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Picro-Mallory were used, immunohistochemical (IHC) reactions with antibodies to S-protein of SARS-CoV-2 and receptors for angiotensin converting enzyme type 2 (ACE 2). Results. S-protein of SARS-CoV-2 expression is found in cholangiocytes, vascular endothelium and mononuclear cells of portal tract infiltrate, and single hepatocytes, ACE 2 \u2014 in cholangiocytes and hepatocytes. Liver changes are consistent with the morphology of hypoxic hepatitis in combination with COVID-associated microangio-, coagulo-, and cholangiopathy. In some patients, secondary sclerosing cholangitis and liver fibrosis are formed in the outcome of the disease. Conclusion. The study results do not allow us to exclude the role of SARS-CoV-2 in the pathogenesis of liver damage in COVID-19. Specific features of hypoxic hepatitis in COVID-19 are microangio-, coagulo- and cholangiopathy. 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