{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T21:09:03Z","timestamp":1791580143294,"version":"4.3.4"},"reference-count":27,"publisher":"Consilium Medicum","issue":"9","license":[{"start":{"date-parts":[[2016,9,15]],"date-time":"2016-09-15T00:00:00Z","timestamp":1473897600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-sa\/4.0"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Terapevticheskii arkhiv"],"abstract":"<jats:p>Aim. To determine the incidence of biliary sludge (BS) and to evaluate the clinical efficacy of Chophytol in patients with nonalcoholic steatohepatitis (NASH) and BS in the presence of metabolic syndrome (MS). Subjects and methods. Clinical laboratory examination was made in 72 patients with NASH in the presence of MS. BS was identified in 52 (72.2%) examinees who were divided in two (study and control) groups. The efficacy of Chophytol of plant origin, prepared from the purified extract of fresh artichoke (Cynara scolymus) leaf juice, which was used at a dose of 3 tablets thrice daily for a month, was evaluated. Results. The use of Chophytol was established to promote BS elimination in 87% of the patients. This ceased pain syndrome in 87% and dyspeptic manifestations in 65.2% and normalized the levels of lipids and the biochemical indicators of liver process activity. No adverse drug reactions were seen. Conclusion. Chophytol used in patients with HASH and BS may soon be possible to make general condition better, to alleviate the symptoms of diseases of the liver and biliary system, and to appreciably improve the biochemical indicators of blood and bile.<\/jats:p>","DOI":"10.17116\/terarkh201688978-83","type":"journal-article","created":{"date-parts":[[2016,10,11]],"date-time":"2016-10-11T15:44:23Z","timestamp":1476200663000},"page":"78-83","source":"Crossref","is-referenced-by-count":7,"title":["Nonalcoholic steatohepatitis and biliary sludge in people with metabolic syndrome"],"prefix":"10.26442","volume":"88","author":[{"given":"V G","family":"Radchenko","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P V","family":"Seliverstov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S S","family":"Ledentsova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A V","family":"Manyakov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"18344","published-online":{"date-parts":[[2016,9,15]]},"reference":[{"key":"ref1","unstructured":"\u041b\u0430\u0437\u0435\u0431\u043d\u0438\u043a \u041b.\u0411., \u0417\u0432\u0435\u043d\u0438\u0433\u043e\u0440\u043e\u0434\u0441\u043a\u0430\u044f \u041b.\u0410. \u041c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0441\u0438\u043d\u0434\u0440\u043e\u043c \u0441 \u043f\u043e\u0437\u0438\u0446\u0438\u0438 \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0430. \u0420\u041c\u0416. 2005;13,26:1706-1712."},{"key":"ref2","unstructured":"\u041b\u0430\u0437\u0435\u0431\u043d\u0438\u043a \u041b.\u0411., \u0417\u0432\u0435\u043d\u0438\u0433\u043e\u0440\u043e\u0434\u0441\u043a\u0430\u044f \u041b.\u0410. \u041c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0441\u0438\u043d\u0434\u0440\u043e\u043c \u0438 \u043e\u0440\u0433\u0430\u043d\u044b \u043f\u0438\u0449\u0435\u0432\u0430\u0440\u0435\u043d\u0438\u044f. \u041c.: \u0410\u043d\u0430\u0445\u0430\u0440\u0441\u0438\u0441; 2009."