presence of inflammatory infiltrates in the adventitia and intima, denervation and death of vasa vasorum can serve as factors determining the development of the atherosclerotic process.<\/jats:p>","DOI":"10.17116\/patol20238503112","type":"journal-article","created":{"date-parts":[[2023,6,5]],"date-time":"2023-06-05T10:11:55Z","timestamp":1685959915000},"page":"12","source":"Crossref","is-referenced-by-count":2,"title":["Pathological changes in the nervous structures of the aortic wall tissue adjacent to an unstable atherosclerotic plaque"],"prefix":"10.17116","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4859-6766","authenticated-orcid":false,"given":"E.I.","family":"Chumasov","sequence":"first","affiliation":[{"name":"Institute of Experimental Medicine","place":["St. Petersburg, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2456-8165","authenticated-orcid":false,"given":"D.E.","family":"Korzhevskii","sequence":"additional","affiliation":[{"name":"Institute of Experimental Medicine","place":["St. Petersburg, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0972-8658","authenticated-orcid":false,"given":"E.S.","family":"Petrova","sequence":"additional","affiliation":[{"name":"Institute of Experimental Medicine","place":["St. Petersburg, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6248-9468","authenticated-orcid":false,"given":"O.G.","family":"Yakovleva","sequence":"additional","affiliation":[{"name":"Institute of Experimental Medicine","place":["St. Petersburg, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5906-6771","authenticated-orcid":false,"given":"P.V.","family":"Pigarevsky","sequence":"additional","affiliation":[{"name":"Institute of Experimental Medicine","place":["St. Petersburg, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/patol20238503112-1","unstructured":"Grigor\u2019eva TA. Innervatsiya krovenosnykh sosudov. M.: Medgiz; 1954. (In Russ.)"},{"key":"key-10.17116\/patol20238503112-2","unstructured":"Kupriyanov VV. Nervnyi apparat sosudov malogo kruga krovoobrashcheniya. L.: Medgiz. Leningradskoe otdelenie; 1959. (In Russ.)"},{"key":"key-10.17116\/patol20238503112-3","unstructured":"Semenov SP. Morfologiya vegetativnoi nervnoi sistemy i interoretseptorov. L.: Izdatel\u2019stvo LGU; 1965. (In Russ.)"},{"key":"key-10.17116\/patol20238503112-4","unstructured":"Govyrin VA, Leont\u2019eva GR. Mediatornye mekhanizmy regulyatsii krovenosnykh sosudov. In: Tkachenko B.I., ed. Fiziologiya krovoobrashcheniya. Regulyatsiya krovoobrashcheniya. L.: Nauka. Leningradskoe otdelenie; 1986;154-185. (In Russ.)"},{"key":"key-10.17116\/patol20238503112-5","unstructured":"Shvalev VN, Kargina-Terent\u2019eva RA, Kareeeva NI. Fenomen ochagovoi desimpatizatsii magistral\u2019nykh sosudov pri razvitii ateroskleroza. Morfologiya. 1996;110(4):92-100. 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Immunomorfologicheskoe issledovanie neirososudistykh vzaimootnoshenii v stenke aorty cheloveka v zone formirovaniya nestabil\u2019nykh ateroskleroticheskikh porazhenii. Tsitokiny i Vospalenie. 2018;17(1-4):49-55. 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