{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,4,23]],"date-time":"2025-04-23T04:08:57Z","timestamp":1745381337622,"version":"3.40.4"},"reference-count":7,"publisher":"Media Sphere Publishing House","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. J. Arch. Pathol."],"published-print":{"date-parts":[[2024,12,17]]},"abstract":"<jats:p>Surgical options for organ-preserving operations on the cervix (conization and contour-loop excision (C-LETZ)) regarding squamous intraepithelial lesions, morphological features of the cervix after surgery are determined, which are significant for HPV persistence and reproductive function. Objective. To evaluate the results of a lifetime pathoanatomic examination of the surgical material of cervical conization with diathermy loops of various shapes and sizes \u2014 a triangular loop and a wavy C-LETZ loop. Material and methods. The study included 49 patients with a clinical diagnosis of high-severity squamous intraepithelial lesion (HSIL), established by the results of a cytological smear examination or a previous histological examination of a cervical biopsy at the Moscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. Krasnopolsky from 2016 to 2023. Histological examination of resected cervical cones (n=32) and wavy C-LETZ cones (n=17) was performed. Results. At a cone height of less than 1.5 cm, both edges of the resection enter the section. With a higher cone height \u2014 1.5\u20142cm \u2014 the endocervical edge of the resection can be examined by cutting and labeling it in a separate cassette. Undulating C-LETZ conization ensures excision of the crypts of the endocervix to a depth of 0.5 cm not only throughout, but also in the endocervical edge of the excision. Conclusion. The analysis of the results of a lifetime pathoanatomic examination of the surgical material of conization with a triangular loop and a wavy C-LETZ loop showed the advantages and disadvantages of each of the studied variants of organ-preserving surgery. The advantage of wavy C-LETZ conization is the deep excision of the crypts of the endocervix throughout the cone, including the endocervical edge of conization.<\/jats:p>","DOI":"10.17116\/patol20248606143","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T09:25:30Z","timestamp":1734427530000},"page":"43","source":"Crossref","is-referenced-by-count":0,"title":["Clinical morphology of cervical conization variants for high-grade squamous intraepithelial lesions"],"prefix":"10.17116","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5958-5336","authenticated-orcid":false,"given":"I.V.","family":"Kardava","sequence":"first","affiliation":[{"name":"Moscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. Krasnopolsky","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0447-1734","authenticated-orcid":false,"given":"I.V.","family":"Barinova","sequence":"additional","affiliation":[{"name":"Moscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. Krasnopolsky","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5889-7696","authenticated-orcid":false,"given":"A.R.","family":"Fattakhov","sequence":"additional","affiliation":[{"name":"Moscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. Krasnopolsky","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3384-5096","authenticated-orcid":false,"given":"O.V.","family":"Trishhenkova","sequence":"additional","affiliation":[{"name":"Moscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. Krasnopolsky","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6155-788X","authenticated-orcid":false,"given":"N.V.","family":"Zarochentseva","sequence":"additional","affiliation":[{"name":"Moscow Regional Research Institute of Obstetrics and Gynecology named after Academician V.I. Krasnopolsky","place":["Moscow, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/patol20248606143-1","doi-asserted-by":"publisher","DOI":"10.24411\/2303-9698-2020-14005"},{"key":"key-10.17116\/patol20248606143-2","unstructured":"Zhirardi F, Ra\u012dkh O, Tamussino K, Pikel\u2019 Kh. Kol\u2019poskopiya i patologiya she\u01d0ki matki po Burgkhardu. Moscow: MEDpress-inform; 2018. 240p. (In Russ.)"},{"key":"key-10.17116\/patol20248606143-3","unstructured":"Firichenko SV, Manukhin IB, Minkina GN, Alieva MI. Ekstsizionnoe lechenie tservikal\u2019noi intraepitelial\u2019noi neoplazii i risk prezhdevremennykh rodov. Problemy Reproduktsii. 2012;(4):95-99. (In Russ.)"},{"key":"key-10.17116\/patol20248606143-4","doi-asserted-by":"publisher","DOI":"10.7314\/apjcp.2014.15.15.6005"},{"key":"key-10.17116\/patol20248606143-5","doi-asserted-by":"publisher","DOI":"10.1080\/00016340500345618"},{"key":"key-10.17116\/patol20248606143-6","unstructured":"Janthanaphan M, Wootipoom V, Tangsinmunkong K, Liabsuetrakul T. Comparison of success rate and complications of contour-loop excision of the transformation zone (C-LETZ) with cold knife conization (CKC) in high grade lesion (HGL) from colposcopic impression. J Med Assoc Thai. 2009;92(12):1573-1579"},{"key":"key-10.17116\/patol20248606143-7","doi-asserted-by":"publisher","DOI":"10.1097\/LGT.0000000000000329"}],"container-title":["Russian Journal of Archive of Pathology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T04:44:11Z","timestamp":1745297051000},"score":1,"resource":{"primary":{"URL":"https:\/\/mediasphera.ru\/issues\/arkhiv-patologii\/2024\/6\/1000419552024061043"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,17]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12,17]]}},"alternative-id":["10.17116\/patol20248606143"],"URL":"https:\/\/doi.org\/10.17116\/patol20248606143","relation":{},"ISSN":["0004-1955"],"issn-type":[{"type":"print","value":"0004-1955"}],"subject":[],"published":{"date-parts":[[2024,12,17]]}}}