},{"key":"ref3","unstructured":"\u041c\u0430\u0435\u0432 \u0418.\u0412. \u0414\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439 \u0436\u0435\u043b\u0447\u0435\u0432\u044b\u0432\u043e\u0434\u044f\u0449\u0438\u0445 \u043f\u0443\u0442\u0435\u0439. \u041c.: \u0413\u041e\u0423 \u0412\u0423\u041d\u041c\u0426 \u041c\u0417 \u0420\u0424;2003."},{"key":"ref4","doi-asserted-by":"publisher","DOI":"10.1046\/j.1365-2362.2001.00834.x"},{"key":"ref5","doi-asserted-by":"publisher","DOI":"10.7326\/0003-4819-130-4-199902160-00016"},{"key":"ref6","unstructured":"\u0418\u043b\u044c\u0447\u0435\u043d\u043a\u043e \u0410.\u0410., \u0414\u0435\u043b\u044e\u043a\u0438\u043d\u0430 \u041e.\u0412. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0437\u043d\u0430\u0447\u0435\u043d\u0438\u0435 \u0431\u0438\u043b\u0438\u0430\u0440\u043d\u043e\u0433\u043e \u0441\u043b\u0430\u0434\u0436\u0430. Consilium Medicum. \u0413\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f. 2005;7(2):134-137."},{"key":"ref7","unstructured":"\u041c\u0435\u0445\u0442\u0438\u0435\u0432 \u0421.\u041d. \u0411\u0438\u043b\u0438\u0430\u0440\u043d\u044b\u0439 \u0441\u043b\u0430\u0434\u0436: \u043d\u0435\u0440\u0435\u0448\u0435\u043d\u043d\u044b\u0435 \u0432\u043e\u043f\u0440\u043e\u0441\u044b. \u041b\u0435\u0447\u0430\u0449\u0438\u0439 \u0432\u0440\u0430\u0447. 2007;6:24-28."},{"key":"ref8","unstructured":"\u0422\u043e\u043f\u0447\u0438\u0439 \u041d.\u0412., \u0422\u043e\u043f\u043e\u0440\u043a\u043e\u0432 \u0410.\u0421. \u0425\u043e\u043b\u0435\u043b\u0438\u0442\u0438\u0430\u0437 \u0438 \u0431\u0438\u043b\u0438\u0430\u0440\u043d\u044b\u0439 \u0441\u043b\u0430\u0434\u0436: \u0441\u043e\u0432\u0440\u0435\u043c\u0435\u043d\u043d\u044b\u0439 \u0432\u0437\u0433\u043b\u044f\u0434 \u043d\u0430 \u043f\u0440\u043e\u0431\u043b\u0435\u043c\u0443. \u041c.; 2011."},{"key":"ref9","doi-asserted-by":"publisher","DOI":"10.1016\/S1542-3565(05)00369-1"},{"key":"ref10","doi-asserted-by":"crossref","unstructured":"Fracchia M, Pellegrino S, Secreto P. Biliary lipid composition in cholesterol microloithiasis. Gut. 2001;48:702-706.","DOI":"10.1136\/gut.48.5.702"},{"key":"ref11","doi-asserted-by":"publisher","DOI":"10.1016\/j.bpg.2006.03.007"},{"key":"ref12","unstructured":"\u0422\u0443\u0445\u0442\u0430\u0435\u0432\u0430 \u041d.\u0421., \u041c\u0430\u043d\u0441\u0443\u0440\u043e\u0432 \u0425.\u0425., \u041c\u0430\u043d\u0441\u0443\u0440\u043e\u0432\u0430 \u0424.\u0425. \u041e \u043c\u043e\u043b\u0435\u043a\u0443\u043b\u044f\u0440\u043d\u043e\u043c \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u0435 \u0444\u043e\u0440\u043c\u0438\u0440\u043e\u0432\u0430\u043d\u0438\u044f \u0431\u0438\u043b\u0438\u0430\u0440\u043d\u043e\u0433\u043e \u0441\u043b\u0430\u0434\u0436\u0430. \u041f\u0440\u043e\u0431\u043b\u0435\u043c\u044b \u0413\u0410\u042d\u041b. 2006;1-2:40-47."},{"key":"ref13","doi-asserted-by":"publisher","DOI":"10.1002\/hep.20534"},{"key":"ref14","unstructured":"Caruso MG, Giangrande M, Clemente C. Serum lipids and biliary sludge during pregnancy. Minerva Gastroenterol Dietol. 