{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,19]],"date-time":"2026-10-19T03:22:42Z","timestamp":1792380162334,"version":"4.4.0"},"reference-count":32,"publisher":"Consilium Medicum","issue":"9","license":[{"start":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T00:00:00Z","timestamp":1473897600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Aim. To define the role of circulating biomarkers for the metabolism of collagen and intercellular substance and vascular remodeling in the development of osteoporosis (OP) in idiopathic pulmonary arterial hypertension (IPAH). Materials and methods. Functional hemodynamic parameters, bone mineral density (BMD) in the lumbar spine and femoral neck and the serum levels of matrix metalloproteinase-9 (MMP-9), tissue inhibitor of metalloproteinase-1 (TIMP-1), MMP-9\/TIMP-1 complex, C-terminal telopeptide of collagen type 1 (CITP), and endothelin-1 (ET-1) were determined in 27 high-risk IPAH patients and 30 healthy volunteers. Results. OP in IPAH was detected in 50% of the examinees. The serum levels of CITP, MMP-9, TIMP-1, and ET-1 proved to be higher in the high-risk IPAH patients than in the healthy volunteers. There was a direct correlation between BMD and six-minute walk test and an inverse correlation with total pulmonary vascular resistance (TPVR). Serum TMIP-1 levels correlated with cardiac index and TPVR; ET-1 concentrations were directly related to pulmonary artery systolic pressure, cardiac index, and TPVR. Inverse relationships were found between BMD and circulating CITP, MMP-9, TMIP-1, MMP-9\/TMIP-1, and ET-1. At the same time, there was only a tendency towards a positive correlation between serum CITP and ET-1 concentrations. Conclusion. The results of the investigation confirm that endothelin system dysregulation plays a leading role in the development of persistent hemodynamic disorders in high-risk IPAH and suggest that it is involved in the development of osteopenic syndrome. Enhanced ET-1 secretion initiates bone loss possibly via activation of connective tissue matrix destruction.<\/jats:p>","DOI":"10.17116\/terarkh201688965-70","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T15:44:23Z","timestamp":1476200663000},"page":"65-70","source":"Crossref","is-referenced-by-count":1,"title":["Role of vascular remodeling markers in the development of osteoporosis in idiopathic pulmonary arterial hypertension"],"prefix":"10.26442","volume":"88","author":[{"given":"V A","family":"Nevzorova","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E A","family":"Kochetkova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L G","family":"Ugay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu V","family":"Maistrovskaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E A","family":"Khludeeva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18344","published-online":{"date-parts":[[2016,9,15]]},"reference":[{"key":"ref1","doi-asserted-by":"publisher","DOI":"10.1016\/j.transproceed.2012.09.117"},{"key":"ref2","unstructured":"Global Initiative for Chronic Obstructive Lung Disease (updated 2016).http:\/\/www.goldcopd.org\/uploads\/users\/files\/WatermarkedGlobal_20Strategy_202016(1).pdf"},{"key":"ref3","unstructured":"GINA Report, Global Strategy for Asthma Management and Prevention. http:\/\/ginasthma.org\/gina-report-global-strategy-for-asthma-management-and-prevention\/"},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.3109\/15412555.2010.482114"},{"key":"ref5","doi-asserted-by":"crossref","unstructured":"Vrieze A, de Greef MH, Wijkstra PJ, Wempe JB. Low bone mineral density in COPD patients related to worse lung function, low weight and decreased fat-free mass. Osteoporos Int. 2007;18(9):1197-1202.","DOI":"10.1007\/s00198-007-0355-7"},{"key":"ref6","doi-asserted-by":"publisher","DOI":"10.1007\/s00198-009-0890-5"},{"key":"ref7","doi-asserted-by":"crossref","unstructured":"Katsura H, Kida K. A comparison of bone mineral density in elderly female patients with COPD and bronchial asthma. Chest. 