{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,5,14]],"date-time":"2025-05-14T05:23:35Z","timestamp":1747200215652,"version":"3.40.5"},"reference-count":13,"publisher":"Media Sphere Publishing House","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. J. Arch. Pathol."],"published-print":{"date-parts":[[2024,2,6]]},"abstract":"<jats:p>Background. Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) consist of lymphocyte predominant cell or LP-cell. Despite their origin from active germinal centers, in some cases LP-cells express IgD, which is characteristic of naive B-lymphocytes of the mantle zone. Due to the rarity of NLPHL, assessing the frequency of IgD-positive cases is difficult. This marker can serve not only for differential diagnosis with other diseases, but also indicate the possible heterogeneity of NLPHL, which is currently represented by six immunoarchitectural patterns. Objective. To determine the frequency of IgD-positive cases of NLPHL in children with subsequent assessment of the association with types of immunoarchitectural patterns. Material and methods. The study included 52 cases of NLPHL, which were divided to typical and atypical patterns. Differences between two groups were compared using Fisher\u2019s exact tests. Results. IgD expression was found in LP-cells in 26 of 52 cases (50%) and was positively correlated with atypical types (typical \u2014 5\/23, 21.7% vs atypical \u2014 21\/29, 72.4%, p=0.0003), among which pattern C was most common. Conclusion. Due to the high incidence of IgD-positive cases in NLPHL, this marker may be useful in differential diagnosis with histologic mimics. At the same time, positive IgD status was associated with atypical patterns, which may likely determine the different biology of neoplastic cells within the same form.<\/jats:p>","DOI":"10.17116\/patol20248601121","type":"journal-article","created":{"date-parts":[[2024,2,6]],"date-time":"2024-02-06T15:25:21Z","timestamp":1707233121000},"page":"21","source":"Crossref","is-referenced-by-count":0,"title":["IgD expression in various immunoarchitectural patterns of nodular lymphocyte predominant Hodgkin lymphoma in children"],"prefix":"10.17116","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9921-5620","authenticated-orcid":false,"given":"M.A.","family":"Senchenko","sequence":"first","affiliation":[{"name":"Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7732-8184","authenticated-orcid":false,"given":"D.M.","family":"Konovalov","sequence":"additional","affiliation":[{"name":"Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/patol20248601121-1","doi-asserted-by":"publisher","DOI":"10.1084\/jem.20080809"},{"key":"key-10.17116\/patol20248601121-2","doi-asserted-by":"publisher","DOI":"10.1182\/blood-2007-03-082511"},{"key":"key-10.17116\/patol20248601121-3","doi-asserted-by":"publisher","DOI":"10.1182\/blood.v87.2.465.bloodjournal872465"},{"key":"key-10.17116\/patol20248601121-4","doi-asserted-by":"publisher","DOI":"10.1200\/JCO.1999.17.3.776"},{"key":"key-10.17116\/patol20248601121-5","doi-asserted-by":"publisher","DOI":"10.1097\/00000478-200310000-00007"},{"key":"key-10.17116\/patol20248601121-6","unstructured":"Swerdlow SH, Campo E, Harris NL, Jaffe ES, Pileri SA, Stein H, Thiele J, eds. WHO classification of tumours of haematopoietic and lymphoid tissues. 4th ed. IARC: Lyon, France; 2017;588"},{"key":"key-10.17116\/patol20248601121-7","doi-asserted-by":"publisher","DOI":"10.1309\/YCH8-DWUF-FQBK-GPVB"},{"key":"key-10.17116\/patol20248601121-8","unstructured":"Herbeck R, Teodorescu Br\u00eenzeu D, Giubelan M, Laz\u01cer E, Dema A, Ioni\u0163\u01ce H. B-cell transcription factors Pax-5, Oct-2, BOB.1, Bcl-6, and MUM1 are useful markers for the diagnosis of nodular lymphocyte predominant Hodgkin lymphoma. Rom J Morphol Embryol. 2011;52(1):69-74"},{"key":"key-10.17116\/patol20248601121-9","doi-asserted-by":"publisher","DOI":"10.1097\/01.pas.0000194741.87798.45"},{"key":"key-10.17116\/patol20248601121-10","doi-asserted-by":"publisher","DOI":"10.1002\/pbc.26753"},{"key":"key-10.17116\/patol20248601121-11","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.13540"},{"key":"key-10.17116\/patol20248601121-12","doi-asserted-by":"publisher","DOI":"10.1111\/bjh.12997"},{"key":"key-10.17116\/patol20248601121-13","doi-asserted-by":"publisher","DOI":"10.1182\/blood.V95.4.1443.004k55_1443_1450"}],"container-title":["Russian Journal of Archive of Pathology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T04:43:19Z","timestamp":1745296999000},"score":1,"resource":{"primary":{"URL":"https:\/\/mediasphera.ru\/issues\/arkhiv-patologii\/2024\/1\/1000419552024011021"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,2,6]]},"references-count":13,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2024,2,6]]}},"alternative-id":["10.17116\/patol20248601121"],"URL":"https:\/\/doi.org\/10.17116\/patol20248601121","relation":{},"ISSN":["0004-1955"],"issn-type":[{"type":"print","value":"0004-1955"}],"subject":[],"published":{"date-parts":[[2024,2,6]]}}}