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TRPS1 demonstrates high sensitivity, including in diagnostically challenging cases such as triple-negative and poorly differentiated carcinomas, where traditional markers (GATA3, mammaglobin) may be absent or weakly expressed. The advantages of TRPS1 in the differential diagnosis of metastatic lesions and its possible role in prognostic panels are highlighted. Methodological limitations of the using marker, standardization needs and future perspectives for clinical implementation are also discussed in article.<\/jats:p>","DOI":"10.17116\/patol20268801180","type":"journal-article","created":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T15:48:12Z","timestamp":1769528892000},"page":"80","source":"Crossref","is-referenced-by-count":0,"title":["TRPS1 as a novel immunohistochemical marker in breast cancer diagnosis"],"prefix":"10.17116","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1195-4008","authenticated-orcid":false,"given":"S.V.","family":"Vtorushin","sequence":"first","affiliation":[{"name":"Cancer Research Institute \u2014 Tomsk National Research Medical Center","place":["Tomsk, Russia"]},{"name":"Siberian State Medical University","place":["Tomsk, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1909-1681","authenticated-orcid":false,"given":"N.V.","family":"Krakhmal","sequence":"additional","affiliation":[{"name":"Cancer Research Institute \u2014 Tomsk National Research Medical Center","place":["Tomsk, Russia"]},{"name":"Siberian State Medical University","place":["Tomsk, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3868-2310","authenticated-orcid":false,"given":"S.S.","family":"Naumov","sequence":"additional","affiliation":[{"name":"Siberian State Medical University","place":["Tomsk, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/patol20268801180-1","doi-asserted-by":"publisher","DOI":"10.1053\/j.semdp.2022.04.002"},{"key":"key-10.17116\/patol20268801180-2","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000186"},{"key":"key-10.17116\/patol20268801180-3","doi-asserted-by":"publisher","DOI":"10.1097\/PAI.0000000000000304"},{"key":"key-10.17116\/patol20268801180-4","doi-asserted-by":"publisher","DOI":"10.1186\/s13058-022-01569-1"},{"key":"key-10.17116\/patol20268801180-5","doi-asserted-by":"publisher","DOI":"10.18632\/oncotarget.2291"},{"key":"key-10.17116\/patol20268801180-6","doi-asserted-by":"publisher","DOI":"10.1101\/gad.331371.119"},{"key":"key-10.17116\/patol20268801180-7","doi-asserted-by":"publisher","DOI":"10.1038\/s41379-020-00692-8"},{"key":"key-10.17116\/patol20268801180-8","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-024-01542-w"},{"key":"key-10.17116\/patol20268801180-9","doi-asserted-by":"publisher","DOI":"10.1186\/s13000-025-01623-4"},{"key":"key-10.17116\/patol20268801180-10","doi-asserted-by":"publisher","DOI":"10.1038\/71717"},{"key":"key-10.17116\/patol20268801180-11","doi-asserted-by":"publisher","DOI":"10.1093\/jnci\/92.17.1414"},{"key":"key-10.17116\/patol20268801180-12","doi-asserted-by":"publisher","DOI":"10.1016\/j.gene.2024.148880"},{"key":"key-10.17116\/patol20268801180-13","doi-asserted-by":"publisher","DOI":"10.1016\/j.prp.2022.154022"},{"key":"key-10.17116\/patol20268801180-14","doi-asserted-by":"publisher","DOI":"10.1093\/hmg\/ddn125"},{"key":"key-10.17116\/patol20268801180-15","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2008.03.009"},{"key":"key-10.17116\/patol20268801180-16","doi-asserted-by":"publisher","DOI":"10.4161\/cc.25267"},{"key":"key-10.17116\/patol20268801180-17","doi-asserted-by":"publisher","DOI":"10.1681\/ASN.2008091020"},{"key":"key-10.17116\/patol20268801180-18","unstructured":"Gai Z, Gui T, Muragaki Y. 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