2002;122:1949-1955.","DOI":"10.1378\/chest.122.6.1949"},{"key":"ref8","unstructured":"\u041c\u0430\u0440\u0442\u044b\u043d\u044e\u043a \u0422.\u0412., \u0427\u0430\u0437\u043e\u0432\u0430 \u0418.\u0415. \u041d\u043e\u0432\u044b\u0435 \u0432\u043e\u0437\u043c\u043e\u0436\u043d\u043e\u0441\u0442\u0438 \u0432 \u0441\u0442\u0440\u0430\u0442\u0435\u0433\u0438\u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u044f \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0441 \u0438\u0434\u0438\u043e\u043f\u0430\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043b\u0435\u0433\u043e\u0447\u043d\u043e\u0439 \u0433\u0438\u043f\u0435\u0440\u0442\u0435\u043d\u0437\u0438\u0435\u0439: \u0430\u043d\u0442\u0430\u0433\u043e\u043d\u0438\u0441\u0442 \u0440\u0435\u0446\u0435\u043f\u0442\u043e\u0440\u043e\u0432 \u044d\u043d\u0434\u043e\u0442\u0435\u043b\u0438\u043d\u0430 \u0431\u043e\u0437\u0435\u043d\u0442\u0430\u043d. \u0421\u0438\u0441\u0442\u0435\u043c\u043d\u044b\u0435 \u0433\u0438\u043f\u0435\u0440\u0442\u0435\u043d\u0437\u0438\u0438. 2008;4:25-36. http:\/\/www.gipertonik.ru\/files\/journals\/SG4(2008).pdf"},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1093\/eurheartj\/ehv317"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Tschopp O, Schmid C, Speich R, Seifert B, Russi EW, Boehler A. Pretransplantation bone disease in patients with primary pulmonary hypertension. Chest. 2006;129:1002-1008.","DOI":"10.1378\/chest.129.4.1002"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1097\/SMJ.0b013e31825b8117"},{"key":"ref12","doi-asserted-by":"publisher","DOI":"10.3899\/jrheum.081088"},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.4172\/2324-8602.1000198"},{"key":"ref14","doi-asserted-by":"crossref","unstructured":"Alangiakrishman K, Juby A, Hanley D, Tymchak W, Sclater A. Role of vascular factors in osteoporosis. J Gerontol: Med Scie. 2003;58(4):362-366.","DOI":"10.1093\/gerona\/58.4.M362"},{"key":"ref15","doi-asserted-by":"publisher","DOI":"10.1253\/circj.71.1555"},{"key":"ref16","doi-asserted-by":"publisher","DOI":"10.2147\/VHRM.S63580"},{"key":"ref17","unstructured":"Delgado-Fr\u00edas E, L\u00f3pez-Mejias R, Genre F, Ubilla B, G\u00f3mez Rodr\u00edguez-Bethencourt MA, Gonz\u00e1lez-D\u00edaz A, de Vera-Gonz\u00e1lez AM, Gonz\u00e1lez-Rivero AF, D\u00edaz-Gonz\u00e1lez F, Gonz\u00e1lez-Gay MA, Ferraz-Amaro I. Relationship between endothelial dysfunction and osteoprotegerin, vitamin D, and bone mineral density in patients with rheumatoid arthritis. Clin Exp Rheumatol. 2015;33(2):241-249."},{"key":"ref18","doi-asserted-by":"publisher","DOI":"10.1016\/j.mad.2016.03.005"},{"key":"ref19","doi-asserted-by":"publisher","DOI":"10.1002\/cbf.2911"},{"key":"ref20","doi-asserted-by":"publisher","DOI":"10.4238\/2015.March.6.17"},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1186\/s12931-016-0343-6"},{"key":"ref22","doi-asserted-by":"publisher","DOI":"10.3109\/1354750X.2010.492431"},{"key":"ref23","unstructured":"Jiang L, Zhou T, Liu H. Combined effects of the ATP-sensitive potassium channel opener pinacidil and simvastatin on pulmonary vascular remodeling in rats with monocrotaline-induced pulmonary arterial hypertension. Pharmazie. 