{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T19:01:06Z","timestamp":1788894066087,"version":"build-2803163510"},"reference-count":7,"publisher":"Media Sphere Publishing House","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. J. Arch. Pathol."],"published-print":{"date-parts":[[2024,12,17]]},"abstract":"<jats:p>The molecular classification of endometrial cancer developed by The Cancer Genome Atlas project (TCGA, 2013) is currently actively used in gynecological oncology. According to it, endometrial carcinoma is divided into four molecular subtypes: POLE-mutated, MMR deficient (dMMR), TP53-aberrant and unspecified. Endometrial cancer samples belonging to the dMMR and POLE-mutant types are characterized by specific genetic profiles reflecting the hyper- and ultramutant phenotypes of the tumor. At the same time POLE-mutated endometrial carcinomas recur rarely and exhibit the excellent prognosis. Here we report the rare case of 65 y.o. female patient with endometrioid carcinoma sharing immunohistochemical and molecular features of TP53-aberrant, MMR deficient and POLE-mutated subtypes.<\/jats:p>","DOI":"10.17116\/patol20248606158","type":"journal-article","created":{"date-parts":[[2024,12,17]],"date-time":"2024-12-17T09:25:30Z","timestamp":1734427530000},"page":"58","source":"Crossref","is-referenced-by-count":1,"title":["Endometrial adenocarcinoma with mutations in POLE, TP53 genes and microsatellite instability"],"prefix":"10.17116","volume":"86","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-7315-0878","authenticated-orcid":false,"given":"A.A.","family":"Chernev","sequence":"first","affiliation":[{"name":"Medical Institute named after Berezin Sergey","place":["St. Petersburg, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1920-9798","authenticated-orcid":false,"given":"E.D.","family":"Kravtcova","sequence":"additional","affiliation":[{"name":"Medical Institute named after Berezin Sergey","place":["St. Petersburg, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1855-9692","authenticated-orcid":false,"given":"V.M.","family":"Nechushkina","sequence":"additional","affiliation":[{"name":"Eurasian Federation of Oncology","place":["Moscow, Russia"]},{"name":"Privolzhsky Research Medical University","place":["Nizhny Novgorod, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.H.","family":"Abasov","sequence":"additional","affiliation":[{"name":"Medical Institute named after Berezin Sergey","place":["St. Petersburg, Russia"]},{"name":"Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8950-5368","authenticated-orcid":false,"given":"M.L.","family":"Filipenko","sequence":"additional","affiliation":[{"name":"Institute of Chemical Biology and Fundamental Medicine","place":["Novosibirsk, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1308-8622","authenticated-orcid":false,"given":"A.E.","family":"Druy","sequence":"additional","affiliation":[{"name":"Medical Institute named after Berezin Sergey","place":["St. Petersburg, Russia"]},{"name":"Dmitry Rogachev National Medical Research Center of Pediatric Hematology, Oncology and Immunology","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7522-6552","authenticated-orcid":false,"given":"G.A.","family":"Raskin","sequence":"additional","affiliation":[{"name":"Medical Institute named after Berezin Sergey","place":["St. Petersburg, Russia"]},{"name":"St. Petersburg State University","place":["St. Petersburg, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6743","reference":[{"key":"key-10.17116\/patol20248606158-1","doi-asserted-by":"publisher","DOI":"10.1016\/0090-8258(83)90111-7"},{"key":"key-10.17116\/patol20248606158-2","doi-asserted-by":"publisher","DOI":"10.1038\/nature12113"},{"key":"key-10.17116\/patol20248606158-3","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0214318"},{"key":"key-10.17116\/patol20248606158-4","doi-asserted-by":"publisher","DOI":"10.1016\/j.jmoldx.2016.10.002"},{"key":"key-10.17116\/patol20248606158-5","doi-asserted-by":"publisher","DOI":"10.1002\/path.5373"},{"key":"key-10.17116\/patol20248606158-6","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/dju402"},{"key":"key-10.17116\/patol20248606158-7","doi-asserted-by":"publisher","DOI":"10.1136\/ijgc-2020-002230"}],"container-title":["Russian Journal of Archive of Pathology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,4,22]],"date-time":"2025-04-22T04:44:14Z","timestamp":1745297054000},"score":1,"resource":{"primary":{"URL":"https:\/\/mediasphera.ru\/issues\/arkhiv-patologii\/2024\/6\/1000419552024061058"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12,17]]},"references-count":7,"journal-issue":{"issue":"6","published-print":{"date-parts":[[2024,12,17]]}},"alternative-id":["10.17116\/patol20248606158"],"URL":"https:\/\/doi.org\/10.17116\/patol20248606158","relation":{},"ISSN":["0004-1955"],"issn-type":[{"value":"0004-1955","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12,17]]}}}