{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T16:37:38Z","timestamp":1792687058482,"version":"4.5.0"},"reference-count":22,"publisher":"Media Sphere Publishing House","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Stomatology"],"published-print":{"date-parts":[[2026,10,22]]},"abstract":"<jats:p>Objective. To analyze the effectiveness of complex therapy for peri-implantitis based on bioregenerative technologies over a 3-year observation period, with an assessment of the dynamics of bone tissue growth and probing depth. Material and methods: A retrospective multicenter study analyzed 86 clinical cases of peri-implantitis in 86 patients with Osstem (South Korea) TS-series SA-coated implants. All peri-implantitis cases were managed according to a uniform protocol: surgical access, mechanical and chemical removal of microbial biofilm, filling of the defect with a 1:1 mixture of allogeneic bone graft material and autologous platelet-leukocyte concentrate (APLC), application of a bioresorbable membrane, and infiltration of the APLC into the flap tissue. The assessment included peri-implant pocket depth (PID), bleeding index (PBI), implant stability quotient (ISQ), bone loss (CBCT), and recurrence rate at 6, 12, 24, and 36 months. Success was defined as a decrease in PID of at least 2 mm, the absence of progressive bone loss (less than 0.5 mm per year), an increase in ISQ of at least 3 points, and the absence of recurrent inflammation over three years. The removed dental implants and surrounding bone were subjected to histological processing and microscopic examination. Results: Successful treatment was recorded in 60 patients (69.8%). The average ISQ increase was +9.3 points (p&lt;0.001), bone tissue gain was +0.7\u00b10.5 mm (p&lt;0.001). Progression of bone loss was observed in only 15.1% of patients. Relapses (new inflammation with bone loss) occurred in 12 patients (14.0%). Systemic antibiotics were used in only 4.7% of cases. Implant loss was 4.7% (4\/86), all in the group of severe peri-implantitis with associated risk factors. Success correlated with hygiene (p&lt;0.001) and smoking cessation (p=0.012). The bone tissue around the removed implants contains a large number of osteoclasts and macrophages, which corresponds to a high level of inflammation. Conclusion: A comprehensive bioregenerative strategy using allogeneic osteoplastic material in the form of mineralized spongy powder and ATLC provides high clinical efficacy, bone tissue stabilization, and a significant reduction in recurrence rates compared to traditional methods. This protocol minimizes the use of systemic antibiotics and offers a promising alternative for the treatment of chronic peri-implantitis.<\/jats:p>","DOI":"10.17116\/stomat202610505140","type":"journal-article","created":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:39:02Z","timestamp":1792683542000},"page":"40","source":"Crossref","is-referenced-by-count":0,"title":["Retrospective analysis of the effectiveness of complex therapy for peri-implantitis: from antibacterial sanitation to bioregenerative strategies"],"prefix":"10.17116","volume":"105","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4924-5792","authenticated-orcid":false,"given":"S.V.","family":"Sirak","sequence":"first","affiliation":[{"name":"Stavropol State Medical University","place":["Stavropol, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7004-3581","authenticated-orcid":false,"given":"M.G.","family":"Perikova","sequence":"additional","affiliation":[{"name":"Stavropol State Medical University","place":["Stavropol, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0573-7242","authenticated-orcid":false,"given":"N.I.","family":"Bykova","sequence":"additional","affiliation":[{"name":"Kuban State Medical University","place":["Krasnodar, Russia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"6743","reference":[{"key":"key-10.17116\/stomat202610505140-1","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13167"},{"key":"key-10.17116\/stomat202610505140-2","doi-asserted-by":"publisher","DOI":"10.1111\/prd.12417"},{"key":"key-10.17116\/stomat202610505140-3","doi-asserted-by":"publisher","DOI":"10.17816\/1728-2802-2020-24-4-225-228"},{"key":"key-10.17116\/stomat202610505140-4","doi-asserted-by":"publisher","DOI":"10.1007\/s00784-024-05755-7"},{"key":"key-10.17116\/stomat202610505140-5","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13006"},{"key":"key-10.17116\/stomat202610505140-6","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13564"},{"key":"key-10.17116\/stomat202610505140-7","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13239"},{"key":"key-10.17116\/stomat202610505140-8","doi-asserted-by":"publisher","DOI":"10.1186\/s40729-021-00388-x"},{"key":"key-10.17116\/stomat202610505140-9","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2303360168"},{"key":"key-10.17116\/stomat202610505140-10","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.20-0458"},{"key":"key-10.17116\/stomat202610505140-11","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13204"},{"key":"key-10.17116\/stomat202610505140-12","doi-asserted-by":"publisher","DOI":"10.1111\/cid.13198"},{"key":"key-10.17116\/stomat202610505140-13","doi-asserted-by":"publisher","DOI":"10.1111\/clr.14102"},{"key":"key-10.17116\/stomat202610505140-14","doi-asserted-by":"publisher","DOI":"10.3390\/jcm9061988"},{"key":"key-10.17116\/stomat202610505140-15","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13206"},{"key":"key-10.17116\/stomat202610505140-16","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2025.12.006"},{"key":"key-10.17116\/stomat202610505140-17","doi-asserted-by":"publisher","DOI":"10.1111\/clr.13818"},{"key":"key-10.17116\/stomat202610505140-18","doi-asserted-by":"publisher","DOI":"10.1002\/JPER.21-0103"},{"key":"key-10.17116\/stomat202610505140-19","doi-asserted-by":"publisher","DOI":"10.5051\/jpis.2103020151"},{"key":"key-10.17116\/stomat202610505140-20","doi-asserted-by":"publisher","DOI":"10.1111\/jcpe.13251"},{"key":"key-10.17116\/stomat202610505140-21","doi-asserted-by":"publisher","DOI":"10.1016\/j.adaj.2025.08.015"},{"key":"key-10.17116\/stomat202610505140-22","doi-asserted-by":"publisher","DOI":"10.1590\/1807-3107bor-2019.vol33.0074"}],"container-title":["Stomatology"],"original-title":[],"language":"en","deposited":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T15:39:10Z","timestamp":1792683550000},"score":1,"resource":{"primary":{"URL":"https:\/\/mediasphera.ru\/issues\/stomatologiya\/2026\/5\/1003917352026051040"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,22]]},"references-count":22,"journal-issue":{"issue":"5","published-print":{"date-parts":[[2026,10,22]]}},"alternative-id":["10.17116\/stomat202610505140"],"URL":"https:\/\/doi.org\/10.17116\/stomat202610505140","relation":{},"ISSN":["0039-1735"],"issn-type":[{"value":"0039-1735","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10,22]]}}}