2012;67(6):547-552."},{"key":"ref24","unstructured":"\u041d\u0435\u0432\u0437\u043e\u0440\u043e\u0432\u0430 \u0412.\u0410., \u0422\u0438\u043b\u0438\u043a \u0422.\u0412., \u0413\u0438\u043b\u0438\u0444\u0430\u043d\u043e\u0432 \u0415.\u0410., \u041f\u0430\u043d\u0447\u0435\u043d\u043a\u043e \u0415.\u0410., \u0412\u0430\u0445\u0440\u0443\u0448\u0435\u0432\u0430 \u0421.\u0415., \u0422\u0438\u043b\u0438\u043a \u0412.\u0412. \u0420\u043e\u043b\u044c \u043c\u0430\u0442\u0440\u0438\u043a\u0441\u043d\u044b\u0445 \u043c\u0435\u0442\u0430\u043b\u043b\u043e\u043f\u0440\u043e\u0442\u0435\u0438\u043d\u0430\u0437 \u0432 \u0444\u043e\u0440\u043c\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u0438 \u043c\u043e\u0440\u0444\u043e\u0444\u0443\u043d\u043a\u0446\u0438\u043e\u043d\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0434\u0438\u0441\u0431\u0430\u043b\u0430\u043d\u0441\u0430 \u0432\u043e\u0437\u0434\u0443\u0445\u043e\u043d\u043e\u0441\u043d\u044b\u0445 \u043f\u0443\u0442\u0435\u0439 \u043f\u0440\u0438 \u0445\u0440\u043e\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043e\u0431\u0441\u0442\u0440\u0443\u043a\u0442\u0438\u0432\u043d\u043e\u0439 \u0431\u043e\u043b\u0435\u0437\u043d\u0438 \u043b\u0435\u0433\u043a\u0438\u0445. \u0422\u0438\u0445\u043e\u043e\u043a\u0435\u0430\u043d\u0441\u043a\u0438\u0439 \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b. 2011;2:9-13. \u0414\u043e\u0441\u0442\u0443\u043f\u043d\u043e \u043f\u043e: http:\/\/www.tmj-vgmu.ru\/files\/old\/PMJ_2009-2011\/1509.pdf"},{"key":"ref25","doi-asserted-by":"crossref","unstructured":"Bergers G, Brekken R, McMahon G, Vu TH, Itoh T, Tamaki K, Tanzawa K, Thorpe P, Itohara S, Werb Z, Hanahan D. Matrix metalloproteinase-9 triggers the angiogenic switch during carcinogenesis. Nat Cell Biol. 2000;2(10):737-744.","DOI":"10.1038\/35036374"},{"key":"ref26","doi-asserted-by":"crossref","unstructured":"Anderson TL, del Carem Ovejero M, Kirkegaard T et al. A scrutiny of matrix metalloproteinases in osteoclasts: evidence for heterogeneity and for the presence of MMPs synthesized by other cells. Bone. 2004;35:1107-1119.","DOI":"10.1016\/j.bone.2004.06.019"},{"key":"ref27","doi-asserted-by":"crossref","unstructured":"Li Y, Zhang Zh, Xu Yo et al. TNF-\u03b1 Up-regulates Matrix Metalloproteinase-9 Expression and Activity in Alveolar Macrophages from Patients with Chronic Obstructive Pulmonary Disease. J Huazhong University of Science and Technology 2006;26(6):647-650. doi:10.1007\/s 11596-006-0604-6","DOI":"10.1007\/s11596-006-0604-6"},{"key":"ref28","doi-asserted-by":"publisher","DOI":"10.1371\/journal.pone.0149269"},{"key":"ref29","doi-asserted-by":"publisher","DOI":"10.1016\/j.jchf.2014.03.013"},{"key":"ref30","doi-asserted-by":"publisher","DOI":"10.1164\/rccm.201501-0196OC"},{"key":"ref31","doi-asserted-by":"publisher","DOI":"10.1530\/JOE-15-0332"},{"key":"ref32","doi-asserted-by":"publisher","DOI":"10.1016\/j.bone.2010.05.041"}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/32076\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/32076\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T02:28:27Z","timestamp":1634092107000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/32076"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,15]]},"references-count":32,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2016,9,15]]}},"URL":"https:\/\/doi.org\/10.17116\/terarkh201688965-70","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"value":"2309-5342","type":"electronic"},{"value":"0040-3660","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9,15]]}}}