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A number of patients have enhanced CS and clinical manifestations as neuropathic sensitive phenomena. The mixed model of the development of chronic pain in joint diseases and its presence along with nociceptive (inflammatory) and neuropathic pain components may explain the discrepancy between joint inflammatory and structural changes and pain intensity, the presence of distant pain and sensitive disorders in the areas outside the joint, and sometimes the efficiency of anti-inflammatory therapy. The presence of the neuropathic pain component serves as a rationale for combined therapy by adding centrally acting drugs, such as anticonvulsants.<\/jats:p>","DOI":"10.17116\/terarkh20168812159-164","type":"journal-article","created":{"date-parts":[[2017,1,23]],"date-time":"2017-01-23T14:59:26Z","timestamp":1485183566000},"page":"159-164","source":"Crossref","is-referenced-by-count":4,"title":["Central regulation of pain in patients with joint disease and approaches to therapy"],"prefix":"10.26442","volume":"88","author":[{"given":"E S","family":"Filatova","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sh F","family":"Erdes","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"E G","family":"Filatova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"18344","published-online":{"date-parts":[[2016,12,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1186\/ar3306"},{"key":"ref2","doi-asserted-by":"publisher","DOI":"10.1016\/j.semarthrit.2011.04.005"},{"key":"ref3","doi-asserted-by":"publisher","DOI":"10.1016\/j.eujps.2009.07.006"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1016\/j.ejpain.2005.06.009"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.1002\/acr.21723"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.14412\/1995-4484-2014-631-635"},{"key":"ref7","unstructured":"\u0412\u0430\u043b\u044c\u0434\u043c\u0430\u043d \u0410.\u0412., \u0418\u0433\u043d\u0430\u0442\u043e\u0432 \u042e.\u0414. \u0426\u0435\u043d\u0442\u0440\u0430\u043b\u044c\u043d\u044b\u0435 \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u044b \u0431\u043e\u043b\u0438. \u041d\u0430\u0443\u043a\u0430; 1976:191."},{"key":"ref8","doi-asserted-by":"publisher","DOI":"10.1016\/0304-3959(91)90015-p"},{"key":"ref9","unstructured":"\u041a\u0443\u043a\u0443\u0448\u043a\u0438\u043d \u041c.\u041b., \u0425\u0438\u0442\u0440\u043e\u0432 \u041d.\u041a. \u041e\u0431\u0449\u0430\u044f \u043f\u0430\u0442\u043e\u043b\u043e\u0433\u0438\u044f \u0431\u043e\u043b\u0438. \u041c.: \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0430; 2004:144."},{"key":"ref10","unstructured":"\u041d\u0435\u0432\u0440\u043e\u043f\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0431\u043e\u043b\u044c: \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u043d\u0430\u0431\u043b\u044e\u0434\u0435\u043d\u0438\u044f. \u041f\u043e\u0434 \u0440\u0435\u0434\u0430\u043a\u0446\u0438\u0435\u0439 \u042f\u0445\u043d\u043e \u041d.\u041d., \u0410\u043b\u0435\u043a\u0441\u0435\u0435\u0432\u0430 \u0412.\u0412., \u041f\u043e\u0434\u0447\u0443\u0444\u0430\u0440\u043e\u0432\u043e\u0439 \u0415.\u0412., \u041a\u0443\u043a\u0443\u0448\u043a\u0438\u043d\u0430 \u041c.\u041b. \u041c.: \u0418\u0437\u0434\u0430\u0442\u0435\u043b\u044c\u0441\u0442\u0432\u043e \u0420\u0410\u041c\u041d; 2009:6-31."},{"key":"ref11","unstructured":"\u0422\u0440\u0438\u0443\u043c\u0444\u043e\u0432 \u0410.\u0412. \u0422\u043e\u043f\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439 \u043d\u0435\u0440\u0432\u043d\u043e\u0439 \u0441\u0438\u0441\u0442\u0435\u043c\u044b. \u041c.: \u041c\u0415\u0414\u043f\u0440\u0435\u0441\u0441-\u0438\u043d\u0444\u043e\u0440\u043c; 2007:258."},{"key":"ref12","unstructured":"Beneditti C. 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