{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T18:06:45Z","timestamp":1785434805054,"version":"3.56.0"},"reference-count":26,"publisher":"Media Sphere Publishing House","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Rus. J. Arch. Pathol."],"published-print":{"date-parts":[[2026,7,30]]},"abstract":"<jats:p>Objective. To study the morphological patterns of immune-related cutaneous lesions (irCLs) that occur during antitumor immunotherapy in cancer patients. Material and methods. The study included 48 patients with the following nosology: malignant neoplasms of the skin and soft tissues \u2014 20 patients (41.7%), malignant neoplasms of the genitourinary system \u2014 13 (27%), malignant neoplasms of the lungs and bronchi \u2014 9 (18.8%), malignant neoplasms of the upper respiratory tract \u2014 5 (10.4%), malignant neoplasms of the gastrointestinal tract \u2014 1 (2.1%), with immune-mediated skin lesions during treatment with pembrolizumab \u2014 25 (52.1%), nivolumab \u2014 18 (37.5%), prolgolimab \u2014 4 (8.3%), avelumab \u2014 1 (2.1%). Results. Among the irCLs in the study cohort, lichenoid \u2014 14 (29.2%) cases and psoriasiform \u2014 11 cases (22.9%) were predominant, while other morphological variants were significantly less common. IrCL morphologically mimic classic dermatoses, but have distinctive features indicating their drug-induced, immune-related nature. Conclusion. The study demonstrated that irCLs are clinically significant complications of PD-1\/PD-L1 inhibitor therapy. Histological analysis confirmed their immunoinflammatory nature and revealed characteristic morphological changes, emphasizing the importance of routine skin biopsies for optimal patient management.<\/jats:p>","DOI":"10.17116\/patol20268804120","type":"journal-article","created":{"date-parts":[[2026,7,30]],"date-time":"2026-07-30T17:35:43Z","timestamp":1785432943000},"page":"20","source":"Crossref","is-referenced-by-count":0,"title":["Morphological features of immune-related cutaneous adverse events associated with anti-PD-1\/PD-L1 cancer immunotherapy"],"prefix":"10.17116","volume":"88","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9585-8373","authenticated-orcid":false,"given":"A.Yu.","family":"Syryseva","sequence":"first","affiliation":[{"name":"Lomonosov Moscow State University","place":["Moscow, Russia"]},{"name":"Oncological Center No. 1 of Moscow City Hospital named after S.S. 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