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Examined substance was isolated from the thick tissues and animals\u2019 blood by acetone, cleaned with a change of solvent and macrocolumn chromatography using 30 \u00b5m \u00abSilasorb S-18\u00bb sorbent and acetonitrile-water (8:2) polar eluent. The analyte was identified by chromatographic behavior in the thin sorbent layer, retention time and set of positive ions in its mass spectrum, as well as by UV-spectrum. The analyte was determined quantitatively in bioactive matrix using UV-spectrophotometry. The methods were validated by criteria of linearity, selectivity, accuracy, precision, detection limits and quantitative determination. The main content of lercanidipine (mg\/100 g) was determined in the stomach content (198.183\u00b129.541), the stomach (195.312\u00b121.579), the small intestine (47.096\u00b13.947), the spleen (38.952\u00b13.532) and the liver (26.211\u00b12.232).<\/jats:p>","DOI":"10.17116\/sudmed20236605147","type":"journal-article","created":{"date-parts":[[2023,10,5]],"date-time":"2023-10-05T15:20:21Z","timestamp":1696519221000},"page":"47","source":"Crossref","is-referenced-by-count":0,"title":["Lercanidipine distribution in warm-blooded animals"],"prefix":"10.17116","volume":"66","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5899-0420","authenticated-orcid":false,"given":"L.L.","family":"Kvachakhiya","sequence":"first","affiliation":[{"name":"Kursk State Medical University","place":["Kursk, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8872-0691","authenticated-orcid":false,"given":"V.K.","family":"Shormanov","sequence":"additional","affiliation":[{"name":"Kursk State Medical University","place":["Kursk, Russia"]}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"6743","reference":[{"key":"key-10.17116\/sudmed20236605147-1","unstructured":"Mashkovskiy MD. 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