1993;39(2):67-70."},{"key":"ref15","unstructured":"\u041c\u0438\u0442\u044c\u043a\u043e\u0432 \u0412.\u0412. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0440\u0443\u043a\u043e\u0432\u043e\u0434\u0441\u0442\u0432\u043e \u043f\u043e \u0443\u043b\u044c\u0442\u0440\u0430\u0437\u0432\u0443\u043a\u043e\u0432\u043e\u0439 \u0434\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0435: \u0432 4 \u0442. \u041c.: \u0412\u0438\u0434\u0430\u0440; 1996."},{"key":"ref16","unstructured":"\u0418\u043b\u044c\u0447\u0435\u043d\u043a\u043e \u0418.\u0418., \u0414\u0435\u043b\u044e\u043a\u0438\u043d\u0430 \u041e.\u0412. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0438\u0435 \u0430\u0441\u043f\u0435\u043a\u0442\u044b \u0431\u0438\u043b\u0438\u0430\u0440\u043d\u043e\u0433\u043e \u0441\u043b\u0430\u0434\u0436\u0430. Consilium medicum. 2007;9(7):23-32."},{"key":"ref17","doi-asserted-by":"crossref","unstructured":"Jungst C, Kullak-Ublick GA, Jungst D. Gallstone disease: microlithiasis and sludge. Best Pract Res Gastroenterol. 2006;20(6):1053-1062.","DOI":"10.1016\/j.bpg.2006.03.007"},{"key":"ref18","unstructured":"\u0418\u043b\u044c\u0447\u0435\u043d\u043a\u043e \u0410.\u0410., \u0412\u0438\u0445\u0440\u043e\u0432\u0430 \u0422.\u0412., \u0421\u0438\u043b\u044c\u0432\u0435\u0441\u0442\u0440\u043e\u0432\u0430 \u0421.\u042e. \u0411\u0438\u043e\u0445\u0438\u043c\u0438\u0447\u0435\u0441\u043a\u043e\u0435 \u0438\u0441\u0441\u043b\u0435\u0434\u043e\u0432\u0430\u043d\u0438\u0435 \u0436\u0435\u043b\u0447\u0438 \u0443 \u0431\u043e\u043b\u044c\u043d\u044b\u0445 \u0441 \u0431\u0438\u043b\u0438\u0430\u0440\u043d\u044b\u043c \u0441\u043b\u0430\u0434\u0436\u0435\u043c \u0432 \u043a\u0430\u0447\u0435\u0441\u0442\u0432\u0435 \u043f\u0440\u043e\u0433\u043d\u043e\u0441\u0442\u0438\u0447\u0435\u0441\u043a\u043e\u0433\u043e \u043a\u0440\u0438\u0442\u0435\u0440\u0438\u044f \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044f \u0445\u043e\u043b\u0435\u0446\u0438\u0441\u0442\u043e\u043b\u0438\u0442\u0438\u0430\u0437\u0430. \u0420\u043e\u0441\u0441\u0438\u0439\u0441\u043a\u0438\u0439 \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0436\u0443\u0440\u043d\u0430\u043b. 2000;4:46-53."},{"key":"ref19","unstructured":"\u0418\u043b\u044c\u0447\u0435\u043d\u043a\u043e \u0410.\u0410., \u0412\u0438\u0445\u0440\u043e\u0432\u0430 \u0422.\u0412., \u041e\u0440\u043b\u043e\u0432\u0430 \u042e.\u041d. \u0411\u0438\u043b\u0438\u0430\u0440\u043d\u044b\u0439 \u0441\u043b\u0430\u0434\u0436: \u043e\u0442 \u043f\u0430\u0442\u043e\u0433\u0435\u043d\u0435\u0437\u0430 \u043a \u043b\u0435\u0447\u0435\u043d\u0438\u044e. \u041c\u0435\u0442\u043e\u0434. \u0440\u0435\u043a\u043e\u043c\u0435\u043d\u0434\u0430\u0446\u0438\u0438. \u041c.: \u0426\u041d\u0418\u0418\u0413\u042d; 2006."},{"key":"ref20","unstructured":"\u0418\u043b\u044c\u0447\u0435\u043d\u043a\u043e \u0410.\u0410. \u0417\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u044f \u0436\u0435\u043b\u0447\u043d\u043e\u0433\u043e \u043f\u0443\u0437\u044b\u0440\u044f \u0438 \u0436\u0435\u043b\u0447\u043d\u044b\u0445 \u043f\u0443\u0442\u0435\u0439. \u041c.: \u0410\u043d\u0430\u0445\u0430\u0440\u0441\u0438\u0441; 2006."