{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:23:35Z","timestamp":1747200215053,"version":"3.40.5"},"reference-count":11,"publisher":"Media Sphere Publishing House","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. J. Arch. Pathol."],"published-print":{"date-parts":[[2023,4,23]]},"abstract":"<jats:p>Sclerosing mucoepidermoid carcinoma with stromal eosinophilia of thyroid gland is represented less than 100 cases in the world literature. We present a rare case of sclerosing mucoepidermoid carcinona with stromal eosinophilia in a 69-year-old woman who has been observed for multinodular goiter for more than 3 years. Cytological examination revealed a picture most of all corresponding to a malignant neoplasm (Bethesda V). The patient underwent a thyroidectomy. Pathomorphological examination revealed a neoplasm of mixed structure with foci of cribriform structures and squamous metaplasia with areas of keratinization. According to the IHC study, the expression of TTF-1, p63, cytokeratins 5\/6 were positive, while there were no expression of thyroglobulin with its positive reaction in the thyroid tissue. Additional histochemical staining with Alcian blue revealed a positive reaction with a homogeneous acellular substance of the tumor. A comprehensive morphological study with the use of additional stains made it possible to accurately establish the diagnosis, which will determine the further tactics of managing the patient.<\/jats:p>","DOI":"10.17116\/patol20238506147","type":"journal-article","created":{"date-parts":[[2023,11,27]],"date-time":"2023-11-27T16:23:23Z","timestamp":1701102203000},"page":"47","source":"Crossref","is-referenced-by-count":0,"title":["Sclerosing mucoepidermoid carcinoma with eosinophilia of thyroid gland"],"prefix":"10.17116","volume":"85","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8284-9996","authenticated-orcid":false,"given":"A.Yu.","family":"Abrosimov","sequence":"first","affiliation":[{"name":"Endocrinology Research Center","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2122-2297","authenticated-orcid":false,"given":"E.V.","family":"Bondarenko","sequence":"additional","affiliation":[{"name":"Endocrinology Research Center","place":["Moscow, Russia"]},{"name":"Moscow Regional Research and Clinical Institute","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6822-0435","authenticated-orcid":false,"given":"D.A.","family":"Pastuhova","sequence":"additional","affiliation":[{"name":"Endocrinology Research Center","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8150-1461","authenticated-orcid":false,"given":"M.E.","family":"Beloshitsky","sequence":"additional","affiliation":[{"name":"Moscow Regional Research and Clinical Institute","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/patol20238506147-1","unstructured":"WHO Classification of Tumours Editorial Board. WHO classification of tumours series. Endocrine and neuroendocrine tumours. 5th ed. Vol. 8. France, Lyon: International Agency for Research on Cancer; 2022"},{"key":"key-10.17116\/patol20238506147-2","doi-asserted-by":"crossref","unstructured":"Chan JK, Albores-Saavedra J, Battifora H, Carcangiu ML, Rosai J. Sclerosing mucoepidermoid thyroid carcinoma with eosinophilia. A distinctive low-grade malignancy arising from the metaplastic follicles of Hashimoto\u2019s thyroiditis. Am J Surg Pathol. 1991;15(5): 438-448","DOI":"10.1097\/00000478-199105000-00003"},{"key":"key-10.17116\/patol20238506147-3","doi-asserted-by":"publisher","DOI":"10.1016\/j.humpath.2015.01.012"},{"key":"key-10.17116\/patol20238506147-4","unstructured":"Rusinovich AI, Leonova TA, Demidchik YuE. Skleroziruyushchii mukoepidermoidnyi rak shchitovidnoi zhelezy s eozinofiliei. Onkologicheskii Zhurnal. 2017;11(1):79-83. (In Russ.)"},{"key":"key-10.17116\/patol20238506147-5","doi-asserted-by":"publisher","DOI":"10.1002\/(SICI)1097-0339(199611)15:4<301::AID-DC10>3.0.CO;2-S"},{"key":"key-10.17116\/patol20238506147-6","doi-asserted-by":"publisher","DOI":"10.1093\/ajcp\/109.3.294"},{"key":"key-10.17116\/patol20238506147-7","doi-asserted-by":"publisher","DOI":"10.4103\/0970-9371.175511"},{"key":"key-10.17116\/patol20238506147-8","doi-asserted-by":"publisher","DOI":"10.1038\/modpathol.3800021"},{"key":"key-10.17116\/patol20238506147-9","unstructured":"Selivanova LS, Tertychnyi AS. Skleroziruyushchii mukoepidermoidnyi rak shchitovidnoi zhelezy s eozinofiliei. Arkhiv Patologii. 2013;75(5):44-49. (In Russ.)"},{"key":"key-10.17116\/patol20238506147-10","doi-asserted-by":"publisher","DOI":"10.1016\/j.ciresp.2014.06.005"},{"key":"key-10.17116\/patol20238506147-11","unstructured":"Lai CY, Chao TC, Lin JD, Hsueh C. Sclerosing mucoepidermoid carcinoma with eosinophilia of thyroid gland in a male patient: a case report and literature review. Int J Clin Exp Pathol. 2015;8(5):5947-5951"}],"container-title":["Russian Journal of Archive of Pathology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T14:38:48Z","timestamp":1745419128000},"score":1,"resource":{"primary":{"URL":"https:\/\/mediasphera.ru\/issues\/arkhiv-patologii\/2023\/6\/1000419552023061047"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,4,23]]},"references-count":11,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2023,11,27]]}},"alternative-id":["10.17116\/patol20238506147"],"URL":"https:\/\/doi.org\/10.17116\/patol20238506147","relation":{},"ISSN":["0004-1955"],"issn-type":[{"type":"print","value":"0004-1955"}],"subject":[],"published":{"date-parts":[[2023,4,23]]}}}