{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T22:57:51Z","timestamp":1790809071680,"version":"4.1.0"},"reference-count":11,"publisher":"Media Sphere Publishing House","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stomatology"],"published-print":{"date-parts":[[2023,5,5]]},"abstract":"<jats:p>Objective. Improving the effectiveness of the treatment of chronic generalized periodontitis by photodynamic therapy (PDT) due to clinical and functional validation of the effects of a photosensitizer. Material and methods. A clinical and functional study and treatment of moderate chronic generalized periodontitis was carried out in 60 people (24 males and 36 females) aged 35 to 50 years without somatic pathology with orthognathic bite. The patients were divided into 2 groups depending on the type of treatment: group 1 (main) included 30 patients (17 males and 13 females, mean age of patients was 42.5\u00b13.3 years) who received comprehensive treatment consisting of oral sanitation, removal of dental plaque and curettage of periodontal pockets followed by PDT with 1% Geleophor gel using an AFS Spektr LED emitter with a wavelength of 660 nm and a power of 2.5 W, the course consisted of 4 procedures with exposure time of 7 minutes each; group 2 (control) included 30 patients (11 males and 19 females, mean age of patients was 43.0\u00b12.1 years) undergoing standard treatment followed by protective capping with no active therapeutic agent. The state of microcirculation in tissues was studied by the laser Doppler flowmetry (LDF) using the LAKK-M device (Lazma, Russia). Results. According to LDF data in both groups, it was found that the improvement of microcirculation in periodontal tissues after complex treatment is accompanied by an increase in blood flow and its activity, at that the level of oxygenation and specific oxygen consumption increased more pronounced after PDT, the effect persisted after 6 and 12 months. Conclusion. The use of PDT with LED emitter has a normalizing effect on the state of microcirculation and oxygenation in periodontal tissues.<\/jats:p>","DOI":"10.17116\/stomat202310202111","type":"journal-article","created":{"date-parts":[[2023,5,5]],"date-time":"2023-05-05T11:58:37Z","timestamp":1683287917000},"page":"11","source":"Crossref","is-referenced-by-count":8,"title":["The use of photodynamic therapy in the complex treatment of chronic generalized moderate periodontitis"],"prefix":"10.17116","volume":"102","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9448-9614","authenticated-orcid":false,"given":"F.F.","family":"Losev","sequence":"first","affiliation":[{"name":"Central Research Institute of Dentistry and Maxillofacial Surgery","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2936-0707","authenticated-orcid":false,"given":"E.K.","family":"Krechina","sequence":"additional","affiliation":[{"name":"Central Research Institute of Dentistry and Maxillofacial Surgery","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6330-6942","authenticated-orcid":false,"given":"E.V.","family":"Ivanova","sequence":"additional","affiliation":[{"name":"Russian Medical Academy for Continuous Professional Education","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7628-8678","authenticated-orcid":false,"given":"E.Yu.","family":"Kuksa","sequence":"additional","affiliation":[{"name":"Central Research Institute of Dentistry and Maxillofacial Surgery","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6226-4819","authenticated-orcid":false,"given":"I.E.","family":"Guseva","sequence":"additional","affiliation":[{"name":"Central Research Institute of Dentistry and Maxillofacial Surgery","place":["Moscow, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6743","reference":[{"key":"key-10.17116\/stomat202310202111-1","unstructured":"Grudyanov AI, Fomenko EV. Methods of conservative treatment of inflammatory periodontal diseases. M.: MIA; 2013. (In Russ.)"},{"key":"key-10.17116\/stomat202310202111-2","unstructured":"Dmitrieva LA. Therapeutic dentistry. National guidelines. M.: GEOTAR-Media; 2015. (In Russ.)"},{"key":"key-10.17116\/stomat202310202111-3","doi-asserted-by":"crossref","unstructured":"Konopka K, Goslinski T. Photodynamic therapy in dentistry. J Dent Res. 2007;8(86):694-707","DOI":"10.1177\/154405910708600803"},{"key":"key-10.17116\/stomat202310202111-4","doi-asserted-by":"crossref","unstructured":"Garcez AS, Nunez SC, Hamblin MR, Ribeiro MS. The antibacterial effect of photodynamic therapy in patients with necrotic pulp and periapical lesions. J Endod. 2008;2(34):138-142","DOI":"10.1016\/j.joen.2007.10.020"},{"key":"key-10.17116\/stomat202310202111-5","doi-asserted-by":"crossref","unstructured":"Lulic M, Leiggener Gorog I, Salvi GE, Ramseier CA, Mattheos N, Lang NP. Annual results of multiple complex photodynamic therapy in the treatment of periodontal diseases: principles of inspection, randomized controlled clinical trial. J Clin Periodontol. 2009;8(36):661-666","DOI":"10.1111\/j.1600-051X.2009.01432.x"},{"key":"key-10.17116\/stomat202310202111-6","unstructured":"Orekhova LYu, Loboda ES. The role of photodynamic therapy in the complex treatment of inflammatory periodontal diseases. Periodontology. 2013;2: 46-52 (In Russ.)"},{"key":"key-10.17116\/stomat202310202111-7","unstructured":"Efremova NV, Krechina EK, Volkov AV. The effectiveness of PDT in the correction of inflammatory changes in periodontal tissues according to experimental studies. Endodontics Today. 2016;2:13-15. (In Russ.)"},{"key":"key-10.17116\/stomat202310202111-8","unstructured":"Popova AE, Krikheli NI, Pustovoit EV. Changes in dental status in patients with the inclusion of photodynamic therapy in the complex treatment plan for moderate chronic generalized periodontitis. Russian Dentistry. 2013;3(5): 16-23. (In Russ.)"},{"key":"key-10.17116\/stomat202310202111-9","unstructured":"Krechina EK, Efremova NV, Mustafina FK. Efficiency of photodynamic therapy in the complex treatment of inflammatory periodontal diseases. Clinical dentistry. 2016;2(78):34-37. (In Russ.)"},{"key":"key-10.17116\/stomat202310202111-10","unstructured":"Karakov KG, Mayboroda YuN, Markarova GV, Elbekyan KS, Zelenskiy VA. Clinical and biochemical evaluation of the effectiveness of photodynamic therapy and antioxidants in the treatment of periodontitis. Periodontology. 2013;3(68):30-34. (In Russ.)"},{"key":"key-10.17116\/stomat202310202111-11","unstructured":"Demina KYu, Grishilova EN, Brazhnikova AN, Garazha SN, Batchaeva DD, Gotlib AO, Garazha NN, Khachaturov SS. Influence of photodynamic therapy on hemodynamics in periodontal tissues in the treatment of chronic generalized periodontitis. Basic Research. 2014;10-6:1094-1097. (In Russ.)"}],"container-title":["Stomatology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2025,4,24]],"date-time":"2025-04-24T16:20:10Z","timestamp":1745511610000},"score":1,"resource":{"primary":{"URL":"https:\/\/mediasphera.ru\/issues\/stomatologiya\/2023\/2\/1003917352023021011"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,5,5]]},"references-count":11,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2023,5,5]]}},"alternative-id":["10.17116\/stomat202310202111"],"URL":"https:\/\/doi.org\/10.17116\/stomat202310202111","relation":{},"ISSN":["0039-1735"],"issn-type":[{"value":"0039-1735","type":"print"}],"subject":[],"published":{"date-parts":[[2023,5,5]]}}}