},{"key":"ref21","doi-asserted-by":"publisher","DOI":"10.1111\/j.1872-034X.2007.00297.x"},{"key":"ref22","unstructured":"\u0420\u0430\u0434\u0447\u0435\u043d\u043a\u043e \u0412.\u0413., \u0421\u0430\u0444\u0440\u043e\u043d\u0435\u043d\u043a\u043e\u0432\u0430 \u0418.\u0413., \u0421\u0438\u0442\u043a\u0438\u043d \u0421.\u0418. \u041c\u0435\u0434\u0438\u043a\u0430\u043c\u0435\u043d\u0442\u043e\u0437\u043d\u044b\u0439 \u043b\u0438\u0442\u043e\u043b\u0438\u0437 \u043f\u0440\u0435\u043f\u0430\u0440\u0430\u0442\u043e\u043c \u0423\u0440\u0441\u043e\u0444\u0430\u043b\u044c\u043a. \u0423\u0441\u043e\u0432\u0435\u0440\u0448\u0435\u043d\u0441\u0442\u0432\u043e\u0432\u0430\u043d\u043d\u0430\u044f \u043c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0430\u044f \u0442\u0435\u0445\u043d\u043e\u043b\u043e\u0433\u0438\u044f. \u0421\u041f\u0431.: \u0424\u0435\u0434\u0435\u0440\u0430\u043b\u044c\u043d\u043e\u0435 \u0430\u0433\u0435\u043d\u0442\u0441\u0442\u0432\u043e \u043f\u043e \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044e \u0438 \u0441\u043e\u0446. \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044e, \u0413\u043e\u0441. \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u0442\u0435\u043b\u044c\u043d\u043e\u0435 \u0443\u0447\u0440\u0435\u0436\u0434\u0435\u043d\u0438\u0435 \u0432\u044b\u0441\u0448. \u043f\u0440\u043e\u0444. \u043e\u0431\u0440\u0430\u0437\u043e\u0432\u0430\u043d\u0438\u044f \u0421\u0430\u043d\u043a\u0442-\u041f\u0435\u0442\u0435\u0440\u0431\u0443\u0440\u0433\u0441\u043a\u0430\u044f \u0433\u043e\u0441. \u043c\u0435\u0434. \u0430\u043a\u0430\u0434. \u0438\u043c. \u0418.\u041c. \u041c\u0435\u0447\u043d\u0438\u043a\u043e\u0432\u0430 \u0424\u0435\u0434\u0435\u0440\u0430\u043b\u044c\u043d\u043e\u0433\u043e \u0430\u0433\u0435\u043d\u0442\u0441\u0442\u0432\u0430 \u043f\u043e \u0437\u0434\u0440\u0430\u0432\u043e\u043e\u0445\u0440\u0430\u043d\u0435\u043d\u0438\u044e \u0438 \u0441\u043e\u0446. \u0440\u0430\u0437\u0432\u0438\u0442\u0438\u044e; 2010."},{"key":"ref23","unstructured":"\u041c\u0438\u043d\u0443\u0448\u043a\u0438\u043d \u041e.\u041d. \u0423\u0440\u0441\u043e\u0434\u0435\u0437\u043e\u043a\u0441\u0438\u0445\u043e\u043b\u0435\u0432\u0430\u044f \u043a\u0438\u0441\u043b\u043e\u0442\u0430 (\u0423\u0414\u0425\u041a) \u0432 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u043e\u0439 \u043f\u0440\u0430\u043a\u0442\u0438\u043a\u0435. \u041c\u0435\u0434\u0438\u0446\u0438\u043d\u0441\u043a\u0438\u0439 \u0441\u043e\u0432\u0435\u0442. 2010;1-2:12-16."},{"key":"ref24","unstructured":"\u041c\u0430\u0435\u0432 \u0418.\u0412., \u0421\u0430\u043c\u0441\u043e\u043d\u043e\u0432 \u0410.\u0410., \u0421\u0430\u043b\u043e\u0432\u0430 \u041b.\u041c. \u0414\u0438\u0430\u0433\u043d\u043e\u0441\u0442\u0438\u043a\u0430 \u0438 \u043b\u0435\u0447\u0435\u043d\u0438\u0435 \u0437\u0430\u0431\u043e\u043b\u0435\u0432\u0430\u043d\u0438\u0439 \u0436\u0435\u043b\u0447\u0435\u0432\u044b\u0432\u043e\u0434\u044f\u0449\u0438\u0445 \u043f\u0443\u0442\u0435\u0439. \u041c.: \u0413\u041e\u0423 \u0412\u0423\u041d\u041c\u0426 \u041c\u0417 \u0420\u0424; 2003."