{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T20:11:57Z","timestamp":1772655117152,"version":"3.50.1"},"reference-count":25,"publisher":"Media Sphere Publishing House","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. J. Arch. Pathol."],"published-print":{"date-parts":[[2025,9,3]]},"abstract":"<jats:p>The question of the degree of influence of uterine artery embolization (UAE) on fertility is open. It is important to evaluate the pathomorphological structure and functional activity of the endometrium, the disruption of which can lead to infertility. Objective. To study morpho-functional changes in the endometrium of patients with uterine fibroids before and after UAE. Material and methods. 116 patients were divided into 2 groups depending on the type of the leading fibroid node: 1st \u2014 54 patients examined with uterine fibroid (UF) types 2, 2\u20145, 3, 2nd \u2014 62 patients observed with UM types 4, 5, 6. The comparison group \u2014 30 healthy women. Aspiration biopsy of the endometrium was performed in the middle stage of the secretory phase before and 6\u201412 months after UAE. The percentage and maturity of pinopodes, the expression level of estrogen (ER), progesterone (PR) receptors in the glands, endometrial stroma, inflammatory markers (CD56+, CD138+) were determined. Results. The negative impact of UF on the morpho-functional state of the endometrium was determined. Changes were more pronounced in patients of 1st group. Stroma indices before and after UAE corresponded to comparison group in most patients. After UAE, the number of mature pinopodes decreased in 1st group, but not in 2nd group. ER and PR expression levels in the glandular component decreased in all patients, being consistently higher in 1st group. An increase in proinflammatory markers was observed only in 1st group. Conclusion. UF and UAE can disturb morpho-functional state of the endometrium. The impact assessment should be made taking into account the topographic and anatomical location of the myomatous node.<\/jats:p>","DOI":"10.17116\/patol20258704113","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T15:08:56Z","timestamp":1756912136000},"page":"13","source":"Crossref","is-referenced-by-count":1,"title":["Morpho-functional features of the endometrium in uterine leiomyoma before and after embolization of the uterine arteries"],"prefix":"10.17116","volume":"87","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5845-7511","authenticated-orcid":false,"given":"M.A.","family":"Kudimova","sequence":"first","affiliation":[{"name":"N.I. 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