},{"key":"ref25","unstructured":"\u0411\u0435\u043b\u043e\u0443\u0441\u043e\u0432\u0430 \u0415.\u0410. \u041f\u0440\u0438\u0447\u0438\u043d\u044b, \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u044b \u0438 \u043c\u0435\u0442\u043e\u0434\u044b \u0442\u0435\u0440\u0430\u043f\u0438\u0438 \u0430\u0431\u0434\u043e\u043c\u0438\u043d\u0430\u043b\u044c\u043d\u043e\u0439 \u0431\u043e\u043b\u0438 \u0438 \u043d\u0430\u0440\u0443\u0448\u0435\u043d\u0438\u0439 \u043f\u0438\u0449\u0435\u0432\u0430\u0440\u0435\u043d\u0438\u044f \u043f\u0440\u0438 \u0431\u0438\u043b\u0438\u0430\u0440\u043d\u043e\u0439 \u0434\u0438\u0441\u0444\u0443\u043d\u043a\u0446\u0438\u0438. \u0424\u0430\u0440\u043c\u0430\u0442\u0435\u043a\u0430. 2004;13:45-52."},{"key":"ref26","unstructured":"\u041e\u043a\u043e\u0432\u0438\u0442\u044b\u0439 \u0421.\u0412., \u0428\u0443\u043b\u0435\u043d\u0438\u043d \u0421.\u041d. \u041a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0444\u0430\u0440\u043c\u0430\u043a\u043e\u043b\u043e\u0433\u0438\u044f \u0433\u0435\u043f\u0430\u0442\u043e\u043f\u0440\u043e\u0442\u0435\u043a\u0442\u043e\u0440\u043e\u0432. \u0421\u041f\u0431.: \u0412\u041c\u0435\u0434\u0410 \u0438\u043c. \u0421.\u041c. \u041a\u0438\u0440\u043e\u0432\u0430; 2006."},{"key":"ref27","unstructured":"\u0422\u043a\u0430\u0447\u0435\u043d\u043a\u043e \u0415.\u0418., \u0423\u0441\u043f\u0435\u043d\u0441\u043a\u0438\u0439 \u042e. \u041d\u0435\u0430\u043b\u043a\u043e\u0433\u043e\u043b\u044c\u043d\u0430\u044f \u0436\u0438\u0440\u043e\u0432\u0430\u044f \u0431\u043e\u043b\u0435\u0437\u043d\u044c \u043f\u0435\u0447\u0435\u043d\u0438 \u0438 \u043c\u0435\u0442\u0430\u0431\u043e\u043b\u0438\u0447\u0435\u0441\u043a\u0438\u0439 \u0441\u0438\u043d\u0434\u0440\u043e\u043c: \u0435\u0434\u0438\u043d\u0441\u0442\u0432\u043e \u043f\u0430\u0442\u043e\u0433\u0435\u043d\u0435\u0442\u0438\u0447\u0435\u0441\u043a\u0438\u0445 \u043c\u0435\u0445\u0430\u043d\u0438\u0437\u043c\u043e\u0432 \u0438 \u043f\u043e\u0434\u0445\u043e\u0434\u043e\u0432 \u043a \u043b\u0435\u0447\u0435\u043d\u0438\u044e. \u042d\u043a\u0441\u043f\u0435\u0440\u0438\u043c\u0435\u043d\u0442\u0430\u043b\u044c\u043d\u0430\u044f \u0438 \u043a\u043b\u0438\u043d\u0438\u0447\u0435\u0441\u043a\u0430\u044f \u0433\u0430\u0441\u0442\u0440\u043e\u044d\u043d\u0442\u0435\u0440\u043e\u043b\u043e\u0433\u0438\u044f. 2008;2:92-96."}],"container-title":["Terapevticheskii arkhiv"],"original-title":[],"link":[{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/32086\/pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/viewFile\/32086\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2021,10,13]],"date-time":"2021-10-13T02:38:25Z","timestamp":1634092705000},"score":1,"resource":{"primary":{"URL":"https:\/\/ter-arkhiv.ru\/0040-3660\/article\/view\/32086"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2016,9,15]]},"references-count":27,"journal-issue":{"issue":"9","published-online":{"date-parts":[[2016,9,15]]}},"URL":"https:\/\/doi.org\/10.17116\/terarkh201688978-83","relation":{},"ISSN":["2309-5342","0040-3660"],"issn-type":[{"value":"2309-5342","type":"electronic"},{"value":"0040-3660","type":"print"}],"subject":[],"published":{"date-parts":[[2016,9,15]]}}}